Novel laparoscopic renal denervation immediately reduces atrial fibrillation inducibility: a swine model study
Abstract Catheter-based approaches may have inherent limitations in achieving effective renal denervation (RDN) and treatment of atrial fibrillation (AF). This study aimed to investigate the acute effects of novel laparoscopic RDN on modulating AF inducibility using a swine model. Four and five swin...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-47077-w |
| _version_ | 1827764450359246848 |
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| author | Soonil Kwon Eue-Keun Choi Hyo-Jeong Ahn So-Ryoung Lee Seil Oh Si Hyun Kim Minh-Tung Do Jang Hee Han Chang Wook Jeong |
| author_facet | Soonil Kwon Eue-Keun Choi Hyo-Jeong Ahn So-Ryoung Lee Seil Oh Si Hyun Kim Minh-Tung Do Jang Hee Han Chang Wook Jeong |
| author_sort | Soonil Kwon |
| collection | DOAJ |
| description | Abstract Catheter-based approaches may have inherent limitations in achieving effective renal denervation (RDN) and treatment of atrial fibrillation (AF). This study aimed to investigate the acute effects of novel laparoscopic RDN on modulating AF inducibility using a swine model. Four and five swine were randomly allocated to the sham and RDN groups, respectively. Each swine underwent measurement of the atrial effective refractory period (AERP) and AF induction tests using burst atrial pacing before and immediately after sham or RDN procedures with and without vagal nerve stimulation (VNS). A laparoscopic RDN procedure circumferentially ablated the renal nerves round the renal arteries using radiofrequency energy. There was no significant difference in the baseline AERP between the two groups (p > 0.05). Under VNS, AERP was significantly increased by 20 ms after laparoscopic RDN (95% CI = 0–30, p = 0.004). Compared to the sham group, the RDN group showed significantly reduced AF inducibility [OR (95% CI) = 0.32 (0.13–0.76) and 0.24 (0.11–0.57) with and without VNS, respectively]. After laparoscopic RDN, the duration of inducible AF episodes was significantly shortened from 28 (10–77) s to 7 (3–11) s (p < 0.001). The novel laparoscopic RDN can immediately reduce AF inducibility in a swine model. |
| first_indexed | 2024-03-11T11:04:35Z |
| format | Article |
| id | doaj.art-a6dfa9ab332849578784f51145a70043 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-11T11:04:35Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a6dfa9ab332849578784f51145a700432023-11-12T12:16:55ZengNature PortfolioScientific Reports2045-23222023-11-011311810.1038/s41598-023-47077-wNovel laparoscopic renal denervation immediately reduces atrial fibrillation inducibility: a swine model studySoonil Kwon0Eue-Keun Choi1Hyo-Jeong Ahn2So-Ryoung Lee3Seil Oh4Si Hyun Kim5Minh-Tung Do6Jang Hee Han7Chang Wook Jeong8Division of Cardiology, Department of Internal Medicine, Seoul National University HospitalDivision of Cardiology, Department of Internal Medicine, Seoul National University HospitalDivision of Cardiology, Department of Internal Medicine, Seoul National University HospitalDivision of Cardiology, Department of Internal Medicine, Seoul National University HospitalDivision of Cardiology, Department of Internal Medicine, Seoul National University HospitalDepartment of Urology, Seoul National University HospitalDepartment of Urology, Seoul National University HospitalDepartment of Urology, Seoul National University HospitalDepartment of Urology, Seoul National University HospitalAbstract Catheter-based approaches may have inherent limitations in achieving effective renal denervation (RDN) and treatment of atrial fibrillation (AF). This study aimed to investigate the acute effects of novel laparoscopic RDN on modulating AF inducibility using a swine model. Four and five swine were randomly allocated to the sham and RDN groups, respectively. Each swine underwent measurement of the atrial effective refractory period (AERP) and AF induction tests using burst atrial pacing before and immediately after sham or RDN procedures with and without vagal nerve stimulation (VNS). A laparoscopic RDN procedure circumferentially ablated the renal nerves round the renal arteries using radiofrequency energy. There was no significant difference in the baseline AERP between the two groups (p > 0.05). Under VNS, AERP was significantly increased by 20 ms after laparoscopic RDN (95% CI = 0–30, p = 0.004). Compared to the sham group, the RDN group showed significantly reduced AF inducibility [OR (95% CI) = 0.32 (0.13–0.76) and 0.24 (0.11–0.57) with and without VNS, respectively]. After laparoscopic RDN, the duration of inducible AF episodes was significantly shortened from 28 (10–77) s to 7 (3–11) s (p < 0.001). The novel laparoscopic RDN can immediately reduce AF inducibility in a swine model.https://doi.org/10.1038/s41598-023-47077-w |
| spellingShingle | Soonil Kwon Eue-Keun Choi Hyo-Jeong Ahn So-Ryoung Lee Seil Oh Si Hyun Kim Minh-Tung Do Jang Hee Han Chang Wook Jeong Novel laparoscopic renal denervation immediately reduces atrial fibrillation inducibility: a swine model study Scientific Reports |
| title | Novel laparoscopic renal denervation immediately reduces atrial fibrillation inducibility: a swine model study |
| title_full | Novel laparoscopic renal denervation immediately reduces atrial fibrillation inducibility: a swine model study |
| title_fullStr | Novel laparoscopic renal denervation immediately reduces atrial fibrillation inducibility: a swine model study |
| title_full_unstemmed | Novel laparoscopic renal denervation immediately reduces atrial fibrillation inducibility: a swine model study |
| title_short | Novel laparoscopic renal denervation immediately reduces atrial fibrillation inducibility: a swine model study |
| title_sort | novel laparoscopic renal denervation immediately reduces atrial fibrillation inducibility a swine model study |
| url | https://doi.org/10.1038/s41598-023-47077-w |
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