Roadmap to Building a Cell: An Evolutionary Approach
Laboratory synthesis of an elementary biological cell from isolated components may aid in understanding of the fundamental principles of life and will provide a platform for a range of bioengineering and medical applications. In essence, building a cell consists in the integration of cellular module...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-08-01
|
| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fbioe.2020.00927/full |
| _version_ | 1818276869592580096 |
|---|---|
| author | Zhanar Abil Christophe Danelon |
| author_facet | Zhanar Abil Christophe Danelon |
| author_sort | Zhanar Abil |
| collection | DOAJ |
| description | Laboratory synthesis of an elementary biological cell from isolated components may aid in understanding of the fundamental principles of life and will provide a platform for a range of bioengineering and medical applications. In essence, building a cell consists in the integration of cellular modules into system’s level functionalities satisfying a definition of life. To achieve this goal, we propose in this perspective to undertake a semi-rational, system’s level evolutionary approach. The strategy would require iterative cycles of genetic integration of functional modules, diversification of hereditary information, compartmentalized gene expression, selection/screening, and possibly, assistance from open-ended evolution. We explore the underlying challenges to each of these steps and discuss possible solutions toward the bottom-up construction of an artificial living cell. |
| first_indexed | 2024-12-12T22:52:30Z |
| format | Article |
| id | doaj.art-a6fd7e1fd13d4f71b89447ab40d43ac5 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-12T22:52:30Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-a6fd7e1fd13d4f71b89447ab40d43ac52022-12-22T00:09:02ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852020-08-01810.3389/fbioe.2020.00927565069Roadmap to Building a Cell: An Evolutionary ApproachZhanar AbilChristophe DanelonLaboratory synthesis of an elementary biological cell from isolated components may aid in understanding of the fundamental principles of life and will provide a platform for a range of bioengineering and medical applications. In essence, building a cell consists in the integration of cellular modules into system’s level functionalities satisfying a definition of life. To achieve this goal, we propose in this perspective to undertake a semi-rational, system’s level evolutionary approach. The strategy would require iterative cycles of genetic integration of functional modules, diversification of hereditary information, compartmentalized gene expression, selection/screening, and possibly, assistance from open-ended evolution. We explore the underlying challenges to each of these steps and discuss possible solutions toward the bottom-up construction of an artificial living cell.https://www.frontiersin.org/article/10.3389/fbioe.2020.00927/fullsynthetic cellartificial cellliposomebottom-up synthetic biologydirected evolutionsystem’s level evolution |
| spellingShingle | Zhanar Abil Christophe Danelon Roadmap to Building a Cell: An Evolutionary Approach Frontiers in Bioengineering and Biotechnology synthetic cell artificial cell liposome bottom-up synthetic biology directed evolution system’s level evolution |
| title | Roadmap to Building a Cell: An Evolutionary Approach |
| title_full | Roadmap to Building a Cell: An Evolutionary Approach |
| title_fullStr | Roadmap to Building a Cell: An Evolutionary Approach |
| title_full_unstemmed | Roadmap to Building a Cell: An Evolutionary Approach |
| title_short | Roadmap to Building a Cell: An Evolutionary Approach |
| title_sort | roadmap to building a cell an evolutionary approach |
| topic | synthetic cell artificial cell liposome bottom-up synthetic biology directed evolution system’s level evolution |
| url | https://www.frontiersin.org/article/10.3389/fbioe.2020.00927/full |
| work_keys_str_mv | AT zhanarabil roadmaptobuildingacellanevolutionaryapproach AT christophedanelon roadmaptobuildingacellanevolutionaryapproach |