Site-specific cancer risk in patients with type 2 diabetes: a nationwide population-based cohort study in Korea
Background/Aims We aimed to evaluate site-specific cancer risk in diabetic patients and to investigate causal and temporal relationships by analyzing organ-specific cancer risk according to the duration of diabetes. Methods Using a database provided by the Korean National Health Insurance Service, w...
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| Format: | Article |
| Language: | English |
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The Korean Association of Internal Medicine
2020-05-01
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| Series: | The Korean Journal of Internal Medicine |
| Subjects: | |
| Online Access: | http://www.kjim.org/upload/pdf/kjim-2017-402.pdf |
| _version_ | 1818726377383264256 |
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| author | Suk Kyeong Kim Ju-Young Jang Dong-Lim Kim Young A Rhyu Suh Eun Lee Seung-Hyun Ko Kyungdo Han Kee-Ho Song on behalf of the Task Force Team for Diabetes Fact Sheet of the Korean Diabetes Association |
| author_facet | Suk Kyeong Kim Ju-Young Jang Dong-Lim Kim Young A Rhyu Suh Eun Lee Seung-Hyun Ko Kyungdo Han Kee-Ho Song on behalf of the Task Force Team for Diabetes Fact Sheet of the Korean Diabetes Association |
| author_sort | Suk Kyeong Kim |
| collection | DOAJ |
| description | Background/Aims We aimed to evaluate site-specific cancer risk in diabetic patients and to investigate causal and temporal relationships by analyzing organ-specific cancer risk according to the duration of diabetes. Methods Using a database provided by the Korean National Health Insurance Service, we conducted a retrospective, population-based cohort study of adults aged ≥ 30 years from January 2005 to December 2013. To verify the possibility of detection bias or reverse causation, we compared hazard ratios (HRs) for each cancer according to the following duration of diabetes: less than 6 months, 6 months to 3 years, and more than 3 years. Results The incidence of overall cancer per 1,000 person-years was higher in patients with diabetes than in those without diabetes (20.36 vs. 10.83). The overall cancer risk according to the duration of diabetes was the highest within the first 6 months after diagnosis (HR, 2.03; 95% confidence interval [CI], 1.99 to 2.07), and the HR decreased with the duration of diabetes, ranging from 1.19 (95% CI, 1.18 to 1.21) between 6 months and 3 years to 1.12 (95% CI, 1.11 to 1.13) after 3 years. Both overall cancer risk and HR remained significantly higher in patients with diabetes than in those without diabetes. The risk for prostate cancer was higher in men with diabetes than in those without diabetes (HR, 1.12; 95% CI, 1.10 to 1.14). In women, the risk for endometrial cancer was significantly higher in patients with diabetes than in those without diabetes throughout the duration of diabetes. Conclusions The risk for stomach, colorectum, liver, pancreas, and kidney cancer appeared to be higher in patients with diabetes than in those without diabetes regardless of the sex or duration of diabetes. |
| first_indexed | 2024-12-17T21:57:14Z |
| format | Article |
| id | doaj.art-a6fb246081574fe7be80097becb730c1 |
| institution | Directory Open Access Journal |
| issn | 1226-3303 2005-6648 |
| language | English |
| last_indexed | 2024-12-17T21:57:14Z |
| publishDate | 2020-05-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj.art-a6fb246081574fe7be80097becb730c12022-12-21T21:31:04ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482020-05-0135364165110.3904/kjim.2017.402170110Site-specific cancer risk in patients with type 2 diabetes: a nationwide population-based cohort study in KoreaSuk Kyeong Kim0Ju-Young Jang1Dong-Lim Kim2Young A Rhyu3Suh Eun Lee4Seung-Hyun Ko5Kyungdo Han6Kee-Ho Song7on behalf of the Task Force Team for Diabetes Fact Sheet of the Korean Diabetes Association Division of Endocrinology and Metabolism, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Konkuk University Medical Center, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Konkuk University Medical Center, Seoul, Korea Graduate School of Medicine, Konkuk University, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea Department of Biostatistic, The Catholic University of Korea, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, KoreaBackground/Aims We aimed to evaluate site-specific cancer risk in diabetic patients and to investigate causal and temporal relationships by analyzing organ-specific cancer risk according to the duration of diabetes. Methods Using a database provided by the Korean National Health Insurance Service, we conducted a retrospective, population-based cohort study of adults aged ≥ 30 years from January 2005 to December 2013. To verify the possibility of detection bias or reverse causation, we compared hazard ratios (HRs) for each cancer according to the following duration of diabetes: less than 6 months, 6 months to 3 years, and more than 3 years. Results The incidence of overall cancer per 1,000 person-years was higher in patients with diabetes than in those without diabetes (20.36 vs. 10.83). The overall cancer risk according to the duration of diabetes was the highest within the first 6 months after diagnosis (HR, 2.03; 95% confidence interval [CI], 1.99 to 2.07), and the HR decreased with the duration of diabetes, ranging from 1.19 (95% CI, 1.18 to 1.21) between 6 months and 3 years to 1.12 (95% CI, 1.11 to 1.13) after 3 years. Both overall cancer risk and HR remained significantly higher in patients with diabetes than in those without diabetes. The risk for prostate cancer was higher in men with diabetes than in those without diabetes (HR, 1.12; 95% CI, 1.10 to 1.14). In women, the risk for endometrial cancer was significantly higher in patients with diabetes than in those without diabetes throughout the duration of diabetes. Conclusions The risk for stomach, colorectum, liver, pancreas, and kidney cancer appeared to be higher in patients with diabetes than in those without diabetes regardless of the sex or duration of diabetes.http://www.kjim.org/upload/pdf/kjim-2017-402.pdfdiabetesneoplasmskorean national health insurance service system |
| spellingShingle | Suk Kyeong Kim Ju-Young Jang Dong-Lim Kim Young A Rhyu Suh Eun Lee Seung-Hyun Ko Kyungdo Han Kee-Ho Song on behalf of the Task Force Team for Diabetes Fact Sheet of the Korean Diabetes Association Site-specific cancer risk in patients with type 2 diabetes: a nationwide population-based cohort study in Korea The Korean Journal of Internal Medicine diabetes neoplasms korean national health insurance service system |
| title | Site-specific cancer risk in patients with type 2 diabetes: a nationwide population-based cohort study in Korea |
| title_full | Site-specific cancer risk in patients with type 2 diabetes: a nationwide population-based cohort study in Korea |
| title_fullStr | Site-specific cancer risk in patients with type 2 diabetes: a nationwide population-based cohort study in Korea |
| title_full_unstemmed | Site-specific cancer risk in patients with type 2 diabetes: a nationwide population-based cohort study in Korea |
| title_short | Site-specific cancer risk in patients with type 2 diabetes: a nationwide population-based cohort study in Korea |
| title_sort | site specific cancer risk in patients with type 2 diabetes a nationwide population based cohort study in korea |
| topic | diabetes neoplasms korean national health insurance service system |
| url | http://www.kjim.org/upload/pdf/kjim-2017-402.pdf |
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