The Genetic and Clinical Outcomes in Fetuses With Isolated Fetal Growth Restriction: A Chinese Single-Center Retrospective Study
Objective: To evaluate the utility of a chromosomal microarray (CMA) in fetuses with isolated fetal growth restriction (FGR) and explore risk factors for the prediction of chromosomal aberration and perinatal adverse outcomes.Method: This study included 271 fetuses of estimated fetal weight less tha...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-04-01
|
| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.856522/full |
| _version_ | 1818011087611625472 |
|---|---|
| author | Hang Zhou Ken Cheng Yingsi Li Fang Fu Ru Li Yongling Zhang Xin Yang Xiangyi Jing Fucheng Li Jin Han Min Pan Li Zhen Dongzhi Li Can Liao |
| author_facet | Hang Zhou Ken Cheng Yingsi Li Fang Fu Ru Li Yongling Zhang Xin Yang Xiangyi Jing Fucheng Li Jin Han Min Pan Li Zhen Dongzhi Li Can Liao |
| author_sort | Hang Zhou |
| collection | DOAJ |
| description | Objective: To evaluate the utility of a chromosomal microarray (CMA) in fetuses with isolated fetal growth restriction (FGR) and explore risk factors for the prediction of chromosomal aberration and perinatal adverse outcomes.Method: This study included 271 fetuses of estimated fetal weight less than the 3rd percentile without other structural malformation. Early-onset and late-onset FGR were defined as gestational weeks less than 32 weeks and more than 32 weeks respectively. These patients underwent quantitative fluorescent polymerase chain reaction (QF-PCR) and CMA as the first-line genetic detection strategy. Chromosomal anomalies were compared after stratified analysis by the early-onset and the late-onset FGR, including the absence or presence of ultrasound soft markers, abnormal amniotic fluid, abnormal umbilical Doppler, and gestational disorders. The follow-up time was within 1 year after birth. Logistic regression was used to seek risk predictors of chromosomal aberration and perinatal adverse outcomes for isolated FGR.Results: The CMA identified clinically significant variants in 18/271 (6.6%) fetuses, and variants of unknown significance (VOUS) in 15/271 (5.5%) fetuses. Stratified analysis showed that there was a higher incidence of clinically significant variants in fetuses with the early-onset FGR compared with late-onset FGR (8.7%, 17/195 vs. 1.3%, 1/76, p < 0.05). Regression analysis showed that early gestational age (GA) at diagnosis of FGR was the major risk factor for chromosomal aberration (OR = 0.846). By variable regression analysis, early GA at diagnosis and decreased estimated fetal weight (EFW) percentile of suspicion of FGR, asymmetrical FGR, abnormal amniotic fluid, and severe preeclampsia could all increase the risk of adverse outcomes of isolated FGR including intra-uterine fetal death (IUFD), termination of pregnancy (TOP), and preterm birth in pregnancies with FGR.Conclusion: This study emphasized the value of microarrays for unbalanced genomic variants in fetuses with isolated FGR, especially since the gestational age of nullipara was less than 32 weeks. Perinatal adverse outcomes of isolated FGR were influenced by multiple factors including GA and estimated fetal weight (EFW) percentile of suspicion of FGR, asymmetrical FGR, abnormal amniotic fluid, and severe preeclampsia. |
| first_indexed | 2024-04-14T06:02:54Z |
| format | Article |
| id | doaj.art-a6df5a07d67b4701acb5718f1dad9633 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-14T06:02:54Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-a6df5a07d67b4701acb5718f1dad96332022-12-22T02:08:41ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-04-011310.3389/fgene.2022.856522856522The Genetic and Clinical Outcomes in Fetuses With Isolated Fetal Growth Restriction: A Chinese Single-Center Retrospective StudyHang Zhou0Ken Cheng1Yingsi Li2Fang Fu3Ru Li4Yongling Zhang5Xin Yang6Xiangyi Jing7Fucheng Li8Jin Han9Min Pan10Li Zhen11Dongzhi Li12Can Liao13Prenatal Diagnostic Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaSchool of Medicine, South China University of Technology, Guangzhou, ChinaPrenatal Diagnostic Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaPrenatal Diagnostic Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaPrenatal Diagnostic Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaPrenatal Diagnostic Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaPrenatal Diagnostic Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaPrenatal Diagnostic Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaPrenatal Diagnostic Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaPrenatal Diagnostic Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaPrenatal Diagnostic Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaPrenatal Diagnostic Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaPrenatal Diagnostic Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaPrenatal Diagnostic Center, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, ChinaObjective: To evaluate the utility of a chromosomal microarray (CMA) in fetuses with isolated fetal growth restriction (FGR) and explore risk factors for the prediction of chromosomal aberration and perinatal adverse outcomes.Method: This study included 271 fetuses of estimated fetal weight less than the 3rd percentile without other structural malformation. Early-onset and late-onset FGR were defined as gestational weeks less than 32 weeks and more than 32 weeks respectively. These patients underwent quantitative fluorescent polymerase chain reaction (QF-PCR) and CMA as the first-line genetic detection strategy. Chromosomal anomalies were compared after stratified analysis by the early-onset and the late-onset FGR, including the absence or presence of ultrasound soft markers, abnormal amniotic fluid, abnormal umbilical Doppler, and gestational disorders. The follow-up time was within 1 year after birth. Logistic regression was used to seek risk predictors of chromosomal aberration and perinatal adverse outcomes for isolated FGR.Results: The CMA identified clinically significant variants in 18/271 (6.6%) fetuses, and variants of unknown significance (VOUS) in 15/271 (5.5%) fetuses. Stratified analysis showed that there was a higher incidence of clinically significant variants in fetuses with the early-onset FGR compared with late-onset FGR (8.7%, 17/195 vs. 1.3%, 1/76, p < 0.05). Regression analysis showed that early gestational age (GA) at diagnosis of FGR was the major risk factor for chromosomal aberration (OR = 0.846). By variable regression analysis, early GA at diagnosis and decreased estimated fetal weight (EFW) percentile of suspicion of FGR, asymmetrical FGR, abnormal amniotic fluid, and severe preeclampsia could all increase the risk of adverse outcomes of isolated FGR including intra-uterine fetal death (IUFD), termination of pregnancy (TOP), and preterm birth in pregnancies with FGR.Conclusion: This study emphasized the value of microarrays for unbalanced genomic variants in fetuses with isolated FGR, especially since the gestational age of nullipara was less than 32 weeks. Perinatal adverse outcomes of isolated FGR were influenced by multiple factors including GA and estimated fetal weight (EFW) percentile of suspicion of FGR, asymmetrical FGR, abnormal amniotic fluid, and severe preeclampsia.https://www.frontiersin.org/articles/10.3389/fgene.2022.856522/fullisolated fetal growth restrictionchromosomal microarraycopy number variantsprenatal diagnosisperinatal outcome |
| spellingShingle | Hang Zhou Ken Cheng Yingsi Li Fang Fu Ru Li Yongling Zhang Xin Yang Xiangyi Jing Fucheng Li Jin Han Min Pan Li Zhen Dongzhi Li Can Liao The Genetic and Clinical Outcomes in Fetuses With Isolated Fetal Growth Restriction: A Chinese Single-Center Retrospective Study Frontiers in Genetics isolated fetal growth restriction chromosomal microarray copy number variants prenatal diagnosis perinatal outcome |
| title | The Genetic and Clinical Outcomes in Fetuses With Isolated Fetal Growth Restriction: A Chinese Single-Center Retrospective Study |
| title_full | The Genetic and Clinical Outcomes in Fetuses With Isolated Fetal Growth Restriction: A Chinese Single-Center Retrospective Study |
| title_fullStr | The Genetic and Clinical Outcomes in Fetuses With Isolated Fetal Growth Restriction: A Chinese Single-Center Retrospective Study |
| title_full_unstemmed | The Genetic and Clinical Outcomes in Fetuses With Isolated Fetal Growth Restriction: A Chinese Single-Center Retrospective Study |
| title_short | The Genetic and Clinical Outcomes in Fetuses With Isolated Fetal Growth Restriction: A Chinese Single-Center Retrospective Study |
| title_sort | genetic and clinical outcomes in fetuses with isolated fetal growth restriction a chinese single center retrospective study |
| topic | isolated fetal growth restriction chromosomal microarray copy number variants prenatal diagnosis perinatal outcome |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.856522/full |
| work_keys_str_mv | AT hangzhou thegeneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy AT kencheng thegeneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy AT yingsili thegeneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy AT fangfu thegeneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy AT ruli thegeneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy AT yonglingzhang thegeneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy AT xinyang thegeneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy AT xiangyijing thegeneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy AT fuchengli thegeneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy AT jinhan thegeneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy AT minpan thegeneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy AT lizhen thegeneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy AT dongzhili thegeneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy AT canliao thegeneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy AT hangzhou geneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy AT kencheng geneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy AT yingsili geneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy AT fangfu geneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy AT ruli geneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy AT yonglingzhang geneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy AT xinyang geneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy AT xiangyijing geneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy AT fuchengli geneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy AT jinhan geneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy AT minpan geneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy AT lizhen geneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy AT dongzhili geneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy AT canliao geneticandclinicaloutcomesinfetuseswithisolatedfetalgrowthrestrictionachinesesinglecenterretrospectivestudy |