Sentinel lymph node mapping with superparamagnetic iron oxide for melanoma: a pilot study in healthy participants to establish an optimal MRI workflow protocol
Abstract Background Current pre-operative Sentinel Lymph Node (SLN) mapping using dual tracing is associated with drawbacks (radiation exposure, logistic challenges). Superparamagnetic iron oxide (SPIO) is a non-inferior alternative for SLN mapping in breast cancer patients. Limited research has bee...
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-022-10146-w |
| _version_ | 1811238866114314240 |
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| author | Loeki Aldenhoven Caroline Frotscher Rachelle Körver-Steeman Milou H. Martens Damir Kuburic Alfred Janssen Geerard L. Beets James van Bastelaar |
| author_facet | Loeki Aldenhoven Caroline Frotscher Rachelle Körver-Steeman Milou H. Martens Damir Kuburic Alfred Janssen Geerard L. Beets James van Bastelaar |
| author_sort | Loeki Aldenhoven |
| collection | DOAJ |
| description | Abstract Background Current pre-operative Sentinel Lymph Node (SLN) mapping using dual tracing is associated with drawbacks (radiation exposure, logistic challenges). Superparamagnetic iron oxide (SPIO) is a non-inferior alternative for SLN mapping in breast cancer patients. Limited research has been performed on SPIO use and pre-operative MRI in melanoma patients to identify SLNs. Methods Healthy participants underwent MRI-scanning pre- and post SPIO-injection during 20 min. Workflow protocols varied in dosage, massage duration, route of administration and injection sites. The first lymph node showing a susceptibility artefact caused by SPIO accumulation was considered as SLN. Results Artefacts were identified in 5/6 participants. Two participants received a 0.5 ml subcutaneous injection and 30-s massage, of which one showed an artefact after one hour. Four participants received a 1.0 ml intracutaneous injection and two-minute massage, leading to artefacts in all participants. All SLNs were observed within five minutes, except after lower limb injection (30 min). Conclusion SPIO and pre-operative MRI-scanning seems to be a promising alternative for SLN visualization in melanoma patients. An intracutaneous injection of 1.0 ml SPIO tracer, followed by a two-minute massage seems to be the most effective technique, simplifying the pre-operative pathway. Result will be used in a larger prospective study with melanoma patients. Trial registration ClinicalTrials.gov (NCT05054062) – September 9, 2021. |
| first_indexed | 2024-04-12T12:49:48Z |
| format | Article |
| id | doaj.art-a700ecc64a2d45a5bc70b0fafbc64123 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-12T12:49:48Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-a700ecc64a2d45a5bc70b0fafbc641232022-12-22T03:32:31ZengBMCBMC Cancer1471-24072022-10-012211710.1186/s12885-022-10146-wSentinel lymph node mapping with superparamagnetic iron oxide for melanoma: a pilot study in healthy participants to establish an optimal MRI workflow protocolLoeki Aldenhoven0Caroline Frotscher1Rachelle Körver-Steeman2Milou H. Martens3Damir Kuburic4Alfred Janssen5Geerard L. Beets6James van Bastelaar7Department of Surgery, Zuyderland Medical CenterDepartment of Radiology, Zuyderland Medical CenterDepartment of Radiology, Zuyderland Medical CenterDepartment of Surgery, Zuyderland Medical CenterDepartment of Radiology, Zuyderland Medical CenterDepartment of Surgery, Zuyderland Medical CenterPresent address: Department of Surgery, Zuyderland Medical CenterDepartment of Surgery, Zuyderland Medical CenterAbstract Background Current pre-operative Sentinel Lymph Node (SLN) mapping using dual tracing is associated with drawbacks (radiation exposure, logistic challenges). Superparamagnetic iron oxide (SPIO) is a non-inferior alternative for SLN mapping in breast cancer patients. Limited research has been performed on SPIO use and pre-operative MRI in melanoma patients to identify SLNs. Methods Healthy participants underwent MRI-scanning pre- and post SPIO-injection during 20 min. Workflow protocols varied in dosage, massage duration, route of administration and injection sites. The first lymph node showing a susceptibility artefact caused by SPIO accumulation was considered as SLN. Results Artefacts were identified in 5/6 participants. Two participants received a 0.5 ml subcutaneous injection and 30-s massage, of which one showed an artefact after one hour. Four participants received a 1.0 ml intracutaneous injection and two-minute massage, leading to artefacts in all participants. All SLNs were observed within five minutes, except after lower limb injection (30 min). Conclusion SPIO and pre-operative MRI-scanning seems to be a promising alternative for SLN visualization in melanoma patients. An intracutaneous injection of 1.0 ml SPIO tracer, followed by a two-minute massage seems to be the most effective technique, simplifying the pre-operative pathway. Result will be used in a larger prospective study with melanoma patients. Trial registration ClinicalTrials.gov (NCT05054062) – September 9, 2021.https://doi.org/10.1186/s12885-022-10146-wMagnetic iron oxide nanoparticlesSentinel lymph node biopsyMelanomaSurgical oncology |
| spellingShingle | Loeki Aldenhoven Caroline Frotscher Rachelle Körver-Steeman Milou H. Martens Damir Kuburic Alfred Janssen Geerard L. Beets James van Bastelaar Sentinel lymph node mapping with superparamagnetic iron oxide for melanoma: a pilot study in healthy participants to establish an optimal MRI workflow protocol BMC Cancer Magnetic iron oxide nanoparticles Sentinel lymph node biopsy Melanoma Surgical oncology |
| title | Sentinel lymph node mapping with superparamagnetic iron oxide for melanoma: a pilot study in healthy participants to establish an optimal MRI workflow protocol |
| title_full | Sentinel lymph node mapping with superparamagnetic iron oxide for melanoma: a pilot study in healthy participants to establish an optimal MRI workflow protocol |
| title_fullStr | Sentinel lymph node mapping with superparamagnetic iron oxide for melanoma: a pilot study in healthy participants to establish an optimal MRI workflow protocol |
| title_full_unstemmed | Sentinel lymph node mapping with superparamagnetic iron oxide for melanoma: a pilot study in healthy participants to establish an optimal MRI workflow protocol |
| title_short | Sentinel lymph node mapping with superparamagnetic iron oxide for melanoma: a pilot study in healthy participants to establish an optimal MRI workflow protocol |
| title_sort | sentinel lymph node mapping with superparamagnetic iron oxide for melanoma a pilot study in healthy participants to establish an optimal mri workflow protocol |
| topic | Magnetic iron oxide nanoparticles Sentinel lymph node biopsy Melanoma Surgical oncology |
| url | https://doi.org/10.1186/s12885-022-10146-w |
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