Influence of the Substituents on the Opening of Silylepoxy Alcohols: 5-<i>exo</i>-Cyclization towards Tetrahydrofurans vs. Unexpected Side Reaction Leading to Tetrahydropyrans

Influence of the Substituents on the Opening of Silylepoxy Alcohols: 5-<i>exo</i>-Cyclization towards Tetrahydrofurans vs. Unexpected Side Reaction Leading to Tetrahydropyrans

The regioselective ring opening of epoxy alcohols is an effective method for the synthesis of different types of oxacycles. The 5-<i>exo</i> opening being preferred vs. the 6-<i>endo</i> mode, according to Baldwin rules, the use of silyl-substituted oxiranes has been reported...

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Bibliographic Details
Main Authors: Carlos Díez-Poza, Asunción Barbero
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Molecules
Subjects:
tetrahydropyrans
tetrahydrofurans
cyclization
epoxysilyl alcohols
side reaction
tandem process
Online Access:https://www.mdpi.com/1420-3049/26/23/7386

Internet

https://www.mdpi.com/1420-3049/26/23/7386

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