Inhibition of GSDMD-mediated pyroptosis triggered by Trichinella spiralis intervention contributes to the alleviation of DSS-induced ulcerative colitis in mice

Inhibition of GSDMD-mediated pyroptosis triggered by Trichinella spiralis intervention contributes to the alleviation of DSS-induced ulcerative colitis in mice

Abstract Background Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), is increasing worldwide. Although there is currently no completely curative treatment, helminthic therapy shows certain therapeutic potential for UC. Many studies have found that Trichin...

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Bibliographic Details
Main Authors: Zhen-Rong Ma, Zhuo-Lin Li, Ni Zhang, Bin Lu, Xuan-Wu Li, Ye-Hong Huang, Dibo Nouhoum, Xian-Shu Liu, Ke-Chun Xiao, Li-Ting Cai, Shao-Rui Xu, Xue-Xian O. Yang, Shuai-Qin Huang, Xiang Wu
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Parasites & Vectors
Subjects:
Trichinella spiralis
Protective effect
Ulcerative colitis
Inhibition
GSDMD-mediated pyroptosis
Online Access:https://doi.org/10.1186/s13071-023-05857-3

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