The Combination of Uric Acid and Hemoglobin Levels Predicts the Incident Risk of Ischemic Heart Disease More Than Uric Acid Alone in Non-Diabetic Koreans: A Longitudinal Study Using National Health Insurance Data
Uric acid has been related to cardiovascular disease (CVD). Recently, slightly elevated hemoglobin (Hb) was also shown to be associated with CVD. We retrospectively investigated the joint effect of uric acid and elevated Hb by comparing normal-range uric acid alone on incident ischemic heart disease...
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MDPI AG
2023-12-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/14/1/7 |
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| author | Sung-Bum Lee Hui-Jeong Lee Ha Eun Ryu Byoungjin Park Dong-Hyuk Jung |
| author_facet | Sung-Bum Lee Hui-Jeong Lee Ha Eun Ryu Byoungjin Park Dong-Hyuk Jung |
| author_sort | Sung-Bum Lee |
| collection | DOAJ |
| description | Uric acid has been related to cardiovascular disease (CVD). Recently, slightly elevated hemoglobin (Hb) was also shown to be associated with CVD. We retrospectively investigated the joint effect of uric acid and elevated Hb by comparing normal-range uric acid alone on incident ischemic heart disease (IHD) risk in a large cohort of non-diabetic Korean adults using National Health Insurance data. We assessed 16,786 participants without diabetes (8595 men and 8191 women) using extensive cohort data. High Hb was defined as ≥16.4 g/dL in men and 13.8 g/dL in women (>75th percentile). We analyzed the data using two different methods. First, the participants were divided into quartiles according to uric acid levels. Second, subjects were also divided into quartiles: reference (group 1), high uric acid and normal Hb (group 2), normal uric acid and high Hb (group 3), and normal uric acid and high Hb (group 4). We evaluated hazard ratios (HRs) with 95% confidence intervals (CIs) for IHD using multivariate Cox regression analysis over a 50-month follow-up. During the follow-up, 345 (1.9%) participants developed IHD. In the analysis using both uric acid and Hb, compared with the reference group, the HRs for IHD were 1.37 (95% CI, 1.01–1.86) in the second group, 1.63 (95% CI, 1.21–2.21) in the third group, and 1.86 (95% CI, 1.30–2.67) in the fourth group after adjusting for IHD risk factors. Subsequently, patients with high uric acid are more likely to develop incident IHD than control patients. Moreover, we confirmed the joint effects of high uric acid and high hemoglobin on incident IHD. Awareness of these interactions is essential for clinicians. Risk factor management and screening for IHD are part of the routine management of patients with high uric acid and Hb. |
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| language | English |
| last_indexed | 2024-03-08T10:45:31Z |
| publishDate | 2023-12-01 |
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| series | Journal of Personalized Medicine |
| spelling | doaj.art-a6f8e29a441149db9bafda790eee25712024-01-26T17:19:15ZengMDPI AGJournal of Personalized Medicine2075-44262023-12-01141710.3390/jpm14010007The Combination of Uric Acid and Hemoglobin Levels Predicts the Incident Risk of Ischemic Heart Disease More Than Uric Acid Alone in Non-Diabetic Koreans: A Longitudinal Study Using National Health Insurance DataSung-Bum Lee0Hui-Jeong Lee1Ha Eun Ryu2Byoungjin Park3Dong-Hyuk Jung4Department of Family Medicine, Soonchunhyang University Bucheon Hospital, Bucheon 22972, Republic of KoreaDepartment of Family Medicine, Soonchunhyang University Bucheon Hospital, Bucheon 22972, Republic of KoreaDepartment of Family Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of KoreaDepartment of Family Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of KoreaDepartment of Family Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of KoreaUric acid has been related to cardiovascular disease (CVD). Recently, slightly elevated hemoglobin (Hb) was also shown to be associated with CVD. We retrospectively investigated the joint effect of uric acid and elevated Hb by comparing normal-range uric acid alone on incident ischemic heart disease (IHD) risk in a large cohort of non-diabetic Korean adults using National Health Insurance data. We assessed 16,786 participants without diabetes (8595 men and 8191 women) using extensive cohort data. High Hb was defined as ≥16.4 g/dL in men and 13.8 g/dL in women (>75th percentile). We analyzed the data using two different methods. First, the participants were divided into quartiles according to uric acid levels. Second, subjects were also divided into quartiles: reference (group 1), high uric acid and normal Hb (group 2), normal uric acid and high Hb (group 3), and normal uric acid and high Hb (group 4). We evaluated hazard ratios (HRs) with 95% confidence intervals (CIs) for IHD using multivariate Cox regression analysis over a 50-month follow-up. During the follow-up, 345 (1.9%) participants developed IHD. In the analysis using both uric acid and Hb, compared with the reference group, the HRs for IHD were 1.37 (95% CI, 1.01–1.86) in the second group, 1.63 (95% CI, 1.21–2.21) in the third group, and 1.86 (95% CI, 1.30–2.67) in the fourth group after adjusting for IHD risk factors. Subsequently, patients with high uric acid are more likely to develop incident IHD than control patients. Moreover, we confirmed the joint effects of high uric acid and high hemoglobin on incident IHD. Awareness of these interactions is essential for clinicians. Risk factor management and screening for IHD are part of the routine management of patients with high uric acid and Hb.https://www.mdpi.com/2075-4426/14/1/7uric acidhemoglobinischemic heart diseasenational health insurance dataKorea |
| spellingShingle | Sung-Bum Lee Hui-Jeong Lee Ha Eun Ryu Byoungjin Park Dong-Hyuk Jung The Combination of Uric Acid and Hemoglobin Levels Predicts the Incident Risk of Ischemic Heart Disease More Than Uric Acid Alone in Non-Diabetic Koreans: A Longitudinal Study Using National Health Insurance Data Journal of Personalized Medicine uric acid hemoglobin ischemic heart disease national health insurance data Korea |
| title | The Combination of Uric Acid and Hemoglobin Levels Predicts the Incident Risk of Ischemic Heart Disease More Than Uric Acid Alone in Non-Diabetic Koreans: A Longitudinal Study Using National Health Insurance Data |
| title_full | The Combination of Uric Acid and Hemoglobin Levels Predicts the Incident Risk of Ischemic Heart Disease More Than Uric Acid Alone in Non-Diabetic Koreans: A Longitudinal Study Using National Health Insurance Data |
| title_fullStr | The Combination of Uric Acid and Hemoglobin Levels Predicts the Incident Risk of Ischemic Heart Disease More Than Uric Acid Alone in Non-Diabetic Koreans: A Longitudinal Study Using National Health Insurance Data |
| title_full_unstemmed | The Combination of Uric Acid and Hemoglobin Levels Predicts the Incident Risk of Ischemic Heart Disease More Than Uric Acid Alone in Non-Diabetic Koreans: A Longitudinal Study Using National Health Insurance Data |
| title_short | The Combination of Uric Acid and Hemoglobin Levels Predicts the Incident Risk of Ischemic Heart Disease More Than Uric Acid Alone in Non-Diabetic Koreans: A Longitudinal Study Using National Health Insurance Data |
| title_sort | combination of uric acid and hemoglobin levels predicts the incident risk of ischemic heart disease more than uric acid alone in non diabetic koreans a longitudinal study using national health insurance data |
| topic | uric acid hemoglobin ischemic heart disease national health insurance data Korea |
| url | https://www.mdpi.com/2075-4426/14/1/7 |
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