Angiotensin-II-induced reactive oxygen species along the SFO-PVN-RVLM pathway: implications in neurogenic hypertension
Neurogenic hypertension has been the subject of extensive research worldwide. This review is based on the premise that some forms of neurogenic hypertension are caused in part by the formation of angiotensin-II (Ang-II)-induced reactive oxygen species along the subfornical organ-paraventricular nucl...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2011-09-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900007&lng=en&tlng=en |
| _version_ | 1819076425568747520 |
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| author | V.A. Braga I.A. Medeiros T.P. Ribeiro M.S. França-Silva M.S. Botelho-Ono D.D. Guimarães |
| author_facet | V.A. Braga I.A. Medeiros T.P. Ribeiro M.S. França-Silva M.S. Botelho-Ono D.D. Guimarães |
| author_sort | V.A. Braga |
| collection | DOAJ |
| description | Neurogenic hypertension has been the subject of extensive research worldwide. This review is based on the premise that some forms of neurogenic hypertension are caused in part by the formation of angiotensin-II (Ang-II)-induced reactive oxygen species along the subfornical organ-paraventricular nucleus of the hypothalamus-rostral ventrolateral medulla pathway (SFO-PVN-RVLM pathway). We will discuss the recent contribution of our laboratory and others regarding the mechanisms by which neurons in the SFO (an important circumventricular organ) are activated by Ang-II, how the SFO communicates with two other important areas involved in sympathetic activity regulation (PVN and RVLM) and how Ang-II-induced reactive oxygen species participate along the SFO-PVN-RVLM pathway in the pathogenesis of neurogenic hypertension. |
| first_indexed | 2024-12-21T18:41:06Z |
| format | Article |
| id | doaj.art-a6f83bf08877400592797614154f10df |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-12-21T18:41:06Z |
| publishDate | 2011-09-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-a6f83bf08877400592797614154f10df2022-12-21T18:54:00ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X2011-09-0144987187610.1590/S0100-879X2011000900007S0100-879X2011000900007Angiotensin-II-induced reactive oxygen species along the SFO-PVN-RVLM pathway: implications in neurogenic hypertensionV.A. Braga0I.A. Medeiros1T.P. Ribeiro2M.S. França-Silva3M.S. Botelho-Ono4D.D. Guimarães5Universidade Federal da ParaíbaUniversidade Federal da ParaíbaUniversidade Federal da ParaíbaUniversidade Federal da ParaíbaUniversidade Federal da ParaíbaUniversidade Federal da ParaíbaNeurogenic hypertension has been the subject of extensive research worldwide. This review is based on the premise that some forms of neurogenic hypertension are caused in part by the formation of angiotensin-II (Ang-II)-induced reactive oxygen species along the subfornical organ-paraventricular nucleus of the hypothalamus-rostral ventrolateral medulla pathway (SFO-PVN-RVLM pathway). We will discuss the recent contribution of our laboratory and others regarding the mechanisms by which neurons in the SFO (an important circumventricular organ) are activated by Ang-II, how the SFO communicates with two other important areas involved in sympathetic activity regulation (PVN and RVLM) and how Ang-II-induced reactive oxygen species participate along the SFO-PVN-RVLM pathway in the pathogenesis of neurogenic hypertension.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900007&lng=en&tlng=enSuperoxideSympatheticAngiotensinSubfornical organParaventricular nucleus of the hypothalamusRostral ventrolateral medulla |
| spellingShingle | V.A. Braga I.A. Medeiros T.P. Ribeiro M.S. França-Silva M.S. Botelho-Ono D.D. Guimarães Angiotensin-II-induced reactive oxygen species along the SFO-PVN-RVLM pathway: implications in neurogenic hypertension Brazilian Journal of Medical and Biological Research Superoxide Sympathetic Angiotensin Subfornical organ Paraventricular nucleus of the hypothalamus Rostral ventrolateral medulla |
| title | Angiotensin-II-induced reactive oxygen species along the SFO-PVN-RVLM pathway: implications in neurogenic hypertension |
| title_full | Angiotensin-II-induced reactive oxygen species along the SFO-PVN-RVLM pathway: implications in neurogenic hypertension |
| title_fullStr | Angiotensin-II-induced reactive oxygen species along the SFO-PVN-RVLM pathway: implications in neurogenic hypertension |
| title_full_unstemmed | Angiotensin-II-induced reactive oxygen species along the SFO-PVN-RVLM pathway: implications in neurogenic hypertension |
| title_short | Angiotensin-II-induced reactive oxygen species along the SFO-PVN-RVLM pathway: implications in neurogenic hypertension |
| title_sort | angiotensin ii induced reactive oxygen species along the sfo pvn rvlm pathway implications in neurogenic hypertension |
| topic | Superoxide Sympathetic Angiotensin Subfornical organ Paraventricular nucleus of the hypothalamus Rostral ventrolateral medulla |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900007&lng=en&tlng=en |
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