The Endocannabinoid System and Invertebrate Neurodevelopment and Regeneration

Cannabis has long been used for its medicinal and psychoactive properties. With the relatively new adoption of formal medicinal cannabis regulations worldwide, the study of cannabinoids, both endogenous and exogenous, has similarly flourished in more recent decades. In particular, research investiga...

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Main Authors: Tristyn L. Clarke, Rachael L. Johnson, Jonathan J. Simone, Robert L. Carlone
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/22/4/2103
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author Tristyn L. Clarke
Rachael L. Johnson
Jonathan J. Simone
Robert L. Carlone
author_facet Tristyn L. Clarke
Rachael L. Johnson
Jonathan J. Simone
Robert L. Carlone
author_sort Tristyn L. Clarke
collection DOAJ
description Cannabis has long been used for its medicinal and psychoactive properties. With the relatively new adoption of formal medicinal cannabis regulations worldwide, the study of cannabinoids, both endogenous and exogenous, has similarly flourished in more recent decades. In particular, research investigating the role of cannabinoids in regeneration and neurodevelopment has yielded promising results in vertebrate models. However, regeneration-competent vertebrates are few, whereas a myriad of invertebrate species have been established as superb models for regeneration. As such, this review aims to provide a comprehensive summary of the endocannabinoid system, with a focus on current advances in the area of endocannabinoid system contributions to invertebrate neurodevelopment and regeneration.
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spelling doaj.art-a700ac9825664fabb784a555b81685a02023-12-11T17:48:53ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-02-01224210310.3390/ijms22042103The Endocannabinoid System and Invertebrate Neurodevelopment and RegenerationTristyn L. Clarke0Rachael L. Johnson1Jonathan J. Simone2Robert L. Carlone3Department of Biological Sciences, Brock University, 1812 Sir Isaac brock Way, St. Catharines, ON L2S 3A1, CanadaDepartment of Biological Sciences, Brock University, 1812 Sir Isaac brock Way, St. Catharines, ON L2S 3A1, CanadaDepartment of Biological Sciences, Brock University, 1812 Sir Isaac brock Way, St. Catharines, ON L2S 3A1, CanadaDepartment of Biological Sciences, Brock University, 1812 Sir Isaac brock Way, St. Catharines, ON L2S 3A1, CanadaCannabis has long been used for its medicinal and psychoactive properties. With the relatively new adoption of formal medicinal cannabis regulations worldwide, the study of cannabinoids, both endogenous and exogenous, has similarly flourished in more recent decades. In particular, research investigating the role of cannabinoids in regeneration and neurodevelopment has yielded promising results in vertebrate models. However, regeneration-competent vertebrates are few, whereas a myriad of invertebrate species have been established as superb models for regeneration. As such, this review aims to provide a comprehensive summary of the endocannabinoid system, with a focus on current advances in the area of endocannabinoid system contributions to invertebrate neurodevelopment and regeneration.https://www.mdpi.com/1422-0067/22/4/2103AEA2-AGCB1CB2endocannabinoidregeneration
spellingShingle Tristyn L. Clarke
Rachael L. Johnson
Jonathan J. Simone
Robert L. Carlone
The Endocannabinoid System and Invertebrate Neurodevelopment and Regeneration
International Journal of Molecular Sciences
AEA
2-AG
CB1
CB2
endocannabinoid
regeneration
title The Endocannabinoid System and Invertebrate Neurodevelopment and Regeneration
title_full The Endocannabinoid System and Invertebrate Neurodevelopment and Regeneration
title_fullStr The Endocannabinoid System and Invertebrate Neurodevelopment and Regeneration
title_full_unstemmed The Endocannabinoid System and Invertebrate Neurodevelopment and Regeneration
title_short The Endocannabinoid System and Invertebrate Neurodevelopment and Regeneration
title_sort endocannabinoid system and invertebrate neurodevelopment and regeneration
topic AEA
2-AG
CB1
CB2
endocannabinoid
regeneration
url https://www.mdpi.com/1422-0067/22/4/2103
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