Phosphorylation of p90RSK is associated with increased response to neoadjuvant chemotherapy in ER-positive breast cancer

Phosphorylation of p90RSK is associated with increased response to neoadjuvant chemotherapy in ER-positive breast cancer

<p>Abstract</p> <p>Background</p> <p>The clinical implication of Ras/Raf/ERK pathway activity in breast cancer tissue and its association with response to chemotherapy is controversial. We aimed to explore the value of p90RSK phosphorylation, a downstram molecule of the...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí:	Moon Hyeong-Gon, Yi Jae, Kim Hee, Lee Hea, Lee Kyung-Min, Yi Minju, Ahn Sookyung, Shin Hee-Chul, Ju Ji-hyun, Shin Incheol, Han Wonshik, Noh Dong-Young
Formáid:	Alt
Teanga:	English
Foilsithe / Cruthaithe:	BMC 2012-12-01
Sraith:	BMC Cancer
Ábhair:	Breast cancer P90RSK Chemotherapy Predictive marker ERK Estrogen receptor
Rochtain ar líne:	http://www.biomedcentral.com/1471-2407/12/585

Míreanna comhchosúla

RSK2 and ERα comrades-in-arms in homeostasis and transformation
de réir: Katarzyna A. Ludwik, et al.
Foilsithe / Cruthaithe: (2020-11-01)

Identifying requirements for RSK2 specific inhibitors
de réir: Eric B. Wright, et al.
Foilsithe / Cruthaithe: (2021-01-01)

Radiation therapy induces immunosenescence mediated by p90RSK
de réir: Masaki Imanishi, et al.
Foilsithe / Cruthaithe: (2022-11-01)

mTORC2 Is Involved in the Induction of RSK Phosphorylation by Serum or Nutrient Starvation
de réir: Po-Chien Chou, et al.
Foilsithe / Cruthaithe: (2020-06-01)

Artemether confers neuroprotection on cerebral ischemic injury through stimulation of the Erk1/2-P90rsk-CREB signaling pathway
de réir: Shuai Li, et al.
Foilsithe / Cruthaithe: (2021-10-01)

p90RSK pathway inhibition synergizes with cisplatin in TMEM16A overexpressing head and neck cancer
de réir: Abdulkader Yassin-Kassab, et al.
Foilsithe / Cruthaithe: (2024-02-01)

RSK Isoforms in Acute Myeloid Leukemia
de réir: Minyoung Youn, et al.
Foilsithe / Cruthaithe: (2021-06-01)

Corrigendum: p90RSK-MAGI1 Module Controls Endothelial Permeability by Post-translational Modifications of MAGI1 and Hippo Pathway
de réir: Rei J. Abe, et al.
Foilsithe / Cruthaithe: (2021-02-01)

Therapeutic targeting of p90 ribosomal S6 kinase
de réir: Eric B. Wright, et al.
Foilsithe / Cruthaithe: (2023-12-01)

Targeting the p90RSK/MDM2/p53 Pathway Is Effective in Blocking Tumors with Oncogenic Up-Regulation of the MAPK Pathway Such as Melanoma and Lung Cancer
de réir: Immacolata Maietta, et al.
Foilsithe / Cruthaithe: (2024-09-01)

Punicalagin as a novel selective aryl hydrocarbon receptor (AhR) modulator upregulates AhR expression through the PDK1/p90RSK/AP-1 pathway to promote the anti-inflammatory response and bactericidal activity of macrophages
de réir: Weihong Dai, et al.
Foilsithe / Cruthaithe: (2024-10-01)

p90RSK2, a new MLCK mediates contractility in myosin light chain kinase null smooth muscle
de réir: Jaspreet Kalra, et al.
Foilsithe / Cruthaithe: (2023-09-01)

RSK1 and RSK2 serine/threonine kinases regulate different transcription programs in cancer
de réir: Won Seok Yang, et al.
Foilsithe / Cruthaithe: (2023-01-01)

Protein phosphatase 2Cδ/Wip1 regulates phospho-p90RSK2 activity in lesional psoriatic skin
de réir: Rasmussen MK, et al.
Foilsithe / Cruthaithe: (2017-12-01)

Ginsenoside Rh1 Inhibits Angiotensin II-Induced Vascular Smooth Muscle Cell Migration and Proliferation through Suppression of the ROS-Mediated ERK1/2/p90RSK/KLF4 Signaling Pathway
de réir: Diem Thi Ngoc Huynh, et al.
Foilsithe / Cruthaithe: (2022-03-01)

Substituted pteridinones, pyrimidines, pyrrolopyrimidines, and purines as p90 ribosomal S6 protein kinase-2 (RSK2) inhibitors: Pharmacophore modeling data
de réir: Becka M. Warfield, et al.
Foilsithe / Cruthaithe: (2021-10-01)

Updating mRNA variants of the human RSK4 gene and their expression in different stressed situations
de réir: Zhenwei Qin, et al.
Foilsithe / Cruthaithe: (2024-04-01)

CD147 mediates epidermal malignant transformation through the RSK2/AP-1 pathway
de réir: Xu Zhang, et al.
Foilsithe / Cruthaithe: (2022-08-01)

Raltitrexed regulates proliferation and apoptosis of HGC-27 cells by upregulating RSK4
de réir: Cong Hu, et al.
Foilsithe / Cruthaithe: (2022-08-01)

Application of genetic algorithm - multiple linear regressions to predict the activity of RSK inhibitors
de réir: Avval Zhila Mohajeri, et al.
Foilsithe / Cruthaithe: (2015-01-01)

Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX
de réir: Jiajia Ma, et al.
Foilsithe / Cruthaithe: (2021-06-01)

RSK1 vs. RSK2 Inhibitory Activity of the Marine β-Carboline Alkaloid Manzamine A: A Biochemical, Cervical Cancer Protein Expression, and Computational Study
de réir: Alejandro M. S. Mayer, et al.
Foilsithe / Cruthaithe: (2021-09-01)

Drosophila RSK Influences the Pace of the Circadian Clock by Negative Regulation of Protein Kinase Shaggy Activity
de réir: Katherina Beck, et al.
Foilsithe / Cruthaithe: (2018-04-01)

Analgesic
de réir: Bian Juhua, et al.
Foilsithe / Cruthaithe: (2016-05-01)

RSK2 promotes melanoma cell proliferation and vemurafenib resistance via upregulating cyclin D1
de réir: Hai-Zhou Wu, et al.
Foilsithe / Cruthaithe: (2022-09-01)

Effect of RSK4 on biological characteristics of colorectal cancer
de réir: Qingqing Ye, et al.
Foilsithe / Cruthaithe: (2018-12-01)

L-plastin Ser5 phosphorylation is modulated by the PI3K/SGK pathway and promotes breast cancer cell invasiveness
de réir: Raquel A. C. Machado, et al.
Foilsithe / Cruthaithe: (2021-02-01)

RSK4 promotes the metastasis of clear cell renal cell carcinoma by activating RUNX1-mediated angiogenesis
de réir: Jing Ma, et al.
Foilsithe / Cruthaithe: (2025-12-01)

EGFR is required for FOS‐dependent bone tumor development via RSK2/CREB signaling
de réir: Markus Linder, et al.
Foilsithe / Cruthaithe: (2018-10-01)

Association Between RSK2 and Clinical Indexes of Primary Breast Cancer: A Meta-Analysis Based on mRNA Microarray Data
de réir: Kun Zheng, et al.
Foilsithe / Cruthaithe: (2021-11-01)

Ribosomal S6 kinase (RSK) plays a critical role in DNA damage response via the phosphorylation of histone lysine demethylase KDM4B
de réir: Wenwen Wu, et al.
Foilsithe / Cruthaithe: (2024-10-01)

Serine‐227 in the N‐terminal kinase domain of RSK2 is a potential therapeutic target for mantle cell lymphoma
de réir: Yayoi Matsumura‐Kimoto, et al.
Foilsithe / Cruthaithe: (2020-07-01)

The molecular mechanisms of Aloin induce gastric cancer cells apoptosis by targeting High Mobility Group Box 1
de réir: Tao H, et al.
Foilsithe / Cruthaithe: (2019-04-01)

Animal Models for Coffin-Lowry Syndrome: RSK2 and Nervous System Dysfunction
de réir: Matthias Fischer, et al.
Foilsithe / Cruthaithe: (2018-05-01)

Loss of the Coffin-Lowry syndrome-associated gene RSK2 alters ERK activity, synaptic function and axonal transport in Drosophila motoneurons
de réir: Katherina Beck, et al.
Foilsithe / Cruthaithe: (2015-11-01)

Correlation of TRAF4 and RSK4 Protein Expression Levels in Gastric Cancer Tissues with Recurrence After Laparoscopic Radical Resection
de réir: WU Ling, et al.
Foilsithe / Cruthaithe: (2023-02-01)

Expression of RSK4, CD44 and MMP-9 is upregulated and positively correlated in metastatic ccRCC
de réir: Jing Ma, et al.
Foilsithe / Cruthaithe: (2020-03-01)

Marine-Based Candidates as Potential RSK1 Inhibitors: A Computational Study
de réir: Mousa AlTarabeen, et al.
Foilsithe / Cruthaithe: (2022-12-01)

Combination Kinase Inhibitor Treatment Suppresses Rift Valley Fever Virus Replication
de réir: Todd M. Bell, et al.
Foilsithe / Cruthaithe: (2018-04-01)

DockCADD: A streamlined in silico pipeline for the identification of potent ribosomal S6 Kinase 2 (RSK2) inhibitors
de réir: El Mehdi Karim, et al.
Foilsithe / Cruthaithe: (2025-03-01)