Identification of critical genes associated with radiotherapy resistance in cervical cancer by bioinformatics

Identification of critical genes associated with radiotherapy resistance in cervical cancer by bioinformatics

BackgroundCervical cancer (CC) is one of the common malignant tumors in women, Currently, 30% of patients with intermediate to advanced squamous cervical cancer are still uncontrolled or recurrent after standard radical simultaneous radiotherapy; therefore, the search for critical genes affecting th...

Full description

Bibliographic Details
Main Authors:	Zhenhua Zhang, Kechao Xiang, Longjing Tan, Xiuju Du, Huailin He, Dan Li, Li Li, Qinglian Wen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-07-01
Series:	Frontiers in Oncology
Subjects:	bioinformatics cervical squamous cell carcinoma radiotherapy DEGs prognosis
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2022.967386/full

Similar Items

Bioinformatics Analysis Highlights Five Differentially Expressed Genes as Prognostic Biomarkers of Cervical Cancer and Novel Option for Anticancer Treatment
by: Hongtu Cui, et al.
Published: (2022-06-01)

Identification of differentially expressed genes in cervical carcinoma after radiotherapy
by: BAI Jing, LIU Na, DING Li, LEI Li, NI Rui, YAN Shao-chun, SHAO Guo
Published: (2022-02-01)

Elevated pretreatment squamous cell Carcinoma Antigen indicates unfavorable treatment outcomes in cervical cancer patients receiving definitive radiotherapy
by: Dingchao Liu, et al.
Published: (2023-09-01)

Radiotherapy for postoperative vaginal recurrences of cervical squamous cell carcinoma: analysis of dosing and prognosis
by: Ziye Zheng, et al.
Published: (2023-12-01)

Identification of Critical Signature in Post‐Traumatic Stress Disorder Using Bioinformatics Analysis and in Vitro Analyses
by: Lifen Liu, et al.
Published: (2025-01-01)

Mapping of Regional Failures After Definitive Radiotherapy in Patients with Locally Advanced Cervical Esophageal Carcinoma
by: Zhao D, et al.
Published: (2020-07-01)

Outcomes and prognostic factors for patients with cervical esophageal cancer undergoing definitive radiotherapy or chemoradiotherapy
by: Xin-xin Du, et al.
Published: (2019-05-01)

Successful inguinal interstitial brachytherapy in metastatic cervical carcinoma: a case report
by: Yi Qin, et al.
Published: (2024-01-01)

Deep-learning-based radiomics of intratumoral and peritumoral MRI images to predict the pathological features of adjuvant radiotherapy in early-stage cervical squamous cell carcinoma
by: Xue-Fang Zhang, et al.
Published: (2024-03-01)

Outcome and prognostic factors in cervical cancer patients treated with surgery and concurrent chemoradiotherapy: a retrospective study
by: Yan-Mei Liu, et al.
Published: (2018-01-01)

Elevated POSTN expression predicts poor prognosis and is associated with radioresistance in cervical cancer patients treated with radical radiotherapy
by: Cui-qin Huang, et al.
Published: (2025-02-01)

Construction and validation of a metabolic-related genes prognostic model for oral squamous cell carcinoma based on bioinformatics
by: Jingfei Zhang, et al.
Published: (2022-12-01)

Aberrant SNHG expression predicts poor prognosis in esophageal cancer using meta-analysis and bioinformatics analysis
by: Ke Shi, et al.
Published: (2025-02-01)

Clinical outcome of adjuvant radiotherapy for squamous cell carcinoma of the breast; a multicenter retrospective cohort study
by: Mami Ogita, et al.
Published: (2020-08-01)

Construction and evaluation of a prognostic model for cervical cancer based on dynamic hematological and clinical features
by: Huangrong Ma, et al.
Published: (2025-02-01)

A prognostic model using FIGO 2018 staging and MRI-derived tumor volume to predict long-term outcomes in patients with uterine cervical squamous cell carcinoma who received definitive radiotherapy
by: Lele Zang, et al.
Published: (2023-07-01)

FOLR1 was up-regulated in cervical squamous cell carcinoma and correlated with the patients’ progression free survival
by: Xie Ling, et al.
Published: (2020-06-01)

Identification of an individualized therapy prognostic signature for head and neck squamous cell carcinoma
by: Cheng Lin, et al.
Published: (2023-04-01)

Radiotherapy and chemoradiotherapy for postoperative recurrence in patients with esophageal squamous cell carcinoma
by: Qing Liu, et al.
Published: (2024-08-01)

Construction of A Nomogram Prognostic Model Based on Pretreatment Inflammatory Indicator for Esophageal Squamous Cell Carcinoma Patients Treated with Radical Radiotherapy
by: Shenbo FU, et al.
Published: (2025-02-01)

Review of possible mechanisms of radiotherapy resistance in cervical cancer
by: Hanqun Zhang, et al.
Published: (2023-08-01)

Stratified Prognostic Comparison Between Stage IIB-IVA Cervical Adenocarcinoma and Squamous Cell Carcinoma: A SEER Database-Based Study
by: Guo H, et al.
Published: (2024-04-01)

Disparities in Survival Outcomes Between Locally Advanced Cervical Squamous Cell Carcinoma and Adenocarcinoma Treated with Chemoradiotherapy
by: Hong SS, et al.
Published: (2024-03-01)

Efficacy of treatment patterns based on concurrent chemoradiotherapy in patients with stage IIB cervical squamous cell carcinoma
by: Xin-Bin Pan, et al.
Published: (2024-01-01)

Low Lymphocyte Count Is Associated With Radiotherapy Parameters and Affects the Outcomes of Esophageal Squamous Cell Carcinoma Patients
by: Xin Wang, et al.
Published: (2020-06-01)

Key Considerations for Ovarian Preservation during Radiotherapy for Cervical Carcinoma
by: Xiaolong Cheng, et al.
Published: (2025-02-01)

Bioinformatics evaluation of the circRNA–miRNA–mRNA axis in cervical squamous cell carcinoma
by: Murat KAYA
Published: (2024-08-01)

Predicting radiotherapy efficacy and prognosis in tongue squamous cell carcinoma through an in-depth analysis of a radiosensitivity gene signature
by: Jinzhi Lai, et al.
Published: (2024-08-01)

The Number of Positive Pelvic Lymph Nodes and Multiple Groups of Pelvic Lymph Node Metastasis Influence Prognosis in Stage IA-IIB Cervical Squamous Cell Carcinoma
by: Yu Liu, et al.
Published: (2015-01-01)

Modern Techniques for Cervical Cancer Radiotherapy
by: P. A. Lushnikova, et al.
Published: (2021-04-01)

Comparison of characteristics of cervical cancer screening history between cervical adenocarcinoma and cervical squamous cell carcinoma
by: Ye Minjuan, Li Jing, Chen Zifei, He Junxian, Chen Lifa, Zhang Yu
Published: (2024-04-01)

Integrative Multi−Omics Analysis Reveals Candidate Biomarkers for Oral Squamous Cell Carcinoma
by: Zhengqing Wan, et al.
Published: (2022-01-01)

Identification of early onset pre-eclampsia related key genes via bioinformatic analysis
by: Zhengrui Huang, et al.
Published: (2022-01-01)

Identification of Key Genes Related to the Prognosis of Esophageal Squamous Cell Carcinoma Based on Chip Re-Annotation
by: Meiqi Wang, et al.
Published: (2021-04-01)

RETRACTED ARTICLE: Screening and identification of susceptibility genes for cervical cancer via bioinformatics analysis and the construction of an mitophagy-related genes diagnostic model
by: Zhang Zhang, et al.
Published: (2024-09-01)

Prognostic value of SOX9 in cervical cancer: Bioinformatics and experimental approaches
by: Huan Chen, et al.
Published: (2022-08-01)

Exploration of the underlying comorbidity mechanism in psoriasis and periodontitis: a bioinformatics analysis
by: Hao Lei, et al.
Published: (2023-02-01)

Application and Update of Radiotherapy in the Treatment of Cervical Cancer
by: Yuxuan LIN, Weimin KONG, Yuanjing WANG, Fengshuang LI
Published: (2022-06-01)

Abdominal Radical Hysterectomy as an Alternative Treatment Option for Patients with Cervical Cancer without Access to Radiotherapy Facilities
by: Yanna Ye, et al.
Published: (2023-10-01)

Survival Comparison Between Squamous Cell Carcinoma and Adenocarcinoma for Radiotherapy-Treated Patients with Stage IIB-IVA Cervical Cancer
by: Fangjie Chen, et al.
Published: (2022-07-01)