AbeTx1 Is a Novel Sea Anemone Toxin with a Dual Mechanism of Action on Shaker-Type K+ Channels Activation

AbeTx1 Is a Novel Sea Anemone Toxin with a Dual Mechanism of Action on Shaker-Type K+ Channels Activation

Voltage-gated potassium (KV) channels regulate diverse physiological processes and are an important target for developing novel therapeutic approaches. Sea anemone (Cnidaria, Anthozoa) venoms comprise a highly complex mixture of peptide toxins with diverse and selective pharmacology on KV channels....

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Bibliographic Details
Main Authors: Diego J. B. Orts, Steve Peigneur, Laíz Costa Silva-Gonçalves, Manoel Arcisio-Miranda, José Eduardo P. W. Bicudo, Jan Tytgat
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Marine Drugs
Subjects:
sea anemone neurotoxin
Actinia bermudensis
potassium channel
type 6 KV-toxins
Alanine point mutation
Online Access:http://www.mdpi.com/1660-3397/16/10/360

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