The Possible beneficial effects of Antioxidant drugs (Vitamin C and E) and Allopurinol in the management of Pre-eclamptic patients treated with Methyldopa.
Background: Pre-eclampsia is culmination of a multi-step process that related in part to elevated oxidative stress and associated with hyperurecimia. Patients and methods: Thirty normotensive and hundred pre-eclamptic pregnant women attending to Al-Basra hospital of pediatrics, obstetrics and gyneco...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2010-04-01
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| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1066 |
| _version_ | 1797368051444744192 |
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| author | Ghassan S. Ahmed May S. Al-Sabbagh |
| author_facet | Ghassan S. Ahmed May S. Al-Sabbagh |
| author_sort | Ghassan S. Ahmed |
| collection | DOAJ |
| description | Background: Pre-eclampsia is culmination of a multi-step process that related in part to elevated oxidative stress and associated with hyperurecimia.
Patients and methods: Thirty normotensive and hundred pre-eclamptic pregnant women attending to Al-Basra hospital of pediatrics, obstetrics and gynecology were participated in this study. The patients were randomized into six groups. They were treated with methyldopa alone, methyldopa plus vitamin C, methyldopa plus vitamin E, methyldopa plus vitamin C and E, and methyldopa plus allopurinol. The oxidative stress (MDA), renal function parameters, systolic and diastolic blood pressure were evaluated before treatment and 14 day after initiation of therapy.
Results: Using allopurinol, vitamin C, vitamin E, and a combination of vitamin C and E together with methyldopa in pre-eclampsia can produce a significant reduction in the level of oxidative stress, on the other hand, some of these supplemental antioxidants can produce a significant reduction in systolic and diastolic blood pressures, serum creatinine and proteinurea as well as serum uric acid concentration in different extent.
Conclusion: Antioxidants and allopurinol when co-administrated with methyldopa, improves the maternal and biochemical indicators of pre-eclampsia and produce a better control of blood pressure. |
| first_indexed | 2024-03-08T17:26:52Z |
| format | Article |
| id | doaj.art-a6ed91f5c952434b9bf722a45cc3e2cb |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T17:26:52Z |
| publishDate | 2010-04-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-a6ed91f5c952434b9bf722a45cc3e2cb2024-01-02T18:43:54ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572010-04-0152110.32007/jfacmedbagdad.v190-94%The Possible beneficial effects of Antioxidant drugs (Vitamin C and E) and Allopurinol in the management of Pre-eclamptic patients treated with Methyldopa.Ghassan S. Ahmed0May S. Al-Sabbagh1Dept. of Clinical Pharmacy and Pharmaceutics/College of Pharmacy/University of Basra.Dept. of Clinical Pharmacy /College of Pharmacy/ University of Baghdad.Background: Pre-eclampsia is culmination of a multi-step process that related in part to elevated oxidative stress and associated with hyperurecimia. Patients and methods: Thirty normotensive and hundred pre-eclamptic pregnant women attending to Al-Basra hospital of pediatrics, obstetrics and gynecology were participated in this study. The patients were randomized into six groups. They were treated with methyldopa alone, methyldopa plus vitamin C, methyldopa plus vitamin E, methyldopa plus vitamin C and E, and methyldopa plus allopurinol. The oxidative stress (MDA), renal function parameters, systolic and diastolic blood pressure were evaluated before treatment and 14 day after initiation of therapy. Results: Using allopurinol, vitamin C, vitamin E, and a combination of vitamin C and E together with methyldopa in pre-eclampsia can produce a significant reduction in the level of oxidative stress, on the other hand, some of these supplemental antioxidants can produce a significant reduction in systolic and diastolic blood pressures, serum creatinine and proteinurea as well as serum uric acid concentration in different extent. Conclusion: Antioxidants and allopurinol when co-administrated with methyldopa, improves the maternal and biochemical indicators of pre-eclampsia and produce a better control of blood pressure.http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1066Pre-eclampsia, Antioxidants, Oxidative stress, Vitamin C, Vitamin E, Allopurinol. |
| spellingShingle | Ghassan S. Ahmed May S. Al-Sabbagh The Possible beneficial effects of Antioxidant drugs (Vitamin C and E) and Allopurinol in the management of Pre-eclamptic patients treated with Methyldopa. مجلة كلية الطب Pre-eclampsia, Antioxidants, Oxidative stress, Vitamin C, Vitamin E, Allopurinol. |
| title | The Possible beneficial effects of Antioxidant drugs (Vitamin C and E) and Allopurinol in the management of Pre-eclamptic patients treated with Methyldopa. |
| title_full | The Possible beneficial effects of Antioxidant drugs (Vitamin C and E) and Allopurinol in the management of Pre-eclamptic patients treated with Methyldopa. |
| title_fullStr | The Possible beneficial effects of Antioxidant drugs (Vitamin C and E) and Allopurinol in the management of Pre-eclamptic patients treated with Methyldopa. |
| title_full_unstemmed | The Possible beneficial effects of Antioxidant drugs (Vitamin C and E) and Allopurinol in the management of Pre-eclamptic patients treated with Methyldopa. |
| title_short | The Possible beneficial effects of Antioxidant drugs (Vitamin C and E) and Allopurinol in the management of Pre-eclamptic patients treated with Methyldopa. |
| title_sort | possible beneficial effects of antioxidant drugs vitamin c and e and allopurinol in the management of pre eclamptic patients treated with methyldopa |
| topic | Pre-eclampsia, Antioxidants, Oxidative stress, Vitamin C, Vitamin E, Allopurinol. |
| url | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1066 |
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