Impact of intravenous administration of nalbuphine at different time points for postoperative analgesia and sedation in adenotonsillectomized children: a prospective, randomized controlled trial
Objective To compare the efficacy of intravenous administration of nalbuphine at different time points for postoperative analgesia and sedation in adenotonsillectomized children.Methods Patients with obstructive sleep apnea syndrome scheduled for adenotonsillectomy were randomly divided into group A...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-10-01
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| Series: | World Journal of Pediatric Surgery |
| Online Access: | https://wjps.bmj.com/content/6/4/e000662.full |
| _version_ | 1797365937643454464 |
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| author | Jinjin Huang Jing Gao Hongmin Cao Chunying Bao Haiya Tu Qixing Chen |
| author_facet | Jinjin Huang Jing Gao Hongmin Cao Chunying Bao Haiya Tu Qixing Chen |
| author_sort | Jinjin Huang |
| collection | DOAJ |
| description | Objective To compare the efficacy of intravenous administration of nalbuphine at different time points for postoperative analgesia and sedation in adenotonsillectomized children.Methods Patients with obstructive sleep apnea syndrome scheduled for adenotonsillectomy were randomly divided into group A (patients received intravenous nalbuphine 0.2 mg/kg before anesthesia induction), group B (patients received intravenous nalbuphine 0.2 mg/kg 10 min before the end of surgery), and group C (patients did not receive nalbuphine injection). The time points for measuring outcomes were before anesthesia induction (T0), extubation (T1), and 0, 15, 30, or 45 min in the postanesthesia care unit (PACU) (T2–T5, respectively).Results There were 40 patients in group A, 41 patients in group B and 39 patients in group C. Patients in group B had significantly lower FLACC (Face, Legs, Activity, Cry, Consolability) pain scores at T2–T5 than those in group C (all p<0.05). Patients in group B had higher Ramsay Sedation Score at T2–T4 than those in group C (all p<0.05). The proportion of patients who received remedial analgesia in the PACU in group A (17.5%, p=0.008) and group B (9.8%, p<0.001) was significantly lower than that in group C (46.2%).Conclusion Intravenous administration of nalbuphine 10 min before the end of adenotonsillectomy in children could decrease pain intensity and increase sedation levels during the recovery period with the reduction of remedial analgesia in the PACU.Trial registration number ChiCTR2200060118. |
| first_indexed | 2024-03-08T16:57:05Z |
| format | Article |
| id | doaj.art-a6f527ddfd354e11bacb15dfc71a29ca |
| institution | Directory Open Access Journal |
| issn | 2516-5410 |
| language | English |
| last_indexed | 2024-03-08T16:57:05Z |
| publishDate | 2023-10-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | World Journal of Pediatric Surgery |
| spelling | doaj.art-a6f527ddfd354e11bacb15dfc71a29ca2024-01-04T23:15:07ZengBMJ Publishing GroupWorld Journal of Pediatric Surgery2516-54102023-10-016410.1136/wjps-2023-000662Impact of intravenous administration of nalbuphine at different time points for postoperative analgesia and sedation in adenotonsillectomized children: a prospective, randomized controlled trialJinjin Huang0Jing Gao1Hongmin Cao2Chunying Bao3Haiya Tu4Qixing Chen5Department of Anesthesiology, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, ChinaDepartment of Anesthesiology, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, ChinaDepartment of Anesthesiology, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, ChinaDepartment of Anesthesiology, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, ChinaDepartment of Anesthesiology, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, ChinaDepartment of Clinical Research Center, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, ChinaObjective To compare the efficacy of intravenous administration of nalbuphine at different time points for postoperative analgesia and sedation in adenotonsillectomized children.Methods Patients with obstructive sleep apnea syndrome scheduled for adenotonsillectomy were randomly divided into group A (patients received intravenous nalbuphine 0.2 mg/kg before anesthesia induction), group B (patients received intravenous nalbuphine 0.2 mg/kg 10 min before the end of surgery), and group C (patients did not receive nalbuphine injection). The time points for measuring outcomes were before anesthesia induction (T0), extubation (T1), and 0, 15, 30, or 45 min in the postanesthesia care unit (PACU) (T2–T5, respectively).Results There were 40 patients in group A, 41 patients in group B and 39 patients in group C. Patients in group B had significantly lower FLACC (Face, Legs, Activity, Cry, Consolability) pain scores at T2–T5 than those in group C (all p<0.05). Patients in group B had higher Ramsay Sedation Score at T2–T4 than those in group C (all p<0.05). The proportion of patients who received remedial analgesia in the PACU in group A (17.5%, p=0.008) and group B (9.8%, p<0.001) was significantly lower than that in group C (46.2%).Conclusion Intravenous administration of nalbuphine 10 min before the end of adenotonsillectomy in children could decrease pain intensity and increase sedation levels during the recovery period with the reduction of remedial analgesia in the PACU.Trial registration number ChiCTR2200060118.https://wjps.bmj.com/content/6/4/e000662.full |
| spellingShingle | Jinjin Huang Jing Gao Hongmin Cao Chunying Bao Haiya Tu Qixing Chen Impact of intravenous administration of nalbuphine at different time points for postoperative analgesia and sedation in adenotonsillectomized children: a prospective, randomized controlled trial World Journal of Pediatric Surgery |
| title | Impact of intravenous administration of nalbuphine at different time points for postoperative analgesia and sedation in adenotonsillectomized children: a prospective, randomized controlled trial |
| title_full | Impact of intravenous administration of nalbuphine at different time points for postoperative analgesia and sedation in adenotonsillectomized children: a prospective, randomized controlled trial |
| title_fullStr | Impact of intravenous administration of nalbuphine at different time points for postoperative analgesia and sedation in adenotonsillectomized children: a prospective, randomized controlled trial |
| title_full_unstemmed | Impact of intravenous administration of nalbuphine at different time points for postoperative analgesia and sedation in adenotonsillectomized children: a prospective, randomized controlled trial |
| title_short | Impact of intravenous administration of nalbuphine at different time points for postoperative analgesia and sedation in adenotonsillectomized children: a prospective, randomized controlled trial |
| title_sort | impact of intravenous administration of nalbuphine at different time points for postoperative analgesia and sedation in adenotonsillectomized children a prospective randomized controlled trial |
| url | https://wjps.bmj.com/content/6/4/e000662.full |
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