Can neutrophil-to-lymphocyte ratio and proatherogenic risk factors improve the accuracy of pneumonia severity index in the prediction of community acquired pneumonia outcome in healthy individuals?
Aim To investigate influence of neutrophil-to-lymphocyte ratio (NLR) and proatherogenic risk factors to improve the accuracy of pneumonia severity index (PSI) in the prediction of community acquired pneumonia (CAP) outcome in healthy individuals. Methods A retrospective observational cross-sectiona...
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| Format: | Article |
| Language: | English |
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Medical Association of Zenica-Doboj Canton
2022-08-01
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| Series: | Medicinski Glasnik |
| Subjects: | |
| Online Access: | https://ljkzedo.ba/mgpdf/mg37/01_Mujakovic_1464_A.pdf |
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| author | Aida Mujaković Belma Paralija Orhan Lepara Almir Fajkić Avdo Kurtović Besim Prnjavorac Edin Begić Nejra Gondžetović-Ćorić |
| author_facet | Aida Mujaković Belma Paralija Orhan Lepara Almir Fajkić Avdo Kurtović Besim Prnjavorac Edin Begić Nejra Gondžetović-Ćorić |
| author_sort | Aida Mujaković |
| collection | DOAJ |
| description | Aim To investigate influence of neutrophil-to-lymphocyte ratio (NLR) and proatherogenic risk factors to improve the accuracy of pneumonia severity index (PSI) in the prediction of community acquired pneumonia (CAP) outcome in healthy individuals.
Methods A retrospective observational cross-sectional study conducted at the Clinic for Pulmonary Diseases and Tuberculosis “Podhrastovi”, University Clinical Centre Sarajevo, included 83 patients with the diagnosis of CAP during the period March 2019-March 2021. Once diagnosed with CAP, PSI score was calculated and according to its value the need for hospital treatment was identified. Patients were divided in two groups: low risk of CAP (PSI <90), and high risk of CAP (PSI> 90).
Results The overall average hospital stay was 22.76±10.154 days. In the patients diagnosed with CAP, a positive correlation was established between the following parameters PSI score and age (r=0.670; p<0.01), C-reactive protein-CRP (rho=0.287; p<0.01), leukocytes (rho=0.406; p<0.01), NLR (rho=0.313; p<0.01) and platelet to lymphocyte ratio (PLR) (0.296; p<0.05). CRP, leukocytes, NLR and PLR were statistically significantly higher in patients with high risk of CAP compared to patients with low risk of CAP. Diastolic blood pressure, lymphocytes, eosinophils were significantly lower in patients with high risk of CAP (p<0.05;) compared to patients with low risk of CAP (p<0.01). The optimal cut-off value of NLR for CAP patients was 3.089 with an estimated area under curve (AUC) of 0.664.
Conclusion Proatherogenic parameters such as age, systolic blood pressure and leukocytes in combination with neutrophil-lymphocyte count ratio could improve accuracy of the pneumonia severity index in community acquired pneumonia outcome. |
| first_indexed | 2024-03-12T13:56:06Z |
| format | Article |
| id | doaj.art-a6ffa7d0abf44f64977fe1c61fb1b6cb |
| institution | Directory Open Access Journal |
| issn | 1840-0132 1840-2445 |
| language | English |
| last_indexed | 2024-03-12T13:56:06Z |
| publishDate | 2022-08-01 |
| publisher | Medical Association of Zenica-Doboj Canton |
| record_format | Article |
| series | Medicinski Glasnik |
| spelling | doaj.art-a6ffa7d0abf44f64977fe1c61fb1b6cb2023-08-22T14:57:18ZengMedical Association of Zenica-Doboj CantonMedicinski Glasnik1840-01321840-24452022-08-0119216016510.17392/1464-22Can neutrophil-to-lymphocyte ratio and proatherogenic risk factors improve the accuracy of pneumonia severity index in the prediction of community acquired pneumonia outcome in healthy individuals?Aida Mujaković0Belma Paralija1Orhan Lepara2Almir Fajkić3Avdo Kurtović4Besim Prnjavorac5Edin Begić6Nejra Gondžetović-Ćorić7Department of Pulmonology, General Hospital “Prim. dr. Abdulah Nakaš“; Department of Pathophysiology, School of Medicine, Sarajevo School of Science and TechnologyClinic for Pulmonary Diseases and Tuberculosis “Podhrastovi”, University Clinical CentreDepartment of Physiology, School of Medicine, University of SarajevoDepartment of Pathophysiology, School of Medicine, University of Sarajevo; SarajevoPrimary Healthcare Centre GračanicaDepartment of Pathophysiology, School of Medicine, Sarajevo School of Science and Technology; Department of Pulmonology, General Hospital TešanjDepartment of Pharmacology, Toxicology and Clinical Pharmacology, School of Medicine, Sarajevo School of Science and Technology; Department of Cardiology, General Hospital “Prim. dr. Abdulah Nakaš“Department of Radiology, General Hospital “Prim. dr. Abdulah Nakaš“; Sarajevo, Bosnia and HerzegovinaAim To investigate influence of neutrophil-to-lymphocyte ratio (NLR) and proatherogenic risk factors to improve the accuracy of pneumonia severity index (PSI) in the prediction of community acquired pneumonia (CAP) outcome in healthy individuals. Methods A retrospective observational cross-sectional study conducted at the Clinic for Pulmonary Diseases and Tuberculosis “Podhrastovi”, University Clinical Centre Sarajevo, included 83 patients with the diagnosis of CAP during the period March 2019-March 2021. Once diagnosed with CAP, PSI score was calculated and according to its value the need for hospital treatment was identified. Patients were divided in two groups: low risk of CAP (PSI <90), and high risk of CAP (PSI> 90). Results The overall average hospital stay was 22.76±10.154 days. In the patients diagnosed with CAP, a positive correlation was established between the following parameters PSI score and age (r=0.670; p<0.01), C-reactive protein-CRP (rho=0.287; p<0.01), leukocytes (rho=0.406; p<0.01), NLR (rho=0.313; p<0.01) and platelet to lymphocyte ratio (PLR) (0.296; p<0.05). CRP, leukocytes, NLR and PLR were statistically significantly higher in patients with high risk of CAP compared to patients with low risk of CAP. Diastolic blood pressure, lymphocytes, eosinophils were significantly lower in patients with high risk of CAP (p<0.05;) compared to patients with low risk of CAP (p<0.01). The optimal cut-off value of NLR for CAP patients was 3.089 with an estimated area under curve (AUC) of 0.664. Conclusion Proatherogenic parameters such as age, systolic blood pressure and leukocytes in combination with neutrophil-lymphocyte count ratio could improve accuracy of the pneumonia severity index in community acquired pneumonia outcome.https://ljkzedo.ba/mgpdf/mg37/01_Mujakovic_1464_A.pdfatherosclerosisinflammationlung |
| spellingShingle | Aida Mujaković Belma Paralija Orhan Lepara Almir Fajkić Avdo Kurtović Besim Prnjavorac Edin Begić Nejra Gondžetović-Ćorić Can neutrophil-to-lymphocyte ratio and proatherogenic risk factors improve the accuracy of pneumonia severity index in the prediction of community acquired pneumonia outcome in healthy individuals? Medicinski Glasnik atherosclerosis inflammation lung |
| title | Can neutrophil-to-lymphocyte ratio and proatherogenic risk factors improve the accuracy of pneumonia severity index in the prediction of community acquired pneumonia outcome in healthy individuals? |
| title_full | Can neutrophil-to-lymphocyte ratio and proatherogenic risk factors improve the accuracy of pneumonia severity index in the prediction of community acquired pneumonia outcome in healthy individuals? |
| title_fullStr | Can neutrophil-to-lymphocyte ratio and proatherogenic risk factors improve the accuracy of pneumonia severity index in the prediction of community acquired pneumonia outcome in healthy individuals? |
| title_full_unstemmed | Can neutrophil-to-lymphocyte ratio and proatherogenic risk factors improve the accuracy of pneumonia severity index in the prediction of community acquired pneumonia outcome in healthy individuals? |
| title_short | Can neutrophil-to-lymphocyte ratio and proatherogenic risk factors improve the accuracy of pneumonia severity index in the prediction of community acquired pneumonia outcome in healthy individuals? |
| title_sort | can neutrophil to lymphocyte ratio and proatherogenic risk factors improve the accuracy of pneumonia severity index in the prediction of community acquired pneumonia outcome in healthy individuals |
| topic | atherosclerosis inflammation lung |
| url | https://ljkzedo.ba/mgpdf/mg37/01_Mujakovic_1464_A.pdf |
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