Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022?
Celiac disease (CD) is a chronic, small-intestinal, immune-mediated enteropathy due to gluten exposition in genetically predisposed individuals. It occurs in about 1% of the population and often remains an underdiagnosed condition. This could be due to the fact that the adult population often lacks...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/1/258 |
| _version_ | 1797498620197470208 |
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| author | Marilena Durazzo Arianna Ferro Isabella Brascugli Simone Mattivi Sharmila Fagoonee Rinaldo Pellicano |
| author_facet | Marilena Durazzo Arianna Ferro Isabella Brascugli Simone Mattivi Sharmila Fagoonee Rinaldo Pellicano |
| author_sort | Marilena Durazzo |
| collection | DOAJ |
| description | Celiac disease (CD) is a chronic, small-intestinal, immune-mediated enteropathy due to gluten exposition in genetically predisposed individuals. It occurs in about 1% of the population and often remains an underdiagnosed condition. This could be due to the fact that the adult population often lacks the classical signs and symptoms of CD, manifesting only atypical symptoms. In this review we analyzed the main extra-intestinal manifestations of CD which include cutaneous and endocrinological disorders, abnormal liver function tests, and neuropsychiatric features. When CD is not diagnosed and therefore is not treated with a gluten-free diet (GFD), it can predispose to severe complications, not only gastrointestinal. Thus, it is important for clinicians to quickly recognize the atypical manifestations of CD, considering that an early diagnosis can significantly impact on a patient’s prognosis. |
| first_indexed | 2024-03-10T03:35:56Z |
| format | Article |
| id | doaj.art-a6f4325e3248457ab9d76e6364c70d3c |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T03:35:56Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-a6f4325e3248457ab9d76e6364c70d3c2023-11-23T11:46:09ZengMDPI AGJournal of Clinical Medicine2077-03832022-01-0111125810.3390/jcm11010258Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022?Marilena Durazzo0Arianna Ferro1Isabella Brascugli2Simone Mattivi3Sharmila Fagoonee4Rinaldo Pellicano5Department of Medical Sciences, University of Turin, C.so A.M. Dogliotti 14, 10126 Turin, ItalyDepartment of Medical Sciences, University of Turin, C.so A.M. Dogliotti 14, 10126 Turin, ItalyDepartment of Medical Sciences, University of Turin, C.so A.M. Dogliotti 14, 10126 Turin, ItalyDepartment of Medical Sciences, University of Turin, C.so A.M. Dogliotti 14, 10126 Turin, ItalyInstitute for Biostructure and Bioimaging, National Research Council, Molecular Biotechnology Centre, 10126 Turin, ItalyUnit of Gastroenterology, Città della Salute e della Scienza Hospital, C.so Bramante 88, 10126 Turin, ItalyCeliac disease (CD) is a chronic, small-intestinal, immune-mediated enteropathy due to gluten exposition in genetically predisposed individuals. It occurs in about 1% of the population and often remains an underdiagnosed condition. This could be due to the fact that the adult population often lacks the classical signs and symptoms of CD, manifesting only atypical symptoms. In this review we analyzed the main extra-intestinal manifestations of CD which include cutaneous and endocrinological disorders, abnormal liver function tests, and neuropsychiatric features. When CD is not diagnosed and therefore is not treated with a gluten-free diet (GFD), it can predispose to severe complications, not only gastrointestinal. Thus, it is important for clinicians to quickly recognize the atypical manifestations of CD, considering that an early diagnosis can significantly impact on a patient’s prognosis.https://www.mdpi.com/2077-0383/11/1/258celiac diseaseextraintestinaldiagnosisclinical presentationgluten-free diet |
| spellingShingle | Marilena Durazzo Arianna Ferro Isabella Brascugli Simone Mattivi Sharmila Fagoonee Rinaldo Pellicano Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022? Journal of Clinical Medicine celiac disease extraintestinal diagnosis clinical presentation gluten-free diet |
| title | Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022? |
| title_full | Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022? |
| title_fullStr | Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022? |
| title_full_unstemmed | Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022? |
| title_short | Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022? |
| title_sort | extra intestinal manifestations of celiac disease what should we know in 2022 |
| topic | celiac disease extraintestinal diagnosis clinical presentation gluten-free diet |
| url | https://www.mdpi.com/2077-0383/11/1/258 |
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