Phorbol 12, 13-dibutyrate-induced, protein kinase C-mediated contraction of rabbit bladder smooth muscle

Phorbol 12, 13-dibutyrate-induced, protein kinase C-mediated contraction of rabbit bladder smooth muscle

Contraction of bladder smooth muscle is predominantly initiated by M3 muscarinic receptor-mediated activation of the Gq/11-phospholipase C β-protein kinase C (PKC) and the G12/13-RhoGEF-Rho kinase (ROCK) pathways. However, these pathways and their downstream effectors are not well understood in bla...

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Bibliographic Details
Main Authors: Tanchun eWang, Derek M Kendig, Danielle M Trappanese, Elaine M Smolock, Robert S Moreland
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-01-01
Series:Frontiers in Pharmacology
Subjects:
bisindolylmaleimide-1
CPI-17
H-1152
MLC phosphatase
MLC phosphorylation
myosin phosphatase target subunit
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00083/full

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