Excess Mortality Associated with Antimicrobial Drug-Resistant Salmonella Typhimurium
In a matched cohort study, we determined the death rates associated with drug resistance in Salmonella Typhimurium. We linked data from the Danish Surveillance Registry for Enteric Pathogens with the Civil Registration System and the Danish National Discharge Registry. By survival analysis, the 2-ye...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2002-05-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/8/5/01-0267_article |
| _version_ | 1828520447639027712 |
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| author | Morten Helms Pernille Vastrup Peter Gerner-Smidt Kåre Mølbak |
| author_facet | Morten Helms Pernille Vastrup Peter Gerner-Smidt Kåre Mølbak |
| author_sort | Morten Helms |
| collection | DOAJ |
| description | In a matched cohort study, we determined the death rates associated with drug resistance in Salmonella Typhimurium. We linked data from the Danish Surveillance Registry for Enteric Pathogens with the Civil Registration System and the Danish National Discharge Registry. By survival analysis, the 2-year death rates were compared with a matched sample of the general Danish population, after the data were adjusted for differences in comorbidity. In 2,047 patients with S. Typhimurium, 59 deaths were identified. Patients with pansusceptible strains of S. Typhimurium were 2.3 times more likely to die 2 years after infection than persons in the general Danish population. Patients infected with strains resistant to ampicillin, chloramphenicol, streptomycin, sulfonamide, and tetracycline were 4.8 times (95% CI 2.2 to 10.2) more likely to die, whereas quinolone resistance was associated with a mortality rate 10.3 times higher than the general population. |
| first_indexed | 2024-12-11T19:31:05Z |
| format | Article |
| id | doaj.art-a6ef64136c8342d586a08a8925dfc999 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-11T19:31:05Z |
| publishDate | 2002-05-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-a6ef64136c8342d586a08a8925dfc9992022-12-22T00:53:17ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592002-05-018549049510.3201/eid0805.010267Excess Mortality Associated with Antimicrobial Drug-Resistant Salmonella TyphimuriumMorten HelmsPernille VastrupPeter Gerner-SmidtKåre MølbakIn a matched cohort study, we determined the death rates associated with drug resistance in Salmonella Typhimurium. We linked data from the Danish Surveillance Registry for Enteric Pathogens with the Civil Registration System and the Danish National Discharge Registry. By survival analysis, the 2-year death rates were compared with a matched sample of the general Danish population, after the data were adjusted for differences in comorbidity. In 2,047 patients with S. Typhimurium, 59 deaths were identified. Patients with pansusceptible strains of S. Typhimurium were 2.3 times more likely to die 2 years after infection than persons in the general Danish population. Patients infected with strains resistant to ampicillin, chloramphenicol, streptomycin, sulfonamide, and tetracycline were 4.8 times (95% CI 2.2 to 10.2) more likely to die, whereas quinolone resistance was associated with a mortality rate 10.3 times higher than the general population.https://wwwnc.cdc.gov/eid/article/8/5/01-0267_articleDenmarkdrug-resistancemortalityquinolonesSalmonellaserotype Typhimurium |
| spellingShingle | Morten Helms Pernille Vastrup Peter Gerner-Smidt Kåre Mølbak Excess Mortality Associated with Antimicrobial Drug-Resistant Salmonella Typhimurium Emerging Infectious Diseases Denmark drug-resistance mortality quinolones Salmonella serotype Typhimurium |
| title | Excess Mortality Associated with Antimicrobial Drug-Resistant Salmonella Typhimurium |
| title_full | Excess Mortality Associated with Antimicrobial Drug-Resistant Salmonella Typhimurium |
| title_fullStr | Excess Mortality Associated with Antimicrobial Drug-Resistant Salmonella Typhimurium |
| title_full_unstemmed | Excess Mortality Associated with Antimicrobial Drug-Resistant Salmonella Typhimurium |
| title_short | Excess Mortality Associated with Antimicrobial Drug-Resistant Salmonella Typhimurium |
| title_sort | excess mortality associated with antimicrobial drug resistant salmonella typhimurium |
| topic | Denmark drug-resistance mortality quinolones Salmonella serotype Typhimurium |
| url | https://wwwnc.cdc.gov/eid/article/8/5/01-0267_article |
| work_keys_str_mv | AT mortenhelms excessmortalityassociatedwithantimicrobialdrugresistantsalmonellatyphimurium AT pernillevastrup excessmortalityassociatedwithantimicrobialdrugresistantsalmonellatyphimurium AT petergernersmidt excessmortalityassociatedwithantimicrobialdrugresistantsalmonellatyphimurium AT karemølbak excessmortalityassociatedwithantimicrobialdrugresistantsalmonellatyphimurium |