Total Synthesis of the Highly N-Methylated Peptides Carmabin A and Dragomabin
The first total synthesis of carmabin A and dragomabin was achieved at 52.3 mg and 43.8 mg scale, respectively. The synthesis led to determination of the configuration of carmabin A and reassignment of the configuration of dragomabin at the stereogenic centre on the alkyne-bearing fragment.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-09-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/16/9/338 |
| _version_ | 1828274715702067200 |
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| author | Baijun Ye Peng Jiang Tingrong Zhang Yuanjun Sun Xin Hao Yingjun Cui Liang Wang Yue Chen |
| author_facet | Baijun Ye Peng Jiang Tingrong Zhang Yuanjun Sun Xin Hao Yingjun Cui Liang Wang Yue Chen |
| author_sort | Baijun Ye |
| collection | DOAJ |
| description | The first total synthesis of carmabin A and dragomabin was achieved at 52.3 mg and 43.8 mg scale, respectively. The synthesis led to determination of the configuration of carmabin A and reassignment of the configuration of dragomabin at the stereogenic centre on the alkyne-bearing fragment. |
| first_indexed | 2024-04-13T06:38:35Z |
| format | Article |
| id | doaj.art-a700b1c922944072a6828b2e3a13e517 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-13T06:38:35Z |
| publishDate | 2018-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-a700b1c922944072a6828b2e3a13e5172022-12-22T02:57:48ZengMDPI AGMarine Drugs1660-33972018-09-0116933810.3390/md16090338md16090338Total Synthesis of the Highly N-Methylated Peptides Carmabin A and DragomabinBaijun Ye0Peng Jiang1Tingrong Zhang2Yuanjun Sun3Xin Hao4Yingjun Cui5Liang Wang6Yue Chen7The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, ChinaThe State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, ChinaThe State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, ChinaThe State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, ChinaThe State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, ChinaThe State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, ChinaThe State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, ChinaThe State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, ChinaThe first total synthesis of carmabin A and dragomabin was achieved at 52.3 mg and 43.8 mg scale, respectively. The synthesis led to determination of the configuration of carmabin A and reassignment of the configuration of dragomabin at the stereogenic centre on the alkyne-bearing fragment.http://www.mdpi.com/1660-3397/16/9/338total synthesisstereochemical determination/revisioncarmabin Adragomabin |
| spellingShingle | Baijun Ye Peng Jiang Tingrong Zhang Yuanjun Sun Xin Hao Yingjun Cui Liang Wang Yue Chen Total Synthesis of the Highly N-Methylated Peptides Carmabin A and Dragomabin Marine Drugs total synthesis stereochemical determination/revision carmabin A dragomabin |
| title | Total Synthesis of the Highly N-Methylated Peptides Carmabin A and Dragomabin |
| title_full | Total Synthesis of the Highly N-Methylated Peptides Carmabin A and Dragomabin |
| title_fullStr | Total Synthesis of the Highly N-Methylated Peptides Carmabin A and Dragomabin |
| title_full_unstemmed | Total Synthesis of the Highly N-Methylated Peptides Carmabin A and Dragomabin |
| title_short | Total Synthesis of the Highly N-Methylated Peptides Carmabin A and Dragomabin |
| title_sort | total synthesis of the highly n methylated peptides carmabin a and dragomabin |
| topic | total synthesis stereochemical determination/revision carmabin A dragomabin |
| url | http://www.mdpi.com/1660-3397/16/9/338 |
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