Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas
The majority of non-melanoma skin cancer (NMSC) is cutaneous basal cell carcinoma (BCC) or squamous cell carcinoma (SCC), which are also called keratinocyte carcinomas, as both of them originate from keratinocytes. The incidence of keratinocyte carcinomas is over 5 million per year in the US, three-...
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KeAi Communications Co., Ltd.
2021-03-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304219300911 |
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| author | Jun Wan Hongji Dai Xiaoli Zhang Sheng Liu Yuan Lin Ally-Khan Somani Jingwu Xie Jiali Han |
| author_facet | Jun Wan Hongji Dai Xiaoli Zhang Sheng Liu Yuan Lin Ally-Khan Somani Jingwu Xie Jiali Han |
| author_sort | Jun Wan |
| collection | DOAJ |
| description | The majority of non-melanoma skin cancer (NMSC) is cutaneous basal cell carcinoma (BCC) or squamous cell carcinoma (SCC), which are also called keratinocyte carcinomas, as both of them originate from keratinocytes. The incidence of keratinocyte carcinomas is over 5 million per year in the US, three-fold higher than the total incidence of all other types of cancer combined. While there are several reports on gene expression profiling of BCC and SCC, there are significant variations in the reported gene expression changes in different studies. One reason is that tumor-adjacent normal skin specimens were not included in many studies as matched controls. Furthermore, while numerous studies of skin stem cells in mouse models have been reported, their relevance to human skin cancer remains unknown. In this report, we analyzed gene expression profiles of paired specimens of keratinocyte carcinomas with their matched normal skin tissues as the control. Among several novel findings, we discovered a significant number of zinc finger encoding genes up-regulated in human BCC. In BCC, a novel link was found between hedgehog signaling, Wnt signaling, and the cilium. While the SCC cancer-stem-cell gene signature is shared between human and mouse SCCs, the hair follicle stem-cell signature of mice was not highly represented in human SCC. Differential gene expression (DEG) in human BCC shares gene signature with both bulge and epidermal stem cells. We have also determined that human BCCs and SCCs have distinct gene expression patterns, and some of them are not fully reflected in current mouse models. |
| first_indexed | 2024-03-12T09:39:21Z |
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| id | doaj.art-a6f4ba1b10cc463b8a3b62bcfc63585e |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2024-03-12T09:39:21Z |
| publishDate | 2021-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-a6f4ba1b10cc463b8a3b62bcfc63585e2023-09-02T13:22:14ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422021-03-0182181192Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomasJun Wan0Hongji Dai1Xiaoli Zhang2Sheng Liu3Yuan Lin4Ally-Khan Somani5Jingwu Xie6Jiali Han7Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA; School of Informatics and Computing, Indiana University – Purdue University at Indianapolis, Indianapolis, IN, 46202, USADepartment of Epidemiology and Biostatistics, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center of Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300000, PR ChinaWells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA; Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USADepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, 46202, USADepartment of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN, 46202, USADermatologic Surgery & Cutaneous Oncology Division, Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, 46202, USAWells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA; Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA; Corresponding author.Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, 46202, USA; Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN, 46202, USA; Corresponding author.The majority of non-melanoma skin cancer (NMSC) is cutaneous basal cell carcinoma (BCC) or squamous cell carcinoma (SCC), which are also called keratinocyte carcinomas, as both of them originate from keratinocytes. The incidence of keratinocyte carcinomas is over 5 million per year in the US, three-fold higher than the total incidence of all other types of cancer combined. While there are several reports on gene expression profiling of BCC and SCC, there are significant variations in the reported gene expression changes in different studies. One reason is that tumor-adjacent normal skin specimens were not included in many studies as matched controls. Furthermore, while numerous studies of skin stem cells in mouse models have been reported, their relevance to human skin cancer remains unknown. In this report, we analyzed gene expression profiles of paired specimens of keratinocyte carcinomas with their matched normal skin tissues as the control. Among several novel findings, we discovered a significant number of zinc finger encoding genes up-regulated in human BCC. In BCC, a novel link was found between hedgehog signaling, Wnt signaling, and the cilium. While the SCC cancer-stem-cell gene signature is shared between human and mouse SCCs, the hair follicle stem-cell signature of mice was not highly represented in human SCC. Differential gene expression (DEG) in human BCC shares gene signature with both bulge and epidermal stem cells. We have also determined that human BCCs and SCCs have distinct gene expression patterns, and some of them are not fully reflected in current mouse models.http://www.sciencedirect.com/science/article/pii/S2352304219300911Basal cell carcinomaGli1Hedgehog signalingPTCH1Squamous cell carcinoma |
| spellingShingle | Jun Wan Hongji Dai Xiaoli Zhang Sheng Liu Yuan Lin Ally-Khan Somani Jingwu Xie Jiali Han Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas Genes and Diseases Basal cell carcinoma Gli1 Hedgehog signaling PTCH1 Squamous cell carcinoma |
| title | Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas |
| title_full | Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas |
| title_fullStr | Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas |
| title_full_unstemmed | Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas |
| title_short | Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas |
| title_sort | distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas |
| topic | Basal cell carcinoma Gli1 Hedgehog signaling PTCH1 Squamous cell carcinoma |
| url | http://www.sciencedirect.com/science/article/pii/S2352304219300911 |
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