Mammalian Base Excision Repair: Functional Partnership between PARP-1 and APE1 in AP-Site Repair.

Mammalian Base Excision Repair: Functional Partnership between PARP-1 and APE1 in AP-Site Repair.

The apurinic/apyrimidinic- (AP-) site in genomic DNA arises through spontaneous base loss and base removal by DNA glycosylases and is considered an abundant DNA lesion in mammalian cells. The base excision repair (BER) pathway repairs the AP-site lesion by excising and replacing the site with a norm...

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Bibliographic Details
Main Authors: Rajendra Prasad, Nadezhda Dyrkheeva, Jason Williams, Samuel H Wilson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4447435?pdf=render

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