Comparison of Buprenorphine and Buprenorphine/naloxone in Detoxification of Opioid-dependent Men
Background: Buprenorphine sublingual tablets are now available in Iran for opioid detoxification in clinics. Aim of the present study was to compare the efficiency of buprenorphine with buprenorphine/naloxone in short-term detoxification in a group of Iranian male opioid-dependent patients. Methods:...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Kerman University of Medical Sciences
2018-12-01
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| Series: | Addiction and Health |
| Subjects: | |
| Online Access: | https://ahj.kmu.ac.ir/article_87477_248f3e564078acb836990d5f6afa7deb.pdf |
| _version_ | 1827814895759917056 |
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| author | Hassan Ziaaddini Shima Heshmati Maryam Chegeni Mahboobeh Mousavi-Ramezanzade Shahrzad Mazhari |
| author_facet | Hassan Ziaaddini Shima Heshmati Maryam Chegeni Mahboobeh Mousavi-Ramezanzade Shahrzad Mazhari |
| author_sort | Hassan Ziaaddini |
| collection | DOAJ |
| description | Background: Buprenorphine sublingual tablets are now available in Iran for opioid detoxification in clinics. Aim of the present study was to compare the efficiency of buprenorphine with buprenorphine/naloxone in short-term detoxification in a group of Iranian male opioid-dependent patients.
Methods:A double-blind trial was carried out on a group of male opioid dependent patients in a psychiatric hospital in Kerman, Iran, during year 2017. A group of 100 men who met the diagnostic criteria for opiate dependence were included in the study from individuals who had referred for detoxification. They were allocated to the two groups receiving either buprenorphine (n = 51) or buprenorphine/naloxone (n = 49). Severity of withdrawal symptoms and signs were evaluated by Clinical Opiate Withdrawal Scale (COWS) and Adjective Rating Scale for Withdrawal (ARSW).
Findings: The mean scores of COWS and ARSW in the two groups treated with buprenorphine and buprenorphine/naloxone significantly reduced from the first day to the fifth day of detoxification (P < 0.050). Moreover, there was no significant difference between the two groups in terms of objective and subjective symptom reduction (P > 0.050).
Conclusion: Buprenorphine/naloxone is as effective as buprenorphine in controlling opiate withdrawal symptoms. |
| first_indexed | 2024-03-11T23:52:22Z |
| format | Article |
| id | doaj.art-a702c38ce783463e9858ffac2aca826b |
| institution | Directory Open Access Journal |
| issn | 2008-4633 2008-8469 |
| language | English |
| last_indexed | 2024-03-11T23:52:22Z |
| publishDate | 2018-12-01 |
| publisher | Kerman University of Medical Sciences |
| record_format | Article |
| series | Addiction and Health |
| spelling | doaj.art-a702c38ce783463e9858ffac2aca826b2023-09-19T06:47:07ZengKerman University of Medical SciencesAddiction and Health2008-46332008-84692018-12-0110426927510.22122/ahj.v10i4.67987477Comparison of Buprenorphine and Buprenorphine/naloxone in Detoxification of Opioid-dependent MenHassan Ziaaddini0Shima Heshmati1Maryam Chegeni2Mahboobeh Mousavi-Ramezanzade3Shahrzad Mazhari4Professor, Neuroscience Research Center, Neuropharmacology Institute AND Department of Psychiatry, School of Medicine, Kerman University of Medical Sciences, Kerman, IranPsychiatrist, Neuroscience Research Center, Neuropharmacology Institute AND Department of Psychiatry, School of Medicine, Kerman University of Medical Sciences, Kerman, IranPhD Student, HIV/STI Surveillance Research Center AND WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, IranDepartment of Biostatistics and Epidemiology, School of Public Health, Kerman University of Medical Sciences, Kerman, IrAssociate Professor, Neuroscience Research Center, Neuropharmacology Institute AND Department of Psychiatry, School of Medicine, Kerman University of Medical Sciences, Kerman, IranBackground: Buprenorphine sublingual tablets are now available in Iran for opioid detoxification in clinics. Aim of the present study was to compare the efficiency of buprenorphine with buprenorphine/naloxone in short-term detoxification in a group of Iranian male opioid-dependent patients. Methods:A double-blind trial was carried out on a group of male opioid dependent patients in a psychiatric hospital in Kerman, Iran, during year 2017. A group of 100 men who met the diagnostic criteria for opiate dependence were included in the study from individuals who had referred for detoxification. They were allocated to the two groups receiving either buprenorphine (n = 51) or buprenorphine/naloxone (n = 49). Severity of withdrawal symptoms and signs were evaluated by Clinical Opiate Withdrawal Scale (COWS) and Adjective Rating Scale for Withdrawal (ARSW). Findings: The mean scores of COWS and ARSW in the two groups treated with buprenorphine and buprenorphine/naloxone significantly reduced from the first day to the fifth day of detoxification (P < 0.050). Moreover, there was no significant difference between the two groups in terms of objective and subjective symptom reduction (P > 0.050). Conclusion: Buprenorphine/naloxone is as effective as buprenorphine in controlling opiate withdrawal symptoms.https://ahj.kmu.ac.ir/article_87477_248f3e564078acb836990d5f6afa7deb.pdfaddictiondetoxificationbuprenorphinebuprenorphine/naloxone |
| spellingShingle | Hassan Ziaaddini Shima Heshmati Maryam Chegeni Mahboobeh Mousavi-Ramezanzade Shahrzad Mazhari Comparison of Buprenorphine and Buprenorphine/naloxone in Detoxification of Opioid-dependent Men Addiction and Health addiction detoxification buprenorphine buprenorphine/naloxone |
| title | Comparison of Buprenorphine and Buprenorphine/naloxone in Detoxification of Opioid-dependent Men |
| title_full | Comparison of Buprenorphine and Buprenorphine/naloxone in Detoxification of Opioid-dependent Men |
| title_fullStr | Comparison of Buprenorphine and Buprenorphine/naloxone in Detoxification of Opioid-dependent Men |
| title_full_unstemmed | Comparison of Buprenorphine and Buprenorphine/naloxone in Detoxification of Opioid-dependent Men |
| title_short | Comparison of Buprenorphine and Buprenorphine/naloxone in Detoxification of Opioid-dependent Men |
| title_sort | comparison of buprenorphine and buprenorphine naloxone in detoxification of opioid dependent men |
| topic | addiction detoxification buprenorphine buprenorphine/naloxone |
| url | https://ahj.kmu.ac.ir/article_87477_248f3e564078acb836990d5f6afa7deb.pdf |
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