Predictive Factors of Seizures in Patients with Organophosphate Poisoning
Background: Poisoning with organophosphate (OP) compounds is common and causes many complications, including seizure. The purpose of this study was to investigate the predictor factors of seizure in patients with organophosphate poisoning. Methods: This study was performed on patients with organoph...
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| Format: | Article |
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Isfahan University of Medical Sciences
2018-02-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/9208 |
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| author | Ahmad Yaraghi Shadi Nasr-Esfahani Nastaran Eizadi-Mood |
| author_facet | Ahmad Yaraghi Shadi Nasr-Esfahani Nastaran Eizadi-Mood |
| author_sort | Ahmad Yaraghi |
| collection | DOAJ |
| description | Background: Poisoning with organophosphate (OP) compounds is common and causes many complications, including seizure. The purpose of this study was to investigate the predictor factors of seizure in patients with organophosphate poisoning.
Methods: This study was performed on patients with organophosphate poisoning hospitalized from 2007 to 2015 in university referral hospital in Isfahan City, Iran. Patients' information including age, sex, seizure, time between ingestion and admission to hospital, vital signs, duration of connection to ventilator, blood glucose, and blood pH were evaluated. The different variables were compared between patients with and without seizure. Binary logistic regression was used for determining variables for prediction of seizure.
Findings: 209 patients with organophosphate poisoning were evaluated during the study period. Patients’ mean age was 33.1 ± 18.4 years (range: 2-90 years). Most of the patients were men (61.2%). The prevalence of seizure in patients was 5.7%, which was more common in patients with miosis (33.3% vs. 13.7%, P = 0.040). Patients with seizure required more intubation and longer periods of ventilation (5.1 ± 3.2 vs. 0.9 ± 0.4 days, P < 0.001). There was no significant difference between patients with and without seizure with respect to other variables. 27 patients died, of whom 3 patients had seizure. None of the above variables were predictive for seizure.
Conclusion: The results of this study showed that the prevalence of seizure in patients with organophosphate poisoning was 5.7%. Seizure was more common in those with miosis. Length of ventilation was more in patients with seizure. |
| first_indexed | 2024-03-12T08:26:04Z |
| format | Article |
| id | doaj.art-a6f6b57f604145ddac32669a84d84670 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T08:26:04Z |
| publishDate | 2018-02-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-a6f6b57f604145ddac32669a84d846702023-09-02T18:06:47ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2018-02-01354581738174310.22122/jims.v35i458.92082737Predictive Factors of Seizures in Patients with Organophosphate PoisoningAhmad Yaraghi0Shadi Nasr-Esfahani1Nastaran Eizadi-Mood2Professor, Isfahan Clinical Toxicology Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranStudent of Medicine, Student Research Committee, School of Medicine AND Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, IranProfessor, Isfahan Clinical Toxicology Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBackground: Poisoning with organophosphate (OP) compounds is common and causes many complications, including seizure. The purpose of this study was to investigate the predictor factors of seizure in patients with organophosphate poisoning. Methods: This study was performed on patients with organophosphate poisoning hospitalized from 2007 to 2015 in university referral hospital in Isfahan City, Iran. Patients' information including age, sex, seizure, time between ingestion and admission to hospital, vital signs, duration of connection to ventilator, blood glucose, and blood pH were evaluated. The different variables were compared between patients with and without seizure. Binary logistic regression was used for determining variables for prediction of seizure. Findings: 209 patients with organophosphate poisoning were evaluated during the study period. Patients’ mean age was 33.1 ± 18.4 years (range: 2-90 years). Most of the patients were men (61.2%). The prevalence of seizure in patients was 5.7%, which was more common in patients with miosis (33.3% vs. 13.7%, P = 0.040). Patients with seizure required more intubation and longer periods of ventilation (5.1 ± 3.2 vs. 0.9 ± 0.4 days, P < 0.001). There was no significant difference between patients with and without seizure with respect to other variables. 27 patients died, of whom 3 patients had seizure. None of the above variables were predictive for seizure. Conclusion: The results of this study showed that the prevalence of seizure in patients with organophosphate poisoning was 5.7%. Seizure was more common in those with miosis. Length of ventilation was more in patients with seizure.http://jims.mui.ac.ir/index.php/jims/article/view/9208Organophosphate insecticidePoisoningSeizureMiosisVentilation |
| spellingShingle | Ahmad Yaraghi Shadi Nasr-Esfahani Nastaran Eizadi-Mood Predictive Factors of Seizures in Patients with Organophosphate Poisoning مجله دانشکده پزشکی اصفهان Organophosphate insecticide Poisoning Seizure Miosis Ventilation |
| title | Predictive Factors of Seizures in Patients with Organophosphate Poisoning |
| title_full | Predictive Factors of Seizures in Patients with Organophosphate Poisoning |
| title_fullStr | Predictive Factors of Seizures in Patients with Organophosphate Poisoning |
| title_full_unstemmed | Predictive Factors of Seizures in Patients with Organophosphate Poisoning |
| title_short | Predictive Factors of Seizures in Patients with Organophosphate Poisoning |
| title_sort | predictive factors of seizures in patients with organophosphate poisoning |
| topic | Organophosphate insecticide Poisoning Seizure Miosis Ventilation |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/9208 |
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