Can Targeting Hypoxia-Mediated Acidification of the Bone Marrow Microenvironment Kill Myeloma Tumor Cells?

Can Targeting Hypoxia-Mediated Acidification of the Bone Marrow Microenvironment Kill Myeloma Tumor Cells?

Multiple myeloma (MM) is an incurable cancer arising from malignant plasma cells that engraft in the bone marrow (BM). The physiology of these cancer cells within the BM microenvironment (TME) plays a critical role in MM development. These processes may be similar to what has been observed in the TM...

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Bibliographic Details
Main Authors: Gilberto Gastelum, Mysore Veena, Kylee Lyons, Christopher Lamb, Nicole Jacobs, Alexandra Yamada, Alisher Baibussinov, Martin Sarafyan, Rebeka Shamis, Jeffry Kraut, Patrick Frost
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
pH balance
acid base regulation
bone marrow microenvironment
hypoxia and apoptosis
multiple myeloma
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.703878/full

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