Lipidomics analysis facilitate insight into the molecular mechanisms of urate nephropathy in a gout model induced by combination of MSU crystals injection and high-fat diet feeding

Lipidomics analysis facilitate insight into the molecular mechanisms of urate nephropathy in a gout model induced by combination of MSU crystals injection and high-fat diet feeding

Renal injury is one of the most common clinical manifestations of patients with hyperuricaemia/gout. The precise pathophysiological mechanism(s) for the renal injury is still unknown. Furthermore, it is also unclear whether the clinical therapies (e.g., colchicine and febuxostat) could prevent its p...

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Bibliographic Details
Main Authors: Guifeng Hao, Xiaofen Xu, Jingyi Song, Jida Zhang, Kejun Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
gout
hyperuricaemia
lipidomics
inflammation
cardiolipin
4-hydroxyalkenal
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1190683/full

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