Disturbed integrin expression in the vascular media in CADASIL
CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is an inherited angiopathy characterized by degeneration and loss of vascular smooth muscle cells (VSMCs) of still unknown pathomechanism. Many functions of VSMCs, such as adhesion, apoptosis, contra...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2016-12-01
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| Series: | Folia Neuropathologica |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Disturbed-integrin-expression-in-the-vascular-media-in-CADASIL,20,28978,1,1.html |
| _version_ | 1819155433936388096 |
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| author | Dorota Dziewulska Ewelina Nycz |
| author_facet | Dorota Dziewulska Ewelina Nycz |
| author_sort | Dorota Dziewulska |
| collection | DOAJ |
| description | CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is an inherited angiopathy characterized by degeneration and loss of vascular smooth muscle cells (VSMCs) of still unknown pathomechanism. Many functions of VSMCs, such as adhesion, apoptosis, contraction, differentiation, migration, and proliferation are determined by integrins – surface adhesion receptors involved in binding and interactions between cells and extracellular matrix (ECM). Since integrins play such an important role in VSMCs biology, disturbances in their expression may influence myocytes behavior and fate in CADASIL. In this study, we focused on the most important compounds of VSMCs integrins: subunits α 4 , β1, and β 3 in an attempt to elucidate their immune expression in the arterial media of CADASIL patients. The immunohistochemistry revealed a decreased expression of integrin β1 subunit (p < 0.001) but similar to the control expression of integrin subunits α 4 and β 3 . Decreased β1 immunoreactivity was observed in capillary vessels, arterioles, and small arteries. The abnormal immune expression of integrin β1 subunit was found even in microvessels without microscopically noted degenerative changes, which suggests that this is an early phenomenon in CADASIL. Since integrin β1 subunit is a compound of 10 heterodimer integrin receptors, its disturbed expression may significantly influence VSMCs biology leading to myocytes degeneration and loss via anoikis – a type of apoptotic cell death due to loss or inappropriate cell adhesion to ECM. |
| first_indexed | 2024-12-22T15:36:54Z |
| format | Article |
| id | doaj.art-a6eb8a4fb6b444489e21196708ab1acb |
| institution | Directory Open Access Journal |
| issn | 1641-4640 1509-572X |
| language | English |
| last_indexed | 2024-12-22T15:36:54Z |
| publishDate | 2016-12-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Folia Neuropathologica |
| spelling | doaj.art-a6eb8a4fb6b444489e21196708ab1acb2022-12-21T18:21:13ZengTermedia Publishing HouseFolia Neuropathologica1641-46401509-572X2016-12-0154437538110.5114/fn.2016.6481628978Disturbed integrin expression in the vascular media in CADASILDorota DziewulskaEwelina NyczCADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is an inherited angiopathy characterized by degeneration and loss of vascular smooth muscle cells (VSMCs) of still unknown pathomechanism. Many functions of VSMCs, such as adhesion, apoptosis, contraction, differentiation, migration, and proliferation are determined by integrins – surface adhesion receptors involved in binding and interactions between cells and extracellular matrix (ECM). Since integrins play such an important role in VSMCs biology, disturbances in their expression may influence myocytes behavior and fate in CADASIL. In this study, we focused on the most important compounds of VSMCs integrins: subunits α 4 , β1, and β 3 in an attempt to elucidate their immune expression in the arterial media of CADASIL patients. The immunohistochemistry revealed a decreased expression of integrin β1 subunit (p < 0.001) but similar to the control expression of integrin subunits α 4 and β 3 . Decreased β1 immunoreactivity was observed in capillary vessels, arterioles, and small arteries. The abnormal immune expression of integrin β1 subunit was found even in microvessels without microscopically noted degenerative changes, which suggests that this is an early phenomenon in CADASIL. Since integrin β1 subunit is a compound of 10 heterodimer integrin receptors, its disturbed expression may significantly influence VSMCs biology leading to myocytes degeneration and loss via anoikis – a type of apoptotic cell death due to loss or inappropriate cell adhesion to ECM.https://www.termedia.pl/Disturbed-integrin-expression-in-the-vascular-media-in-CADASIL,20,28978,1,1.htmlCADASIL integrin microangiopathy tunica media vascular smooth muscle |
| spellingShingle | Dorota Dziewulska Ewelina Nycz Disturbed integrin expression in the vascular media in CADASIL Folia Neuropathologica CADASIL integrin microangiopathy tunica media vascular smooth muscle |
| title | Disturbed integrin expression in the vascular media in CADASIL |
| title_full | Disturbed integrin expression in the vascular media in CADASIL |
| title_fullStr | Disturbed integrin expression in the vascular media in CADASIL |
| title_full_unstemmed | Disturbed integrin expression in the vascular media in CADASIL |
| title_short | Disturbed integrin expression in the vascular media in CADASIL |
| title_sort | disturbed integrin expression in the vascular media in cadasil |
| topic | CADASIL integrin microangiopathy tunica media vascular smooth muscle |
| url | https://www.termedia.pl/Disturbed-integrin-expression-in-the-vascular-media-in-CADASIL,20,28978,1,1.html |
| work_keys_str_mv | AT dorotadziewulska disturbedintegrinexpressioninthevascularmediaincadasil AT ewelinanycz disturbedintegrinexpressioninthevascularmediaincadasil |