Engraftment of allogeneic iPS cell-derived cartilage organoid in a primate model of articular cartilage defect
Allogeneic iPSC-derived cartilage organoids survive and integrate with surrounding native cartilage without immune reactions in a primate model of chondral defects in the knee joints, being remodeled and functioning as articular cartilage.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36408-0 |
| _version_ | 1797864300132433920 |
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| author | Kengo Abe Akihiro Yamashita Miho Morioka Nanao Horike Yoshiaki Takei Saeko Koyamatsu Keisuke Okita Shuichi Matsuda Noriyuki Tsumaki |
| author_facet | Kengo Abe Akihiro Yamashita Miho Morioka Nanao Horike Yoshiaki Takei Saeko Koyamatsu Keisuke Okita Shuichi Matsuda Noriyuki Tsumaki |
| author_sort | Kengo Abe |
| collection | DOAJ |
| description | Allogeneic iPSC-derived cartilage organoids survive and integrate with surrounding native cartilage without immune reactions in a primate model of chondral defects in the knee joints, being remodeled and functioning as articular cartilage. |
| first_indexed | 2024-04-09T22:49:38Z |
| format | Article |
| id | doaj.art-a6f90fa076c44df0877754a3e2a63549 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:49:38Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a6f90fa076c44df0877754a3e2a635492023-03-22T11:41:44ZengNature PortfolioNature Communications2041-17232023-02-0114111610.1038/s41467-023-36408-0Engraftment of allogeneic iPS cell-derived cartilage organoid in a primate model of articular cartilage defectKengo Abe0Akihiro Yamashita1Miho Morioka2Nanao Horike3Yoshiaki Takei4Saeko Koyamatsu5Keisuke Okita6Shuichi Matsuda7Noriyuki Tsumaki8Department of Tissue Biochemistry, Graduate School of Medicine and Frontier Biosciences, Osaka UniversityDepartment of Tissue Biochemistry, Graduate School of Medicine and Frontier Biosciences, Osaka UniversityDepartment of Tissue Biochemistry, Graduate School of Medicine and Frontier Biosciences, Osaka UniversityDepartment of Tissue Biochemistry, Graduate School of Medicine and Frontier Biosciences, Osaka UniversityDepartment of Clinical Application, Center for iPS Cell Research and Application, Kyoto UniversityDepartment of Tissue Biochemistry, Graduate School of Medicine and Frontier Biosciences, Osaka UniversityDepartment of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto UniversityDepartment of Orthopaedic Surgery, Graduate School of Medicine, Kyoto UniversityDepartment of Tissue Biochemistry, Graduate School of Medicine and Frontier Biosciences, Osaka UniversityAllogeneic iPSC-derived cartilage organoids survive and integrate with surrounding native cartilage without immune reactions in a primate model of chondral defects in the knee joints, being remodeled and functioning as articular cartilage.https://doi.org/10.1038/s41467-023-36408-0 |
| spellingShingle | Kengo Abe Akihiro Yamashita Miho Morioka Nanao Horike Yoshiaki Takei Saeko Koyamatsu Keisuke Okita Shuichi Matsuda Noriyuki Tsumaki Engraftment of allogeneic iPS cell-derived cartilage organoid in a primate model of articular cartilage defect Nature Communications |
| title | Engraftment of allogeneic iPS cell-derived cartilage organoid in a primate model of articular cartilage defect |
| title_full | Engraftment of allogeneic iPS cell-derived cartilage organoid in a primate model of articular cartilage defect |
| title_fullStr | Engraftment of allogeneic iPS cell-derived cartilage organoid in a primate model of articular cartilage defect |
| title_full_unstemmed | Engraftment of allogeneic iPS cell-derived cartilage organoid in a primate model of articular cartilage defect |
| title_short | Engraftment of allogeneic iPS cell-derived cartilage organoid in a primate model of articular cartilage defect |
| title_sort | engraftment of allogeneic ips cell derived cartilage organoid in a primate model of articular cartilage defect |
| url | https://doi.org/10.1038/s41467-023-36408-0 |
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