Association of ABO Blood Type with Infection and Severity of COVID-19 in Inpatient and Longitudinal Cohorts
The objectives of this study were to (1) investigate the association between human blood type and COVID-19 in both inpatient and longitudinal populations and (2) identify the association between blood type and severity of COVID-19 via presence of cellular biomarkers of severe infection in hospitaliz...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | COVID |
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| Online Access: | https://www.mdpi.com/2673-8112/3/9/98 |
| _version_ | 1797580689129865216 |
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| author | Tiffany Eatz Alejandro Max Antonio Mantero Erin Williams Charles J. Cash Nathalie Perez Zachary J. Cromar Adiel Hernandez Matthew Cordova Neha Godbole Anh Le Rachel Lin Sherry Luo Anmol Patel Yaa Abu Suresh Pallikkuth Savita Pahwa |
| author_facet | Tiffany Eatz Alejandro Max Antonio Mantero Erin Williams Charles J. Cash Nathalie Perez Zachary J. Cromar Adiel Hernandez Matthew Cordova Neha Godbole Anh Le Rachel Lin Sherry Luo Anmol Patel Yaa Abu Suresh Pallikkuth Savita Pahwa |
| author_sort | Tiffany Eatz |
| collection | DOAJ |
| description | The objectives of this study were to (1) investigate the association between human blood type and COVID-19 in both inpatient and longitudinal populations and (2) identify the association between blood type and severity of COVID-19 via presence of cellular biomarkers of severe infection in hospitalized individuals at our institution in South Florida. This study consisted of (1) a single-center retrospective analysis of 669 out of 2741 COVID-19-positive, screened patients seen from 1 January 2020 until 31 March 2021 at the University of Miami Emergency Department (ED) who tested positive for COVID-19 and had a documented ABO blood type and (2) a longitudinal SARS-CoV-2 immunity study (“CITY”) at the University of Miami Miller School of Medicine, consisting of 185 survey participants. In an inpatient setting, blood type appeared to be associated with COVID-19 severity and mortality. Blood type O sustained less risk of COVID-19 mortality, and blood type O- demonstrated less risk of developing COVID-19 pneumonia. Inpatients with O- blood type exhibited less biomarkers of severe infection than did other blood types. In a longitudinal setting, there was no association found between blood type and SARS-CoV-2 infection. |
| first_indexed | 2024-03-10T22:54:30Z |
| format | Article |
| id | doaj.art-a6db9a682ff94f70bbf9c111fb9a9d91 |
| institution | Directory Open Access Journal |
| issn | 2673-8112 |
| language | English |
| last_indexed | 2024-03-10T22:54:30Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | COVID |
| spelling | doaj.art-a6db9a682ff94f70bbf9c111fb9a9d912023-11-19T10:08:24ZengMDPI AGCOVID2673-81122023-09-01391429143910.3390/covid3090098Association of ABO Blood Type with Infection and Severity of COVID-19 in Inpatient and Longitudinal CohortsTiffany Eatz0Alejandro Max Antonio Mantero1Erin Williams2Charles J. Cash3Nathalie Perez4Zachary J. Cromar5Adiel Hernandez6Matthew Cordova7Neha Godbole8Anh Le9Rachel Lin10Sherry Luo11Anmol Patel12Yaa Abu13Suresh Pallikkuth14Savita Pahwa15Department of Microbiology & Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Microbiology & Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Microbiology & Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Microbiology & Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Microbiology & Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Microbiology & Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Microbiology & Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Microbiology & Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Microbiology & Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Microbiology & Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Microbiology & Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Microbiology & Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Microbiology & Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Microbiology & Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Microbiology & Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USAThe objectives of this study were to (1) investigate the association between human blood type and COVID-19 in both inpatient and longitudinal populations and (2) identify the association between blood type and severity of COVID-19 via presence of cellular biomarkers of severe infection in hospitalized individuals at our institution in South Florida. This study consisted of (1) a single-center retrospective analysis of 669 out of 2741 COVID-19-positive, screened patients seen from 1 January 2020 until 31 March 2021 at the University of Miami Emergency Department (ED) who tested positive for COVID-19 and had a documented ABO blood type and (2) a longitudinal SARS-CoV-2 immunity study (“CITY”) at the University of Miami Miller School of Medicine, consisting of 185 survey participants. In an inpatient setting, blood type appeared to be associated with COVID-19 severity and mortality. Blood type O sustained less risk of COVID-19 mortality, and blood type O- demonstrated less risk of developing COVID-19 pneumonia. Inpatients with O- blood type exhibited less biomarkers of severe infection than did other blood types. In a longitudinal setting, there was no association found between blood type and SARS-CoV-2 infection.https://www.mdpi.com/2673-8112/3/9/98coronaviruspneumoniarespiratoryvirologymortalityimmunology |
| spellingShingle | Tiffany Eatz Alejandro Max Antonio Mantero Erin Williams Charles J. Cash Nathalie Perez Zachary J. Cromar Adiel Hernandez Matthew Cordova Neha Godbole Anh Le Rachel Lin Sherry Luo Anmol Patel Yaa Abu Suresh Pallikkuth Savita Pahwa Association of ABO Blood Type with Infection and Severity of COVID-19 in Inpatient and Longitudinal Cohorts COVID coronavirus pneumonia respiratory virology mortality immunology |
| title | Association of ABO Blood Type with Infection and Severity of COVID-19 in Inpatient and Longitudinal Cohorts |
| title_full | Association of ABO Blood Type with Infection and Severity of COVID-19 in Inpatient and Longitudinal Cohorts |
| title_fullStr | Association of ABO Blood Type with Infection and Severity of COVID-19 in Inpatient and Longitudinal Cohorts |
| title_full_unstemmed | Association of ABO Blood Type with Infection and Severity of COVID-19 in Inpatient and Longitudinal Cohorts |
| title_short | Association of ABO Blood Type with Infection and Severity of COVID-19 in Inpatient and Longitudinal Cohorts |
| title_sort | association of abo blood type with infection and severity of covid 19 in inpatient and longitudinal cohorts |
| topic | coronavirus pneumonia respiratory virology mortality immunology |
| url | https://www.mdpi.com/2673-8112/3/9/98 |
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