The Role of Cardiac T-Cadherin in the Indicating Heart Failure Severity of Patients with Non-Ischemic Dilated Cardiomyopathy
<i>Background and objectives</i>: T-cadherin (T-cad) is one of the adiponectin receptors abundantly expressed in the heart and blood vessels. Experimental studies show that T-cad sequesters adiponectin in cardiovascular tissues and is critical for adiponectin-mediated cardio-protection....
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MDPI AG
2020-01-01
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| Online Access: | https://www.mdpi.com/1010-660X/56/1/27 |
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| author | Vaida Baltrūnienė Ieva Rinkūnaitė Julius Bogomolovas Daiva Bironaitė Ieva Kažukauskienė Egidijus Šimoliūnas Kęstutis Ručinskas Roma Puronaitė Virginija Bukelskienė Virginija Grabauskienė |
| author_facet | Vaida Baltrūnienė Ieva Rinkūnaitė Julius Bogomolovas Daiva Bironaitė Ieva Kažukauskienė Egidijus Šimoliūnas Kęstutis Ručinskas Roma Puronaitė Virginija Bukelskienė Virginija Grabauskienė |
| author_sort | Vaida Baltrūnienė |
| collection | DOAJ |
| description | <i>Background and objectives</i>: T-cadherin (T-cad) is one of the adiponectin receptors abundantly expressed in the heart and blood vessels. Experimental studies show that T-cad sequesters adiponectin in cardiovascular tissues and is critical for adiponectin-mediated cardio-protection. However, there are no data connecting cardiac T-cad levels with human chronic heart failure (HF). The aim of this study was to assess whether myocardial T-cad concentration is associated with chronic HF severity and whether the T-cad levels in human heart tissue might predict outcomes in patients with non-ischemic dilated cardiomyopathy (NI-DCM). <i>Materials and Methods:</i> 29 patients with chronic NI-DCM and advanced HF were enrolled. Patients underwent regular laboratory investigations, echocardiography, coronary angiography, and right heart catheterization. TNF-α and IL6 in serum were detected by enzyme-linked immunosorbent assay (ELISA). Additionally, endomyocardial biopsies were obtained, and the levels of T-cad were assessed by ELISA and CD3, CD45Ro, CD68, and CD4- immunohistochemically. Mean pulmonary capillary wedge pressure (PCWP) was used as a marker of HF severity, subdividing patients into two groups: mean PCWP > 19 mmHg vs. mean PCWP < 19 mmHg. Patients were followed-up for 5 years. The study outcome was composite: left ventricular assist device implantation, heart transplantation, or death from cardiovascular causes. <i>Results:</i> T-cad shows an inverse correlation with the mean PCWP (rho = −0.397, <i>p</i> = 0.037). There is a tendency towards a lower T-cad concentration in patients with more severe HF, as indicated by the mean PCWP > 19 mmHg compared to those with mean PCWP ≤ 19 mmHg (<i>p</i> = 0.058). Cardiac T-cad levels correlate negatively with myocardial CD3 cell count (rho = −0.423, <i>p</i> = 0.028). <i>Conclusions:</i> Univariate Cox regression analysis did not prove T-cad to be an outcome predictor (HR = 1, <i>p</i> = 0.349). However, decreased T-cad levels in human myocardium can be an additional indicator of HF severity. T-cad in human myocardium has an anti-inflammatory role. More studies are needed to extend the role of T-cad in the outcome prediction of patients with NI-DCM. |
| first_indexed | 2024-03-12T09:04:57Z |
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| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T09:04:57Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
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| series | Medicina |
| spelling | doaj.art-a6fd550b3c6c4ebb9c36d3fab0a4717d2023-09-02T15:25:30ZengMDPI AGMedicina1010-660X2020-01-015612710.3390/medicina56010027medicina56010027The Role of Cardiac T-Cadherin in the Indicating Heart Failure Severity of Patients with Non-Ischemic Dilated CardiomyopathyVaida Baltrūnienė0Ieva Rinkūnaitė1Julius Bogomolovas2Daiva Bironaitė3Ieva Kažukauskienė4Egidijus Šimoliūnas5Kęstutis Ručinskas6Roma Puronaitė7Virginija Bukelskienė8Virginija Grabauskienė9Department of Pathology, Forensic Medicine and Pharmacology, Faculty of Medicine, Vilnius University, 01513 Vilnius, LithuaniaInstitute of Biochemistry, Life Sciences Center, Vilnius University, 01513 Vilnius, LithuaniaDepartment of Medicine, University of California, San Diego, CA 92093, USADepartment of Regenerative Medicine, State Research Institute, Center for Innovative Medicine, 08410 Vilnius, LithuaniaDepartment of Pathology, Forensic Medicine and Pharmacology, Faculty of Medicine, Vilnius University, 01513 Vilnius, LithuaniaInstitute of Biochemistry, Life Sciences Center, Vilnius University, 01513 Vilnius, LithuaniaCenter of Cardiac Surgery, Clinic of Cardiac and Vascular Diseases, Faculty of Medicine, Vilnius University, 01513 Vilnius, LithuaniaClinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, 01513 Vilnius, LithuaniaInstitute of Biochemistry, Life Sciences Center, Vilnius University, 01513 Vilnius, LithuaniaDepartment of Pathology, Forensic Medicine and Pharmacology, Faculty of Medicine, Vilnius University, 01513 Vilnius, Lithuania<i>Background and objectives</i>: T-cadherin (T-cad) is one of the adiponectin receptors abundantly expressed in the heart and blood vessels. Experimental studies show that T-cad sequesters adiponectin in cardiovascular tissues and is critical for adiponectin-mediated cardio-protection. However, there are no data connecting cardiac T-cad levels with human chronic heart failure (HF). The aim of this study was to assess whether myocardial T-cad concentration is associated with chronic HF severity and whether the T-cad levels in human heart tissue might predict outcomes in patients with non-ischemic dilated cardiomyopathy (NI-DCM). <i>Materials and Methods:</i> 29 patients with chronic NI-DCM and advanced HF were enrolled. Patients underwent regular laboratory investigations, echocardiography, coronary angiography, and right heart catheterization. TNF-α and IL6 in serum were detected by enzyme-linked immunosorbent assay (ELISA). Additionally, endomyocardial biopsies were obtained, and the levels of T-cad were assessed by ELISA and CD3, CD45Ro, CD68, and CD4- immunohistochemically. Mean pulmonary capillary wedge pressure (PCWP) was used as a marker of HF severity, subdividing patients into two groups: mean PCWP > 19 mmHg vs. mean PCWP < 19 mmHg. Patients were followed-up for 5 years. The study outcome was composite: left ventricular assist device implantation, heart transplantation, or death from cardiovascular causes. <i>Results:</i> T-cad shows an inverse correlation with the mean PCWP (rho = −0.397, <i>p</i> = 0.037). There is a tendency towards a lower T-cad concentration in patients with more severe HF, as indicated by the mean PCWP > 19 mmHg compared to those with mean PCWP ≤ 19 mmHg (<i>p</i> = 0.058). Cardiac T-cad levels correlate negatively with myocardial CD3 cell count (rho = −0.423, <i>p</i> = 0.028). <i>Conclusions:</i> Univariate Cox regression analysis did not prove T-cad to be an outcome predictor (HR = 1, <i>p</i> = 0.349). However, decreased T-cad levels in human myocardium can be an additional indicator of HF severity. T-cad in human myocardium has an anti-inflammatory role. More studies are needed to extend the role of T-cad in the outcome prediction of patients with NI-DCM.https://www.mdpi.com/1010-660X/56/1/27adiponectinadvanced heart failurenon-ischemic dilated cardiomyopathyt-cadherin |
| spellingShingle | Vaida Baltrūnienė Ieva Rinkūnaitė Julius Bogomolovas Daiva Bironaitė Ieva Kažukauskienė Egidijus Šimoliūnas Kęstutis Ručinskas Roma Puronaitė Virginija Bukelskienė Virginija Grabauskienė The Role of Cardiac T-Cadherin in the Indicating Heart Failure Severity of Patients with Non-Ischemic Dilated Cardiomyopathy Medicina adiponectin advanced heart failure non-ischemic dilated cardiomyopathy t-cadherin |
| title | The Role of Cardiac T-Cadherin in the Indicating Heart Failure Severity of Patients with Non-Ischemic Dilated Cardiomyopathy |
| title_full | The Role of Cardiac T-Cadherin in the Indicating Heart Failure Severity of Patients with Non-Ischemic Dilated Cardiomyopathy |
| title_fullStr | The Role of Cardiac T-Cadherin in the Indicating Heart Failure Severity of Patients with Non-Ischemic Dilated Cardiomyopathy |
| title_full_unstemmed | The Role of Cardiac T-Cadherin in the Indicating Heart Failure Severity of Patients with Non-Ischemic Dilated Cardiomyopathy |
| title_short | The Role of Cardiac T-Cadherin in the Indicating Heart Failure Severity of Patients with Non-Ischemic Dilated Cardiomyopathy |
| title_sort | role of cardiac t cadherin in the indicating heart failure severity of patients with non ischemic dilated cardiomyopathy |
| topic | adiponectin advanced heart failure non-ischemic dilated cardiomyopathy t-cadherin |
| url | https://www.mdpi.com/1010-660X/56/1/27 |
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