Elevated RANTES levels are associated with increased risk of cerebral atherosclerotic stenosis
Abstract Background Cerebral atherosclerotic stenosis (CAS) is a significant factor in the development of acute ischemic stroke (AIS). Previous studies have reported that cytokines are involved in atherosclerotic diseases, although the relationship between serum levels of the chemokine RANTES (regul...
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-023-03079-9 |
| _version_ | 1811175828083441664 |
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| author | Yinping Guo Qianqian Kong Yi Zhang Jing Zhao Zhiyuan Yu Dan He Hao Huang Xiang Luo |
| author_facet | Yinping Guo Qianqian Kong Yi Zhang Jing Zhao Zhiyuan Yu Dan He Hao Huang Xiang Luo |
| author_sort | Yinping Guo |
| collection | DOAJ |
| description | Abstract Background Cerebral atherosclerotic stenosis (CAS) is a significant factor in the development of acute ischemic stroke (AIS). Previous studies have reported that cytokines are involved in atherosclerotic diseases, although the relationship between serum levels of the chemokine RANTES (regulated on activation, normal T-cell expressed and secreted) and the presence of CAS remains unclear. Methods In total, 127 participants (65 non-AIS controls and 62 patients with AIS) were involved in this study. CAS was defined as the presence of ≥ 50% stenosis in major intracranial or extracranial artery by a Digital Substraction Angiography (DSA) examination, and we classified all participants into four groups according to stroke and CAS status. Serum concentrations of 8 cytokines, including RANTES, were measured by the Human ProcartaPlex Multiplex Immunoassay Kit. Results Seventy-eight participants (61.41%) had CAS, of which 39 cases with AIS and 39 case with non-AIS. Patients with CAS had higher RANTES levels compared to non-CAS patients in both the non-AIS group (10.54 ± 0.80 vs. 13.20 ± 0.71, p = 0.016) and stroke group (11.96 ± 0.87 vs. 15.03 ± 0.75, p = 0.011), and multivariate logistic regression analysis showed that the RANTES level is independently associated with CAS in both the non-AIS group (adjusted odds ratio (OR), 1.07; 95% CI, 1.02–1.12, P = 0.004) and stroke group (adjusted OR, 1.32; 95% CI, 1.10–1.58, P = 0.003). Conclusion Patients with CAS have higher levels of serum RANTES than non-CAS patients regardless of stroke status suggesting that RANTES may play an important role in the formation of CAS. |
| first_indexed | 2024-04-10T19:42:15Z |
| format | Article |
| id | doaj.art-a6fa1f4a0bb848d8bf94bbdfa1745a7a |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-04-10T19:42:15Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-a6fa1f4a0bb848d8bf94bbdfa1745a7a2023-01-29T12:15:34ZengBMCBMC Neurology1471-23772023-01-012311610.1186/s12883-023-03079-9Elevated RANTES levels are associated with increased risk of cerebral atherosclerotic stenosisYinping Guo0Qianqian Kong1Yi Zhang2Jing Zhao3Zhiyuan Yu4Dan He5Hao Huang6Xiang Luo7Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-Sen UniversityDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Background Cerebral atherosclerotic stenosis (CAS) is a significant factor in the development of acute ischemic stroke (AIS). Previous studies have reported that cytokines are involved in atherosclerotic diseases, although the relationship between serum levels of the chemokine RANTES (regulated on activation, normal T-cell expressed and secreted) and the presence of CAS remains unclear. Methods In total, 127 participants (65 non-AIS controls and 62 patients with AIS) were involved in this study. CAS was defined as the presence of ≥ 50% stenosis in major intracranial or extracranial artery by a Digital Substraction Angiography (DSA) examination, and we classified all participants into four groups according to stroke and CAS status. Serum concentrations of 8 cytokines, including RANTES, were measured by the Human ProcartaPlex Multiplex Immunoassay Kit. Results Seventy-eight participants (61.41%) had CAS, of which 39 cases with AIS and 39 case with non-AIS. Patients with CAS had higher RANTES levels compared to non-CAS patients in both the non-AIS group (10.54 ± 0.80 vs. 13.20 ± 0.71, p = 0.016) and stroke group (11.96 ± 0.87 vs. 15.03 ± 0.75, p = 0.011), and multivariate logistic regression analysis showed that the RANTES level is independently associated with CAS in both the non-AIS group (adjusted odds ratio (OR), 1.07; 95% CI, 1.02–1.12, P = 0.004) and stroke group (adjusted OR, 1.32; 95% CI, 1.10–1.58, P = 0.003). Conclusion Patients with CAS have higher levels of serum RANTES than non-CAS patients regardless of stroke status suggesting that RANTES may play an important role in the formation of CAS.https://doi.org/10.1186/s12883-023-03079-9Cerebral atherosclerotic stenosis (CAS)CytokinesRANTES |
| spellingShingle | Yinping Guo Qianqian Kong Yi Zhang Jing Zhao Zhiyuan Yu Dan He Hao Huang Xiang Luo Elevated RANTES levels are associated with increased risk of cerebral atherosclerotic stenosis BMC Neurology Cerebral atherosclerotic stenosis (CAS) Cytokines RANTES |
| title | Elevated RANTES levels are associated with increased risk of cerebral atherosclerotic stenosis |
| title_full | Elevated RANTES levels are associated with increased risk of cerebral atherosclerotic stenosis |
| title_fullStr | Elevated RANTES levels are associated with increased risk of cerebral atherosclerotic stenosis |
| title_full_unstemmed | Elevated RANTES levels are associated with increased risk of cerebral atherosclerotic stenosis |
| title_short | Elevated RANTES levels are associated with increased risk of cerebral atherosclerotic stenosis |
| title_sort | elevated rantes levels are associated with increased risk of cerebral atherosclerotic stenosis |
| topic | Cerebral atherosclerotic stenosis (CAS) Cytokines RANTES |
| url | https://doi.org/10.1186/s12883-023-03079-9 |
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