The Evolution of Intracardiac Hemodynamics Post Autologous Stem Cell Transplant in a Case of Multiple Myeloma Associated with Severe Tricuspid and Mitral Valve Insufficiency
Stem cells are undifferentiated cells that can divide and become differentiated. Hematopoietic stem cells cannot transform into new stem cells such as cardiomyocytes or new heart valves, but they act through paracrine effects, by secreting cytokines and growth factors that lead to an increase in con...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2017-12-01
|
| Series: | Journal of Interdisciplinary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/jim-2017-0099 |
| _version_ | 1818582194102206464 |
|---|---|
| author | Tudor Cezara-Iuliana Lázár Erzsébet Găzdac Marius-Vasile Pakucs Annamária Mild Eszter Köpeczi Judit-Beáta Kakucs Enikő Benedek István Benedek István |
| author_facet | Tudor Cezara-Iuliana Lázár Erzsébet Găzdac Marius-Vasile Pakucs Annamária Mild Eszter Köpeczi Judit-Beáta Kakucs Enikő Benedek István Benedek István |
| author_sort | Tudor Cezara-Iuliana |
| collection | DOAJ |
| description | Stem cells are undifferentiated cells that can divide and become differentiated. Hematopoietic stem cells cannot transform into new stem cells such as cardiomyocytes or new heart valves, but they act through paracrine effects, by secreting cytokines and growth factors that lead to an increase in contractility and overall improved function. In this case report, we present how autologous stem cell transplantation can bring two major benefits: the first refers to hematological malignancy and the second is about the improvement of the heart condition. We present the case of a 60-year-old patient diagnosed with multiple myeloma suffering from a bi-valve severe condition in which autologous stem cell transplantation led to the remission of the patient’s malignant disease and also improved the heart function. |
| first_indexed | 2024-12-16T07:45:30Z |
| format | Article |
| id | doaj.art-a6e8c076439647f58970af4c3cca2239 |
| institution | Directory Open Access Journal |
| issn | 2501-8132 |
| language | English |
| last_indexed | 2024-12-16T07:45:30Z |
| publishDate | 2017-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Journal of Interdisciplinary Medicine |
| spelling | doaj.art-a6e8c076439647f58970af4c3cca22392022-12-21T22:38:58ZengSciendoJournal of Interdisciplinary Medicine2501-81322017-12-012s4454710.1515/jim-2017-0099jim-2017-0099The Evolution of Intracardiac Hemodynamics Post Autologous Stem Cell Transplant in a Case of Multiple Myeloma Associated with Severe Tricuspid and Mitral Valve InsufficiencyTudor Cezara-Iuliana0Lázár Erzsébet1Găzdac Marius-Vasile2Pakucs Annamária3Mild Eszter4Köpeczi Judit-Beáta5Kakucs Enikő6Benedek István7Benedek István8Clinic of Hematology and Bone Marrow Transplantation Unit, Tîrgu Mureş, RomaniaClinic of Hematology and Bone Marrow Transplantation Unit, Tîrgu Mureş, RomaniaClinic of Hematology and Bone Marrow Transplantation Unit, Tîrgu Mureş, RomaniaClinic of Hematology and Bone Marrow Transplantation Unit, Tîrgu Mureş, RomaniaClinic of Hematology and Bone Marrow Transplantation Unit, Tîrgu Mureş, RomaniaClinic of Hematology and Bone Marrow Transplantation Unit, Tîrgu Mureş, RomaniaClinic of Hematology and Bone Marrow Transplantation Unit, Tîrgu Mureş, RomaniaClinic of Hematology and Bone Marrow Transplantation Unit, Tîrgu Mureş, RomaniaClinic of Hematology and Bone Marrow Transplantation Unit, Tîrgu Mureş, RomaniaStem cells are undifferentiated cells that can divide and become differentiated. Hematopoietic stem cells cannot transform into new stem cells such as cardiomyocytes or new heart valves, but they act through paracrine effects, by secreting cytokines and growth factors that lead to an increase in contractility and overall improved function. In this case report, we present how autologous stem cell transplantation can bring two major benefits: the first refers to hematological malignancy and the second is about the improvement of the heart condition. We present the case of a 60-year-old patient diagnosed with multiple myeloma suffering from a bi-valve severe condition in which autologous stem cell transplantation led to the remission of the patient’s malignant disease and also improved the heart function.https://doi.org/10.1515/jim-2017-0099multiple myelomaautologous stem cell transplantationvalve insufficiency |
| spellingShingle | Tudor Cezara-Iuliana Lázár Erzsébet Găzdac Marius-Vasile Pakucs Annamária Mild Eszter Köpeczi Judit-Beáta Kakucs Enikő Benedek István Benedek István The Evolution of Intracardiac Hemodynamics Post Autologous Stem Cell Transplant in a Case of Multiple Myeloma Associated with Severe Tricuspid and Mitral Valve Insufficiency Journal of Interdisciplinary Medicine multiple myeloma autologous stem cell transplantation valve insufficiency |
| title | The Evolution of Intracardiac Hemodynamics Post Autologous Stem Cell Transplant in a Case of Multiple Myeloma Associated with Severe Tricuspid and Mitral Valve Insufficiency |
| title_full | The Evolution of Intracardiac Hemodynamics Post Autologous Stem Cell Transplant in a Case of Multiple Myeloma Associated with Severe Tricuspid and Mitral Valve Insufficiency |
| title_fullStr | The Evolution of Intracardiac Hemodynamics Post Autologous Stem Cell Transplant in a Case of Multiple Myeloma Associated with Severe Tricuspid and Mitral Valve Insufficiency |
| title_full_unstemmed | The Evolution of Intracardiac Hemodynamics Post Autologous Stem Cell Transplant in a Case of Multiple Myeloma Associated with Severe Tricuspid and Mitral Valve Insufficiency |
| title_short | The Evolution of Intracardiac Hemodynamics Post Autologous Stem Cell Transplant in a Case of Multiple Myeloma Associated with Severe Tricuspid and Mitral Valve Insufficiency |
| title_sort | evolution of intracardiac hemodynamics post autologous stem cell transplant in a case of multiple myeloma associated with severe tricuspid and mitral valve insufficiency |
| topic | multiple myeloma autologous stem cell transplantation valve insufficiency |
| url | https://doi.org/10.1515/jim-2017-0099 |
| work_keys_str_mv | AT tudorcezaraiuliana theevolutionofintracardiachemodynamicspostautologousstemcelltransplantinacaseofmultiplemyelomaassociatedwithseveretricuspidandmitralvalveinsufficiency AT lazarerzsebet theevolutionofintracardiachemodynamicspostautologousstemcelltransplantinacaseofmultiplemyelomaassociatedwithseveretricuspidandmitralvalveinsufficiency AT gazdacmariusvasile theevolutionofintracardiachemodynamicspostautologousstemcelltransplantinacaseofmultiplemyelomaassociatedwithseveretricuspidandmitralvalveinsufficiency AT pakucsannamaria theevolutionofintracardiachemodynamicspostautologousstemcelltransplantinacaseofmultiplemyelomaassociatedwithseveretricuspidandmitralvalveinsufficiency AT mildeszter theevolutionofintracardiachemodynamicspostautologousstemcelltransplantinacaseofmultiplemyelomaassociatedwithseveretricuspidandmitralvalveinsufficiency AT kopeczijuditbeata theevolutionofintracardiachemodynamicspostautologousstemcelltransplantinacaseofmultiplemyelomaassociatedwithseveretricuspidandmitralvalveinsufficiency AT kakucseniko theevolutionofintracardiachemodynamicspostautologousstemcelltransplantinacaseofmultiplemyelomaassociatedwithseveretricuspidandmitralvalveinsufficiency AT benedekistvan theevolutionofintracardiachemodynamicspostautologousstemcelltransplantinacaseofmultiplemyelomaassociatedwithseveretricuspidandmitralvalveinsufficiency AT benedekistvan theevolutionofintracardiachemodynamicspostautologousstemcelltransplantinacaseofmultiplemyelomaassociatedwithseveretricuspidandmitralvalveinsufficiency AT tudorcezaraiuliana evolutionofintracardiachemodynamicspostautologousstemcelltransplantinacaseofmultiplemyelomaassociatedwithseveretricuspidandmitralvalveinsufficiency AT lazarerzsebet evolutionofintracardiachemodynamicspostautologousstemcelltransplantinacaseofmultiplemyelomaassociatedwithseveretricuspidandmitralvalveinsufficiency AT gazdacmariusvasile evolutionofintracardiachemodynamicspostautologousstemcelltransplantinacaseofmultiplemyelomaassociatedwithseveretricuspidandmitralvalveinsufficiency AT pakucsannamaria evolutionofintracardiachemodynamicspostautologousstemcelltransplantinacaseofmultiplemyelomaassociatedwithseveretricuspidandmitralvalveinsufficiency AT mildeszter evolutionofintracardiachemodynamicspostautologousstemcelltransplantinacaseofmultiplemyelomaassociatedwithseveretricuspidandmitralvalveinsufficiency AT kopeczijuditbeata evolutionofintracardiachemodynamicspostautologousstemcelltransplantinacaseofmultiplemyelomaassociatedwithseveretricuspidandmitralvalveinsufficiency AT kakucseniko evolutionofintracardiachemodynamicspostautologousstemcelltransplantinacaseofmultiplemyelomaassociatedwithseveretricuspidandmitralvalveinsufficiency AT benedekistvan evolutionofintracardiachemodynamicspostautologousstemcelltransplantinacaseofmultiplemyelomaassociatedwithseveretricuspidandmitralvalveinsufficiency AT benedekistvan evolutionofintracardiachemodynamicspostautologousstemcelltransplantinacaseofmultiplemyelomaassociatedwithseveretricuspidandmitralvalveinsufficiency |