Cardiovascular risk in children and adolescents with end stage renal disease
OBJECTIVES: To evaluate cardiovascular involvement in children and adolescents with End Stage Renal Disease (ESRD) and to characterize the main risk factors associated with this outcome. METHODS: Cross-sectional study of 69 children and adolescents at renal transplantation and 33 healthy individual...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier España
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| Series: | Clinics |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322019000100239&lng=en&tlng=en |
| _version_ | 1811327077557731328 |
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| author | Maria Luiza do Val Fernanda Souza Menezes Henrique Tsuha Massaoka Valeska Tavares Scavarda Adriano Czapkowski Heitor Pons Leite Valdir Ambrósio Moises Sergio Aron Ajzen João Tomas de Abreu Carvalhaes José Osmar Medina Pestana Paulo Koch-Nogueira |
| author_facet | Maria Luiza do Val Fernanda Souza Menezes Henrique Tsuha Massaoka Valeska Tavares Scavarda Adriano Czapkowski Heitor Pons Leite Valdir Ambrósio Moises Sergio Aron Ajzen João Tomas de Abreu Carvalhaes José Osmar Medina Pestana Paulo Koch-Nogueira |
| author_sort | Maria Luiza do Val |
| collection | DOAJ |
| description | OBJECTIVES: To evaluate cardiovascular involvement in children and adolescents with End Stage Renal Disease (ESRD) and to characterize the main risk factors associated with this outcome. METHODS: Cross-sectional study of 69 children and adolescents at renal transplantation and 33 healthy individuals matched by age and gender. The study outcomes were left ventricular mass z-score (LVMZ) and carotid artery intima-media thickness (CIMT). The potential risk factors considered were age, gender, CKD etiology, use of oral vitamin D and calcium-based phosphate binders, systolic and diastolic blood pressure, body mass index z-score, time since diagnosis, dialysis duration, serum levels of ionic calcium, phosphorus, parathyroid hormone, fibroblast growth factor (FGF 23), uric acid, homocysteine, cholesterol, triglycerides, C-reactive protein (CRP), vitamin D and hemoglobin. RESULTS: In the multivariate analysis, the factors associated with LVMZ were dialysis duration, age, systolic blood pressure, serum hemoglobin and HDL cholesterol levels. Regarding CIMT, in the multivariate analysis, systolic blood pressure was the only factor associated with the outcome. CONCLUSION: Children exhibited important cardiovascular involvement at the time of the renal transplantation. Both of the studied outcomes were independently associated with systolic blood pressure. For this reason, controlling blood pressure seems to be the main therapy to minimize cardiovascular involvement in children with ESRD. |
| first_indexed | 2024-04-13T15:00:15Z |
| format | Article |
| id | doaj.art-a702d46de2e74acc8655962cb0afb2f1 |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-04-13T15:00:15Z |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-a702d46de2e74acc8655962cb0afb2f12022-12-22T02:42:18ZengElsevier EspañaClinics1980-53227410.6061/clinics/2019/e859S1807-59322019000100239Cardiovascular risk in children and adolescents with end stage renal diseaseMaria Luiza do ValFernanda Souza MenezesHenrique Tsuha MassaokaValeska Tavares ScavardaAdriano CzapkowskiHeitor Pons LeiteValdir Ambrósio MoisesSergio Aron AjzenJoão Tomas de Abreu CarvalhaesJosé Osmar Medina PestanaPaulo Koch-NogueiraOBJECTIVES: To evaluate cardiovascular involvement in children and adolescents with End Stage Renal Disease (ESRD) and to characterize the main risk factors associated with this outcome. METHODS: Cross-sectional study of 69 children and adolescents at renal transplantation and 33 healthy individuals matched by age and gender. The study outcomes were left ventricular mass z-score (LVMZ) and carotid artery intima-media thickness (CIMT). The potential risk factors considered were age, gender, CKD etiology, use of oral vitamin D and calcium-based phosphate binders, systolic and diastolic blood pressure, body mass index z-score, time since diagnosis, dialysis duration, serum levels of ionic calcium, phosphorus, parathyroid hormone, fibroblast growth factor (FGF 23), uric acid, homocysteine, cholesterol, triglycerides, C-reactive protein (CRP), vitamin D and hemoglobin. RESULTS: In the multivariate analysis, the factors associated with LVMZ were dialysis duration, age, systolic blood pressure, serum hemoglobin and HDL cholesterol levels. Regarding CIMT, in the multivariate analysis, systolic blood pressure was the only factor associated with the outcome. CONCLUSION: Children exhibited important cardiovascular involvement at the time of the renal transplantation. Both of the studied outcomes were independently associated with systolic blood pressure. For this reason, controlling blood pressure seems to be the main therapy to minimize cardiovascular involvement in children with ESRD.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322019000100239&lng=en&tlng=enChronic Kidney DiseaseCardiovascular DiseaseChildrenIntima-Media ThicknessEcocardiography |
| spellingShingle | Maria Luiza do Val Fernanda Souza Menezes Henrique Tsuha Massaoka Valeska Tavares Scavarda Adriano Czapkowski Heitor Pons Leite Valdir Ambrósio Moises Sergio Aron Ajzen João Tomas de Abreu Carvalhaes José Osmar Medina Pestana Paulo Koch-Nogueira Cardiovascular risk in children and adolescents with end stage renal disease Clinics Chronic Kidney Disease Cardiovascular Disease Children Intima-Media Thickness Ecocardiography |
| title | Cardiovascular risk in children and adolescents with end stage renal disease |
| title_full | Cardiovascular risk in children and adolescents with end stage renal disease |
| title_fullStr | Cardiovascular risk in children and adolescents with end stage renal disease |
| title_full_unstemmed | Cardiovascular risk in children and adolescents with end stage renal disease |
| title_short | Cardiovascular risk in children and adolescents with end stage renal disease |
| title_sort | cardiovascular risk in children and adolescents with end stage renal disease |
| topic | Chronic Kidney Disease Cardiovascular Disease Children Intima-Media Thickness Ecocardiography |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322019000100239&lng=en&tlng=en |
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