A Drosophila model for developmental nicotine exposure.
Despite the known health risks of tobacco smoking, many people including pregnant women continue smoking. The effects of developmental nicotine exposure are known, but the underlying mechanisms are not well understood. Drosophila melanogaster is a model organism that can be used for uncovering genet...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0177710 |
| _version_ | 1818444304080699392 |
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| author | Norma Andrea Velazquez-Ulloa |
| author_facet | Norma Andrea Velazquez-Ulloa |
| author_sort | Norma Andrea Velazquez-Ulloa |
| collection | DOAJ |
| description | Despite the known health risks of tobacco smoking, many people including pregnant women continue smoking. The effects of developmental nicotine exposure are known, but the underlying mechanisms are not well understood. Drosophila melanogaster is a model organism that can be used for uncovering genetic and molecular mechanisms for drugs of abuse. Here I show that Drosophila can be a model to elucidate the mechanisms for nicotine's effects on a developing organism. Drosophila reared on nicotine food display developmental and behavioral effects similar to those in mammals including decreased survival and weight, increased developmental time, and decreased sensitivity to acute nicotine and ethanol. The Drosophila nicotinic acetylcholine receptor subunit alpha 7 (Dα7) mediates some of these effects. A novel role for Dα7 on ethanol sedation in Drosophila is also shown. Future research taking advantage of the genetic and molecular tools for Drosophila will allow additional discovery of the mechanisms behind the effects of nicotine during development. |
| first_indexed | 2024-12-14T19:13:48Z |
| format | Article |
| id | doaj.art-a70013bba11746b18fb68786e27605b5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T19:13:48Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a70013bba11746b18fb68786e27605b52022-12-21T22:50:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01125e017771010.1371/journal.pone.0177710A Drosophila model for developmental nicotine exposure.Norma Andrea Velazquez-UlloaDespite the known health risks of tobacco smoking, many people including pregnant women continue smoking. The effects of developmental nicotine exposure are known, but the underlying mechanisms are not well understood. Drosophila melanogaster is a model organism that can be used for uncovering genetic and molecular mechanisms for drugs of abuse. Here I show that Drosophila can be a model to elucidate the mechanisms for nicotine's effects on a developing organism. Drosophila reared on nicotine food display developmental and behavioral effects similar to those in mammals including decreased survival and weight, increased developmental time, and decreased sensitivity to acute nicotine and ethanol. The Drosophila nicotinic acetylcholine receptor subunit alpha 7 (Dα7) mediates some of these effects. A novel role for Dα7 on ethanol sedation in Drosophila is also shown. Future research taking advantage of the genetic and molecular tools for Drosophila will allow additional discovery of the mechanisms behind the effects of nicotine during development.https://doi.org/10.1371/journal.pone.0177710 |
| spellingShingle | Norma Andrea Velazquez-Ulloa A Drosophila model for developmental nicotine exposure. PLoS ONE |
| title | A Drosophila model for developmental nicotine exposure. |
| title_full | A Drosophila model for developmental nicotine exposure. |
| title_fullStr | A Drosophila model for developmental nicotine exposure. |
| title_full_unstemmed | A Drosophila model for developmental nicotine exposure. |
| title_short | A Drosophila model for developmental nicotine exposure. |
| title_sort | drosophila model for developmental nicotine exposure |
| url | https://doi.org/10.1371/journal.pone.0177710 |
| work_keys_str_mv | AT normaandreavelazquezulloa adrosophilamodelfordevelopmentalnicotineexposure AT normaandreavelazquezulloa drosophilamodelfordevelopmentalnicotineexposure |