Synthesis and Bioactivity of 3-(2,4-Dichlorophenyl)-5-(4-Hydroxy-3-Methoxyphenyl) Pyrazoline
Pyrazoline is a five-ring heterocyclic compound having 3 carbon atoms and 2 nitrogen atoms known to have some biological activity. This study aims to synthesize 3-(2,4-dichlorophenyl)-5-(4-hydroxy-3-methoxyphenyl) pyrazoline using 2’,4’-dichloro-4-hydroxy-3-methoxy chalcone and hydrazine. Synthe...
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| Format: | Article |
| Language: | English |
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Mulawarman University
2018-12-01
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| Series: | Journal of Tropical Pharmacy and Chemistry |
| Subjects: | |
| Online Access: | https://jtpc.farmasi.unmul.ac.id/index.php/jtpc/article/view/183 |
| _version_ | 1827771101482057728 |
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| author | Nurul Khotimah Agung Rahmadani Dewi Rahmawati Mirhansyah Ardana |
| author_facet | Nurul Khotimah Agung Rahmadani Dewi Rahmawati Mirhansyah Ardana |
| author_sort | Nurul Khotimah |
| collection | DOAJ |
| description | Pyrazoline is a five-ring heterocyclic compound having 3 carbon atoms and 2 nitrogen atoms known to have some biological activity. This study aims to synthesize 3-(2,4-dichlorophenyl)-5-(4-hydroxy-3-methoxyphenyl) pyrazoline using 2’,4’-dichloro-4-hydroxy-3-methoxy chalcone and hydrazine. Synthesis was performed by reflux method at 80oC for 7 hours. The synthesis compounds were characterized by structural elucidation techniques. From the synthesis results obtained compound 3-(2,4-dichlorophenyl)-5-(4-hydroxy-3-methoxyphenyl) Pyrazoline is pale yellow powder with 84%yield. The result of antioxidant activity test by 2,2-diphenyl-1-picrylhydrazyl (DPPH) showed that the compound had very strong antioxidant activity, Antibacterial test by diffusion method to use paper disk showed that the compound had antibacterial activity against Gram positive bacteria (S.aureus) and Gram negative bacteria (E.coli) and toxicity test by Brine Shrimp Lethality Test (BSLT) showed that the compound had toxicity.
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| first_indexed | 2024-03-11T12:48:53Z |
| format | Article |
| id | doaj.art-a6f1ccb1e6704f51a0a67dc6c5b0e0c1 |
| institution | Directory Open Access Journal |
| issn | 2087-7099 2407-6090 |
| language | English |
| last_indexed | 2024-03-11T12:48:53Z |
| publishDate | 2018-12-01 |
| publisher | Mulawarman University |
| record_format | Article |
| series | Journal of Tropical Pharmacy and Chemistry |
| spelling | doaj.art-a6f1ccb1e6704f51a0a67dc6c5b0e0c12023-11-04T06:12:06ZengMulawarman UniversityJournal of Tropical Pharmacy and Chemistry2087-70992407-60902018-12-014410.25026/jtpc.v4i4.183Synthesis and Bioactivity of 3-(2,4-Dichlorophenyl)-5-(4-Hydroxy-3-Methoxyphenyl) PyrazolineNurul Khotimah0Agung Rahmadani1Dewi Rahmawati2Mirhansyah Ardana3Laboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, IndonesiaLaboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, IndonesiaLaboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, IndonesiaLaboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, IndonesiaPyrazoline is a five-ring heterocyclic compound having 3 carbon atoms and 2 nitrogen atoms known to have some biological activity. This study aims to synthesize 3-(2,4-dichlorophenyl)-5-(4-hydroxy-3-methoxyphenyl) pyrazoline using 2’,4’-dichloro-4-hydroxy-3-methoxy chalcone and hydrazine. Synthesis was performed by reflux method at 80oC for 7 hours. The synthesis compounds were characterized by structural elucidation techniques. From the synthesis results obtained compound 3-(2,4-dichlorophenyl)-5-(4-hydroxy-3-methoxyphenyl) Pyrazoline is pale yellow powder with 84%yield. The result of antioxidant activity test by 2,2-diphenyl-1-picrylhydrazyl (DPPH) showed that the compound had very strong antioxidant activity, Antibacterial test by diffusion method to use paper disk showed that the compound had antibacterial activity against Gram positive bacteria (S.aureus) and Gram negative bacteria (E.coli) and toxicity test by Brine Shrimp Lethality Test (BSLT) showed that the compound had toxicity. https://jtpc.farmasi.unmul.ac.id/index.php/jtpc/article/view/183synthesis, pyrazoline, antibacterial, antioxidant, toxicity |
| spellingShingle | Nurul Khotimah Agung Rahmadani Dewi Rahmawati Mirhansyah Ardana Synthesis and Bioactivity of 3-(2,4-Dichlorophenyl)-5-(4-Hydroxy-3-Methoxyphenyl) Pyrazoline Journal of Tropical Pharmacy and Chemistry synthesis, pyrazoline, antibacterial, antioxidant, toxicity |
| title | Synthesis and Bioactivity of 3-(2,4-Dichlorophenyl)-5-(4-Hydroxy-3-Methoxyphenyl) Pyrazoline |
| title_full | Synthesis and Bioactivity of 3-(2,4-Dichlorophenyl)-5-(4-Hydroxy-3-Methoxyphenyl) Pyrazoline |
| title_fullStr | Synthesis and Bioactivity of 3-(2,4-Dichlorophenyl)-5-(4-Hydroxy-3-Methoxyphenyl) Pyrazoline |
| title_full_unstemmed | Synthesis and Bioactivity of 3-(2,4-Dichlorophenyl)-5-(4-Hydroxy-3-Methoxyphenyl) Pyrazoline |
| title_short | Synthesis and Bioactivity of 3-(2,4-Dichlorophenyl)-5-(4-Hydroxy-3-Methoxyphenyl) Pyrazoline |
| title_sort | synthesis and bioactivity of 3 2 4 dichlorophenyl 5 4 hydroxy 3 methoxyphenyl pyrazoline |
| topic | synthesis, pyrazoline, antibacterial, antioxidant, toxicity |
| url | https://jtpc.farmasi.unmul.ac.id/index.php/jtpc/article/view/183 |
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