The Glioblastoma CircularRNAome
Glioblastoma remains one of the most aggressive cancers of the brain, warranting new methods for early diagnosis and more efficient treatment options. Circular RNAs (circRNAs) are rather new entities with increased stability compared to their linear counterparts that interact with proteins and act a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/19/14545 |
| _version_ | 1797575836050653184 |
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| author | Alexandru Tirpe Cristian Streianu Stefana Maria Tirpe Anja Kocijancic Radu Pirlog Bianca Pirlog Constantin Busuioc Ovidiu-Laurean Pop Ioana Berindan-Neagoe |
| author_facet | Alexandru Tirpe Cristian Streianu Stefana Maria Tirpe Anja Kocijancic Radu Pirlog Bianca Pirlog Constantin Busuioc Ovidiu-Laurean Pop Ioana Berindan-Neagoe |
| author_sort | Alexandru Tirpe |
| collection | DOAJ |
| description | Glioblastoma remains one of the most aggressive cancers of the brain, warranting new methods for early diagnosis and more efficient treatment options. Circular RNAs (circRNAs) are rather new entities with increased stability compared to their linear counterparts that interact with proteins and act as microRNA sponges, among other functions. Herein, we provide a critical overview of the recently described glioblastoma-related circRNAs in the literature, focusing on their roles on glioblastoma cancer cell proliferation, survival, migration, invasion and metastasis, metabolic reprogramming, and therapeutic resistance. The main roles of circRNAs in regulating cancer processes are due to their regulatory roles in essential oncogenic pathways, including MAPK, PI3K/AKT/mTOR, and Wnt, which are influenced by various circRNAs. The present work pictures the wide implication of circRNAs in glioblastoma, thus highlighting their potential as future biomarkers and therapeutic targets/agents. |
| first_indexed | 2024-03-10T21:43:54Z |
| format | Article |
| id | doaj.art-a6de2faebee140fc9bdd3d3d7590af4a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T21:43:54Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a6de2faebee140fc9bdd3d3d7590af4a2023-11-19T14:28:11ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124191454510.3390/ijms241914545The Glioblastoma CircularRNAomeAlexandru Tirpe0Cristian Streianu1Stefana Maria Tirpe2Anja Kocijancic3Radu Pirlog4Bianca Pirlog5Constantin Busuioc6Ovidiu-Laurean Pop7Ioana Berindan-Neagoe8Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 23 Marinescu Street, 400337 Cluj-Napoca, RomaniaThe Oncology Institute “Prof. Dr. Ion Chiricuta”, 400015 Cluj-Napoca, RomaniaDepartment of Neurology, Ortenau-Klinikum Lahr, Klostenstrasse 19, 7933 Lahr, GermanyDepartment of Microbiology, Oslo University Hospital, N-0424 Oslo, NorwayResearch Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 23 Marinescu Street, 400337 Cluj-Napoca, RomaniaDepartment of Neurology, County Emergency Hospital, 400012 Cluj-Napoca, RomaniaDepartment of Pathology, National Institute of Infectious Disease, 021105 Bucharest, RomaniaDepartment of Morphological Sciences, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, RomaniaResearch Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 23 Marinescu Street, 400337 Cluj-Napoca, RomaniaGlioblastoma remains one of the most aggressive cancers of the brain, warranting new methods for early diagnosis and more efficient treatment options. Circular RNAs (circRNAs) are rather new entities with increased stability compared to their linear counterparts that interact with proteins and act as microRNA sponges, among other functions. Herein, we provide a critical overview of the recently described glioblastoma-related circRNAs in the literature, focusing on their roles on glioblastoma cancer cell proliferation, survival, migration, invasion and metastasis, metabolic reprogramming, and therapeutic resistance. The main roles of circRNAs in regulating cancer processes are due to their regulatory roles in essential oncogenic pathways, including MAPK, PI3K/AKT/mTOR, and Wnt, which are influenced by various circRNAs. The present work pictures the wide implication of circRNAs in glioblastoma, thus highlighting their potential as future biomarkers and therapeutic targets/agents.https://www.mdpi.com/1422-0067/24/19/14545circRNAglioblastomancRNA |
| spellingShingle | Alexandru Tirpe Cristian Streianu Stefana Maria Tirpe Anja Kocijancic Radu Pirlog Bianca Pirlog Constantin Busuioc Ovidiu-Laurean Pop Ioana Berindan-Neagoe The Glioblastoma CircularRNAome International Journal of Molecular Sciences circRNA glioblastoma ncRNA |
| title | The Glioblastoma CircularRNAome |
| title_full | The Glioblastoma CircularRNAome |
| title_fullStr | The Glioblastoma CircularRNAome |
| title_full_unstemmed | The Glioblastoma CircularRNAome |
| title_short | The Glioblastoma CircularRNAome |
| title_sort | glioblastoma circularrnaome |
| topic | circRNA glioblastoma ncRNA |
| url | https://www.mdpi.com/1422-0067/24/19/14545 |
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