Neonatal Restriction of Tactile Inputs Leads to Long-Lasting Impairments of Cross-Modal Processing.

Optimal behavior relies on the combination of inputs from multiple senses through complex interactions within neocortical networks. The ontogeny of this multisensory interplay is still unknown. Here, we identify critical factors that control the development of visual-tactile processing by combining...

Full description

Bibliographic Details
Main Authors: Kay Sieben, Malte Bieler, Brigitte Röder, Ileana L Hanganu-Opatz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC4658190?pdf=render
_version_ 1818435660342624256
author Kay Sieben
Malte Bieler
Brigitte Röder
Ileana L Hanganu-Opatz
author_facet Kay Sieben
Malte Bieler
Brigitte Röder
Ileana L Hanganu-Opatz
author_sort Kay Sieben
collection DOAJ
description Optimal behavior relies on the combination of inputs from multiple senses through complex interactions within neocortical networks. The ontogeny of this multisensory interplay is still unknown. Here, we identify critical factors that control the development of visual-tactile processing by combining in vivo electrophysiology with anatomical/functional assessment of cortico-cortical communication and behavioral investigation of pigmented rats. We demonstrate that the transient reduction of unimodal (tactile) inputs during a short period of neonatal development prior to the first cross-modal experience affects feed-forward subcortico-cortical interactions by attenuating the cross-modal enhancement of evoked responses in the adult primary somatosensory cortex. Moreover, the neonatal manipulation alters cortico-cortical interactions by decreasing the cross-modal synchrony and directionality in line with the sparsification of direct projections between primary somatosensory and visual cortices. At the behavioral level, these functional and structural deficits resulted in lower cross-modal matching abilities. Thus, neonatal unimodal experience during defined developmental stages is necessary for setting up the neuronal networks of multisensory processing.
first_indexed 2024-12-14T16:56:25Z
format Article
id doaj.art-a6fc7e9d8eb04c9ba001febf96191850
institution Directory Open Access Journal
issn 1544-9173
1545-7885
language English
last_indexed 2024-12-14T16:56:25Z
publishDate 2015-01-01
publisher Public Library of Science (PLoS)
record_format Article
series PLoS Biology
spelling doaj.art-a6fc7e9d8eb04c9ba001febf961918502022-12-21T22:53:58ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852015-01-011311e100230410.1371/journal.pbio.1002304Neonatal Restriction of Tactile Inputs Leads to Long-Lasting Impairments of Cross-Modal Processing.Kay SiebenMalte BielerBrigitte RöderIleana L Hanganu-OpatzOptimal behavior relies on the combination of inputs from multiple senses through complex interactions within neocortical networks. The ontogeny of this multisensory interplay is still unknown. Here, we identify critical factors that control the development of visual-tactile processing by combining in vivo electrophysiology with anatomical/functional assessment of cortico-cortical communication and behavioral investigation of pigmented rats. We demonstrate that the transient reduction of unimodal (tactile) inputs during a short period of neonatal development prior to the first cross-modal experience affects feed-forward subcortico-cortical interactions by attenuating the cross-modal enhancement of evoked responses in the adult primary somatosensory cortex. Moreover, the neonatal manipulation alters cortico-cortical interactions by decreasing the cross-modal synchrony and directionality in line with the sparsification of direct projections between primary somatosensory and visual cortices. At the behavioral level, these functional and structural deficits resulted in lower cross-modal matching abilities. Thus, neonatal unimodal experience during defined developmental stages is necessary for setting up the neuronal networks of multisensory processing.http://europepmc.org/articles/PMC4658190?pdf=render
spellingShingle Kay Sieben
Malte Bieler
Brigitte Röder
Ileana L Hanganu-Opatz
Neonatal Restriction of Tactile Inputs Leads to Long-Lasting Impairments of Cross-Modal Processing.
PLoS Biology
title Neonatal Restriction of Tactile Inputs Leads to Long-Lasting Impairments of Cross-Modal Processing.
title_full Neonatal Restriction of Tactile Inputs Leads to Long-Lasting Impairments of Cross-Modal Processing.
title_fullStr Neonatal Restriction of Tactile Inputs Leads to Long-Lasting Impairments of Cross-Modal Processing.
title_full_unstemmed Neonatal Restriction of Tactile Inputs Leads to Long-Lasting Impairments of Cross-Modal Processing.
title_short Neonatal Restriction of Tactile Inputs Leads to Long-Lasting Impairments of Cross-Modal Processing.
title_sort neonatal restriction of tactile inputs leads to long lasting impairments of cross modal processing
url http://europepmc.org/articles/PMC4658190?pdf=render
work_keys_str_mv AT kaysieben neonatalrestrictionoftactileinputsleadstolonglastingimpairmentsofcrossmodalprocessing
AT maltebieler neonatalrestrictionoftactileinputsleadstolonglastingimpairmentsofcrossmodalprocessing
AT brigitteroder neonatalrestrictionoftactileinputsleadstolonglastingimpairmentsofcrossmodalprocessing
AT ileanalhanganuopatz neonatalrestrictionoftactileinputsleadstolonglastingimpairmentsofcrossmodalprocessing