Lower Expression of <i>CFTR</i> Is Associated with Higher Mortality in a Meta-Analysis of Individuals with Colorectal Cancer

Lower Expression of <i>CFTR</i> Is Associated with Higher Mortality in a Meta-Analysis of Individuals with Colorectal Cancer

Individuals with cystic fibrosis (CF), caused by biallelic germline mutations in the cystic fibrosis transmembrane conductance regulator (<i>CFTR)</i>, have higher risk and earlier onset of colorectal cancer (CRC). A subset of CRC patients in the non-CF population expresses low levels of...

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Bibliographic Details
Main Authors: Patricia Scott, Shuo Wang, Guillaume Onyeaghala, Nathan Pankratz, Timothy Starr, Anna E. Prizment
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cancers
Subjects:
colorectal cancer
CFTR
survival
mortality
Cox proportional hazards regression
TCGA COADREAD
Online Access:https://www.mdpi.com/2072-6694/15/3/989

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