Genomic clustering within functionally related gene families in Ascomycota fungi
Multiple mechanisms collaborate for proper regulation of gene expression. One layer of this regulation is through the clustering of functionally related genes at discrete loci throughout the genome. This phenomenon occurs extensively throughout Ascomycota fungi and is an organizing principle for man...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Computational and Structural Biotechnology Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037020304426 |
| _version_ | 1818414390043475968 |
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| author | Danielle Hagee Ahmad Abu Hardan Juan Botero James T. Arnone |
| author_facet | Danielle Hagee Ahmad Abu Hardan Juan Botero James T. Arnone |
| author_sort | Danielle Hagee |
| collection | DOAJ |
| description | Multiple mechanisms collaborate for proper regulation of gene expression. One layer of this regulation is through the clustering of functionally related genes at discrete loci throughout the genome. This phenomenon occurs extensively throughout Ascomycota fungi and is an organizing principle for many gene families whose proteins participate in diverse molecular functions throughout the cell. Members of this phylum include organisms that serve as model systems and those of interest medically, pharmaceutically, and for industrial and biotechnological applications. In this review, we discuss the prevalence of functional clustering through a broad range of organisms within the phylum. Position effects on transcription, genomic locations of clusters, transcriptional regulation of clusters, and selective pressures contributing to the formation and maintenance of clusters are addressed, as are common methods to identify and characterize clusters. |
| first_indexed | 2024-12-14T11:18:20Z |
| format | Article |
| id | doaj.art-a6f0b737ce04405db83af3b323e4cd84 |
| institution | Directory Open Access Journal |
| issn | 2001-0370 |
| language | English |
| last_indexed | 2024-12-14T11:18:20Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj.art-a6f0b737ce04405db83af3b323e4cd842022-12-21T23:03:55ZengElsevierComputational and Structural Biotechnology Journal2001-03702020-01-011832673277Genomic clustering within functionally related gene families in Ascomycota fungiDanielle Hagee0Ahmad Abu Hardan1Juan Botero2James T. Arnone3Department of Biology, William Paterson University, Wayne, NJ 07470, USADepartment of Biology, William Paterson University, Wayne, NJ 07470, USADepartment of Biology, William Paterson University, Wayne, NJ 07470, USACorresponding author at: Department of Biology, William Paterson University, 300 Pompton Road, Wayne, NJ 07470, USA.; Department of Biology, William Paterson University, Wayne, NJ 07470, USAMultiple mechanisms collaborate for proper regulation of gene expression. One layer of this regulation is through the clustering of functionally related genes at discrete loci throughout the genome. This phenomenon occurs extensively throughout Ascomycota fungi and is an organizing principle for many gene families whose proteins participate in diverse molecular functions throughout the cell. Members of this phylum include organisms that serve as model systems and those of interest medically, pharmaceutically, and for industrial and biotechnological applications. In this review, we discuss the prevalence of functional clustering through a broad range of organisms within the phylum. Position effects on transcription, genomic locations of clusters, transcriptional regulation of clusters, and selective pressures contributing to the formation and maintenance of clusters are addressed, as are common methods to identify and characterize clusters.http://www.sciencedirect.com/science/article/pii/S2001037020304426Biosynthetic gene clustersMetabolic gene clustersSecondary metabolite gene clustersAscomycota fungiGenomics |
| spellingShingle | Danielle Hagee Ahmad Abu Hardan Juan Botero James T. Arnone Genomic clustering within functionally related gene families in Ascomycota fungi Computational and Structural Biotechnology Journal Biosynthetic gene clusters Metabolic gene clusters Secondary metabolite gene clusters Ascomycota fungi Genomics |
| title | Genomic clustering within functionally related gene families in Ascomycota fungi |
| title_full | Genomic clustering within functionally related gene families in Ascomycota fungi |
| title_fullStr | Genomic clustering within functionally related gene families in Ascomycota fungi |
| title_full_unstemmed | Genomic clustering within functionally related gene families in Ascomycota fungi |
| title_short | Genomic clustering within functionally related gene families in Ascomycota fungi |
| title_sort | genomic clustering within functionally related gene families in ascomycota fungi |
| topic | Biosynthetic gene clusters Metabolic gene clusters Secondary metabolite gene clusters Ascomycota fungi Genomics |
| url | http://www.sciencedirect.com/science/article/pii/S2001037020304426 |
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