Pan-cancer analysis revealed prognosis value and immunological relevance of RAMPs
Whether receptor activity-modifying proteins (RAMPs) play a key role in human cancer prognosis and immunity remains unknown. We used data from the public databases, The Cancer Genome Atlas, Therapeutically Applicable Research to Generate Effective Treatments, and the Genotype-Tissue Expression proje...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024008806 |
| _version_ | 1797304570582401024 |
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| author | Sha Yang Renzheng Huan Mei Deng Tao Luo Shuo Peng Yunbiao Xiong Guoqiang Han Jian Liu Jiqin Zhang Ying Tan |
| author_facet | Sha Yang Renzheng Huan Mei Deng Tao Luo Shuo Peng Yunbiao Xiong Guoqiang Han Jian Liu Jiqin Zhang Ying Tan |
| author_sort | Sha Yang |
| collection | DOAJ |
| description | Whether receptor activity-modifying proteins (RAMPs) play a key role in human cancer prognosis and immunity remains unknown. We used data from the public databases, The Cancer Genome Atlas, Therapeutically Applicable Research to Generate Effective Treatments, and the Genotype-Tissue Expression project. We utilized bioinformatics methods, R software, and a variety of online databases to analyze RAMPs. In general, RAMPs were significantly and differentially expressed in multiple tumors, and RAMP expression was closely associated with prognosis, immune checkpoints, RNA-editing genes, tumor mutational burden, microsatellite instability, ploidy, and stemness indices. In addition, the expression of RAMPs is strongly correlated with tumor-infiltrating lymphocytes in human cancers. Moreover, the RAMP co-expression network is largely involved in many immune-related biological processes. Quantitative reverse transcription polymerase chain reaction and Western blot proved that RAMP3 was highly expressed in glioma, and RAMP3 promoted tumor proliferation and migration. RAMPs exhibit potential as prognostic and immune-related biomarkers in human cancers. Moreover, RAMPs can be potentially developed as therapeutic targets or used to enhance the efficacy of immunotherapy. |
| first_indexed | 2024-03-08T00:12:21Z |
| format | Article |
| id | doaj.art-a6e4cdc7b78d4e66849094e41eb53c1b |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T00:12:21Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-a6e4cdc7b78d4e66849094e41eb53c1b2024-02-17T06:38:51ZengElsevierHeliyon2405-84402024-02-01103e24849Pan-cancer analysis revealed prognosis value and immunological relevance of RAMPsSha Yang0Renzheng Huan1Mei Deng2Tao Luo3Shuo Peng4Yunbiao Xiong5Guoqiang Han6Jian Liu7Jiqin Zhang8Ying Tan9Guizhou University Medical College, Guiyang, 550025, Guizhou Province, ChinaDepartment of Neurosurgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Neurosurgery, Guizhou Provincial People's Hospital, Guiyang, ChinaDepartment of Neurosurgery, Guizhou Provincial People's Hospital, Guiyang, ChinaDepartment of Neurosurgery, Guizhou Provincial People's Hospital, Guiyang, ChinaDepartment of Neurosurgery, Guizhou Provincial People's Hospital, Guiyang, ChinaDepartment of Neurosurgery, Guizhou Provincial People's Hospital, Guiyang, ChinaGuizhou University Medical College, Guiyang, 550025, Guizhou Province, China; Department of Neurosurgery, Guizhou Provincial People's Hospital, Guiyang, China; Corresponding author. Guizhou University Medical College, Guiyang, 550025, Guizhou Province, China.Department of Anesthesiology, Guizhou Provincial People's Hospital, Guiyang, China; Corresponding author.Department of Neurosurgery, Guizhou Provincial People's Hospital, Guiyang, China; Corresponding author.Whether receptor activity-modifying proteins (RAMPs) play a key role in human cancer prognosis and immunity remains unknown. We used data from the public databases, The Cancer Genome Atlas, Therapeutically Applicable Research to Generate Effective Treatments, and the Genotype-Tissue Expression project. We utilized bioinformatics methods, R software, and a variety of online databases to analyze RAMPs. In general, RAMPs were significantly and differentially expressed in multiple tumors, and RAMP expression was closely associated with prognosis, immune checkpoints, RNA-editing genes, tumor mutational burden, microsatellite instability, ploidy, and stemness indices. In addition, the expression of RAMPs is strongly correlated with tumor-infiltrating lymphocytes in human cancers. Moreover, the RAMP co-expression network is largely involved in many immune-related biological processes. Quantitative reverse transcription polymerase chain reaction and Western blot proved that RAMP3 was highly expressed in glioma, and RAMP3 promoted tumor proliferation and migration. RAMPs exhibit potential as prognostic and immune-related biomarkers in human cancers. Moreover, RAMPs can be potentially developed as therapeutic targets or used to enhance the efficacy of immunotherapy.http://www.sciencedirect.com/science/article/pii/S2405844024008806RAMPsPrognosisImmunotherapyPan-cancerImmuneTumor microenvironment |
| spellingShingle | Sha Yang Renzheng Huan Mei Deng Tao Luo Shuo Peng Yunbiao Xiong Guoqiang Han Jian Liu Jiqin Zhang Ying Tan Pan-cancer analysis revealed prognosis value and immunological relevance of RAMPs Heliyon RAMPs Prognosis Immunotherapy Pan-cancer Immune Tumor microenvironment |
| title | Pan-cancer analysis revealed prognosis value and immunological relevance of RAMPs |
| title_full | Pan-cancer analysis revealed prognosis value and immunological relevance of RAMPs |
| title_fullStr | Pan-cancer analysis revealed prognosis value and immunological relevance of RAMPs |
| title_full_unstemmed | Pan-cancer analysis revealed prognosis value and immunological relevance of RAMPs |
| title_short | Pan-cancer analysis revealed prognosis value and immunological relevance of RAMPs |
| title_sort | pan cancer analysis revealed prognosis value and immunological relevance of ramps |
| topic | RAMPs Prognosis Immunotherapy Pan-cancer Immune Tumor microenvironment |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024008806 |
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