EpCAM-Targeted 3WJ RNA Nanoparticle Harboring Delta-5-Desaturase siRNA Inhibited Lung Tumor Formation via DGLA Peroxidation

EpCAM-Targeted 3WJ RNA Nanoparticle Harboring Delta-5-Desaturase siRNA Inhibited Lung Tumor Formation via DGLA Peroxidation

Knocking down delta-5-desaturase (D5D) expression by D5D small interfering RNA (siRNA) has been reported that could redirect the cyclooxygenase-2 (COX-2)-catalyzed dihomo-γ-linolenic acid (DGLA) peroxidation from producing prostaglandin E2 to 8-hydroxyoctanoic acid (8-HOA), resulting in the inhibiti...

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Bibliographic Details
Main Authors: Lizhi Pang, Harshit Shah, Hongzhi Wang, Dan Shu, Steven Y. Qian, Venkatachalem Sathish
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
3WJ RNA nanoparticle
DGLA peroxidation
HDAC
non-small cell lung cancer
YAP1/TAZ pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120302535

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