MECHANISMS OF RESISTANCE TO IMMUNOSUPPRESSIVE THERAPY IN PATIENTS WITH NEPHROTIC SYNDROME
The present article provides a modern look at the main mechanisms of resistance to immunosuppressive therapy in patients with nephrotic syndrome. The urgency of the problem is because, in most cases, the molecular basis of steroid-resistant nephrotic syndrome is not known, which has now led to the s...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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Ltd. “The National Academy of Pediatric Science and Innovation”
2017-09-01
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| Series: | Rossijskij Vestnik Perinatologii i Pediatrii |
| Subjects: | |
| Online Access: | https://www.ped-perinatology.ru/jour/article/view/521 |
| _version_ | 1797875256905433088 |
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| author | S. L. Morozov V. V. Dlin A. R. Sadykov A. S. Voronkova V. S. Sukhorukov |
| author_facet | S. L. Morozov V. V. Dlin A. R. Sadykov A. S. Voronkova V. S. Sukhorukov |
| author_sort | S. L. Morozov |
| collection | DOAJ |
| description | The present article provides a modern look at the main mechanisms of resistance to immunosuppressive therapy in patients with nephrotic syndrome. The urgency of the problem is because, in most cases, the molecular basis of steroid-resistant nephrotic syndrome is not known, which has now led to the study of the pharmacokinetic, dynamic and genetic aspects of immunosuppressive drugs used to treat nephrotic syndrome, as well as the possibility of genotyping before treatment. The article deals with mechanisms and causes of resistance to the main immunosuppressive drugs used to treat nephrotic syndrome, which fully reflects the need for further study of pharamcogenomics and pharmacokinetics of this disease. We also consider the possibility of genotyping before treatment, which in the long term will allow us to take into account the patient's genotypic characteristics for the purpose of prescribing optimal regimens for immunosuppressive therapy and for carrying out a personalized therapy for nephrotic syndrome. |
| first_indexed | 2024-04-10T01:44:46Z |
| format | Article |
| id | doaj.art-a6fa99db35c14943b66ad7a8b725bad4 |
| institution | Directory Open Access Journal |
| issn | 1027-4065 2500-2228 |
| language | Russian |
| last_indexed | 2024-04-10T01:44:46Z |
| publishDate | 2017-09-01 |
| publisher | Ltd. “The National Academy of Pediatric Science and Innovation” |
| record_format | Article |
| series | Rossijskij Vestnik Perinatologii i Pediatrii |
| spelling | doaj.art-a6fa99db35c14943b66ad7a8b725bad42023-03-13T09:12:43ZrusLtd. “The National Academy of Pediatric Science and Innovation”Rossijskij Vestnik Perinatologii i Pediatrii1027-40652500-22282017-09-01624192410.21508/1027-4065-2017-62-4-19-24467MECHANISMS OF RESISTANCE TO IMMUNOSUPPRESSIVE THERAPY IN PATIENTS WITH NEPHROTIC SYNDROMES. L. Morozov0V. V. Dlin1A. R. Sadykov2A. S. Voronkova3V. S. Sukhorukov4ОСП «Научно-исследовательский клинический институт педиатрии им. академика Ю.Е. Вельтищева»ОСП «Научно-исследовательский клинический институт педиатрии им. академика Ю.Е. Вельтищева»ОСП «Научно-исследовательский клинический институт педиатрии им. академика Ю.Е. Вельтищева»ФГБОУ ВО РНИМУ им. Н.И. ПироговаОСП «Научно-исследовательский клинический институт педиатрии им. академика Ю.Е. Вельтищева»The present article provides a modern look at the main mechanisms of resistance to immunosuppressive therapy in patients with nephrotic syndrome. The urgency of the problem is because, in most cases, the molecular basis of steroid-resistant nephrotic syndrome is not known, which has now led to the study of the pharmacokinetic, dynamic and genetic aspects of immunosuppressive drugs used to treat nephrotic syndrome, as well as the possibility of genotyping before treatment. The article deals with mechanisms and causes of resistance to the main immunosuppressive drugs used to treat nephrotic syndrome, which fully reflects the need for further study of pharamcogenomics and pharmacokinetics of this disease. We also consider the possibility of genotyping before treatment, which in the long term will allow us to take into account the patient's genotypic characteristics for the purpose of prescribing optimal regimens for immunosuppressive therapy and for carrying out a personalized therapy for nephrotic syndrome.https://www.ped-perinatology.ru/jour/article/view/521детимолекулярная нефропатологиянефротический синдромпочкиднкрнксеквенирование ngsперсонализированная терапиятакролимусциклоспоринпреднизолон |
| spellingShingle | S. L. Morozov V. V. Dlin A. R. Sadykov A. S. Voronkova V. S. Sukhorukov MECHANISMS OF RESISTANCE TO IMMUNOSUPPRESSIVE THERAPY IN PATIENTS WITH NEPHROTIC SYNDROME Rossijskij Vestnik Perinatologii i Pediatrii дети молекулярная нефропатология нефротический синдром почки днк рнк секвенирование ngs персонализированная терапия такролимус циклоспорин преднизолон |
| title | MECHANISMS OF RESISTANCE TO IMMUNOSUPPRESSIVE THERAPY IN PATIENTS WITH NEPHROTIC SYNDROME |
| title_full | MECHANISMS OF RESISTANCE TO IMMUNOSUPPRESSIVE THERAPY IN PATIENTS WITH NEPHROTIC SYNDROME |
| title_fullStr | MECHANISMS OF RESISTANCE TO IMMUNOSUPPRESSIVE THERAPY IN PATIENTS WITH NEPHROTIC SYNDROME |
| title_full_unstemmed | MECHANISMS OF RESISTANCE TO IMMUNOSUPPRESSIVE THERAPY IN PATIENTS WITH NEPHROTIC SYNDROME |
| title_short | MECHANISMS OF RESISTANCE TO IMMUNOSUPPRESSIVE THERAPY IN PATIENTS WITH NEPHROTIC SYNDROME |
| title_sort | mechanisms of resistance to immunosuppressive therapy in patients with nephrotic syndrome |
| topic | дети молекулярная нефропатология нефротический синдром почки днк рнк секвенирование ngs персонализированная терапия такролимус циклоспорин преднизолон |
| url | https://www.ped-perinatology.ru/jour/article/view/521 |
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