A New Sesquiterpenoid Hydroquinone from the Marine Sponge Dysidea arenaria
Detailed chemical investigation of the South China sponge Dysidea arenaria resulted in the isolation of a new sesquiterpenoid hydroquinone, 19-hydroxypolyfibrospongol B (1), along with five known compounds: polyfibrospongol B (2), isosemnonorthoquinone (3), ilimaquinone (4), smenospongine (5) and sm...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2008-06-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/13/6/1275/ |
| _version_ | 1818606959051407360 |
|---|---|
| author | Xiu Min Wang Yan Qiu |
| author_facet | Xiu Min Wang Yan Qiu |
| author_sort | Xiu Min Wang |
| collection | DOAJ |
| description | Detailed chemical investigation of the South China sponge Dysidea arenaria resulted in the isolation of a new sesquiterpenoid hydroquinone, 19-hydroxypolyfibrospongol B (1), along with five known compounds: polyfibrospongol B (2), isosemnonorthoquinone (3), ilimaquinone (4), smenospongine (5) and smenotronic acid (6). The structures were determined by extensive spectroscopic analysis. The in vitro anti- HIV activity on HIV-1 RT was evaluated. Compounds 3 -6 displayed moderate inhibitory activity, with IC50 values of 239.7, 16.4, 176.1, and 130.4 μM, respectively, while 1 and 2 were found to be inactive against the same biological target. |
| first_indexed | 2024-12-16T14:19:08Z |
| format | Article |
| id | doaj.art-a701696c806e40c9a0b3bb157a3b3530 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-16T14:19:08Z |
| publishDate | 2008-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-a701696c806e40c9a0b3bb157a3b35302022-12-21T22:28:34ZengMDPI AGMolecules1420-30492008-06-011361275128110.3390/molecules13061275A New Sesquiterpenoid Hydroquinone from the Marine Sponge Dysidea arenariaXiu Min WangYan QiuDetailed chemical investigation of the South China sponge Dysidea arenaria resulted in the isolation of a new sesquiterpenoid hydroquinone, 19-hydroxypolyfibrospongol B (1), along with five known compounds: polyfibrospongol B (2), isosemnonorthoquinone (3), ilimaquinone (4), smenospongine (5) and smenotronic acid (6). The structures were determined by extensive spectroscopic analysis. The in vitro anti- HIV activity on HIV-1 RT was evaluated. Compounds 3 -6 displayed moderate inhibitory activity, with IC50 values of 239.7, 16.4, 176.1, and 130.4 μM, respectively, while 1 and 2 were found to be inactive against the same biological target.http://www.mdpi.com/1420-3049/13/6/1275/Sesquiterpenoid hydroquinoneanti-HIV activityDysidea arenaria. |
| spellingShingle | Xiu Min Wang Yan Qiu A New Sesquiterpenoid Hydroquinone from the Marine Sponge Dysidea arenaria Molecules Sesquiterpenoid hydroquinone anti-HIV activity Dysidea arenaria. |
| title | A New Sesquiterpenoid Hydroquinone from the Marine Sponge Dysidea arenaria |
| title_full | A New Sesquiterpenoid Hydroquinone from the Marine Sponge Dysidea arenaria |
| title_fullStr | A New Sesquiterpenoid Hydroquinone from the Marine Sponge Dysidea arenaria |
| title_full_unstemmed | A New Sesquiterpenoid Hydroquinone from the Marine Sponge Dysidea arenaria |
| title_short | A New Sesquiterpenoid Hydroquinone from the Marine Sponge Dysidea arenaria |
| title_sort | new sesquiterpenoid hydroquinone from the marine sponge dysidea arenaria |
| topic | Sesquiterpenoid hydroquinone anti-HIV activity Dysidea arenaria. |
| url | http://www.mdpi.com/1420-3049/13/6/1275/ |
| work_keys_str_mv | AT xiuminwang anewsesquiterpenoidhydroquinonefromthemarinespongedysideaarenaria AT yanqiu anewsesquiterpenoidhydroquinonefromthemarinespongedysideaarenaria AT xiuminwang newsesquiterpenoidhydroquinonefromthemarinespongedysideaarenaria AT yanqiu newsesquiterpenoidhydroquinonefromthemarinespongedysideaarenaria |