Intraindividual Comparison Between [18F] PSMA-1007 PET/CT and Multiparametric MRI for Radiotherapy Planning in Primary Prostate Cancer Patients
IntroductionAccurate detection and segmentation of the intraprostatic gross tumor volume (GTV) is pivotal for radiotherapy (RT) in primary prostate cancer (PCa) since it influences focal therapy target volumes and the patients’ cT stage. The study aimed to compare the performance of multiparametric...
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.880042/full |
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| author | Ioana M. Marinescu Ioana M. Marinescu Simon K. B. Spohn Simon K. B. Spohn Selina Kiefer Peter Bronsert Lara Ceci Lara Ceci Julius Holzschuh Julius Holzschuh August Sigle Cordula A. Jilg Alexander Rühle Alexander Rühle Tanja Sprave Tanja Sprave Nils H. Nicolay Nils H. Nicolay Robert Winzer Robert Winzer Jana Rehm Jana Rehm Jörg Kotzerke Jörg Kotzerke Tobias Hölscher Tobias Hölscher Anca L. Grosu Anca L. Grosu Juri Ruf Matthias Benndorf Constantinos Zamboglou Constantinos Zamboglou Constantinos Zamboglou Constantinos Zamboglou Constantinos Zamboglou |
| author_facet | Ioana M. Marinescu Ioana M. Marinescu Simon K. B. Spohn Simon K. B. Spohn Selina Kiefer Peter Bronsert Lara Ceci Lara Ceci Julius Holzschuh Julius Holzschuh August Sigle Cordula A. Jilg Alexander Rühle Alexander Rühle Tanja Sprave Tanja Sprave Nils H. Nicolay Nils H. Nicolay Robert Winzer Robert Winzer Jana Rehm Jana Rehm Jörg Kotzerke Jörg Kotzerke Tobias Hölscher Tobias Hölscher Anca L. Grosu Anca L. Grosu Juri Ruf Matthias Benndorf Constantinos Zamboglou Constantinos Zamboglou Constantinos Zamboglou Constantinos Zamboglou Constantinos Zamboglou |
| author_sort | Ioana M. Marinescu |
| collection | DOAJ |
| description | IntroductionAccurate detection and segmentation of the intraprostatic gross tumor volume (GTV) is pivotal for radiotherapy (RT) in primary prostate cancer (PCa) since it influences focal therapy target volumes and the patients’ cT stage. The study aimed to compare the performance of multiparametric resonance imaging (mpMRI) with [18F] PSMA-1007 positron emission tomography (PET) for intraprostatic GTV detection as well as delineation and to evaluate their respective influence on RT concepts.Materials and MethodsIn total, 93 patients from two German University Hospitals with [18F] PSMA-1007-PET/CT and MRI (Freiburg) or [18F] PSMA-1007-PET/MRI (Dresden) were retrospectively enrolled. Validated contouring techniques were applied for GTV-PET and -MRI segmentation. Absolute tumor volume and cT status were determined for each imaging method. The PCa distribution from histopathological reports based on biopsy cores and surgery specimen was used as reference in terms of laterality (unilateral vs. bilateral).ResultsIn the Freiburg cohort (n = 84), mpMRI and PET detected in median 2 (range: 1–5) and 3 (range: 1–8) GTVs, respectively (p < 0.01). The median GTV-MRI was significantly smaller than the GTV-PET, measuring 2.05 vs. 3.65 ml (p = 0.0005). PET had a statistically significant higher concordance in laterality with surgery specimen compared to mpMRI (p = 0.04) and biopsy (p < 0.01), respectively. PSMA PET led to more cT2c and cT3b stages, whereas cT3a stage was more pronounced in mpMRI. Based on the cT stage derived from mpMRI and PET information, 21 and 23 as well as 59 and 60 patients, respectively, were intermediate- and high-risk according to the National Comprehensive Cancer Network (NCCN) v1.2022 criteria. In the Dresden cohort (n = 9), similar results were observed.ConclusionIntraprostatic GTV segmentation based on [18F] PSMA-1007 PET results in more and larger GTVs compared to mpMRI. This influences focal RT target volumes and cT stage definition, but not the NCCN risk group. |
| first_indexed | 2024-04-12T09:09:33Z |
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| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T09:09:33Z |
| publishDate | 2022-07-01 |
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| series | Frontiers in Oncology |
| spelling | doaj.art-a70487c86c92447fa21b134636a950772022-12-22T03:39:00ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-07-011210.3389/fonc.2022.880042880042Intraindividual Comparison Between [18F] PSMA-1007 PET/CT and Multiparametric MRI for Radiotherapy Planning in Primary Prostate Cancer PatientsIoana M. Marinescu0Ioana M. Marinescu1Simon K. B. Spohn2Simon K. B. Spohn3Selina Kiefer4Peter Bronsert5Lara Ceci6Lara Ceci7Julius Holzschuh8Julius Holzschuh9August Sigle10Cordula A. Jilg11Alexander Rühle12Alexander Rühle13Tanja Sprave14Tanja Sprave15Nils H. Nicolay16Nils H. Nicolay17Robert Winzer18Robert Winzer19Jana Rehm20Jana Rehm21Jörg Kotzerke22Jörg Kotzerke23Tobias Hölscher24Tobias Hölscher25Anca L. Grosu26Anca L. Grosu27Juri Ruf28Matthias Benndorf29Constantinos Zamboglou30Constantinos Zamboglou31Constantinos Zamboglou32Constantinos Zamboglou33Constantinos Zamboglou34Department of Radiation Oncology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, GermanyGerman Cancer Consortium (DKTK) Partner Site Freiburg, Freiburg im Breisgau, GermanyDepartment of Radiation Oncology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, GermanyGerman Cancer Consortium (DKTK) Partner Site Freiburg, Freiburg im Breisgau, GermanyInstitute for Surgical Pathology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, GermanyInstitute for Surgical Pathology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, GermanyDepartment of Radiation Oncology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, GermanyGerman Cancer Consortium (DKTK) Partner Site Freiburg, Freiburg im Breisgau, GermanyDepartment of Radiation Oncology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, GermanyGerman Cancer Consortium (DKTK) Partner Site Freiburg, Freiburg im Breisgau, GermanyDepartment of Urology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, GermanyDepartment of Urology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, GermanyDepartment of Radiation Oncology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, GermanyGerman Cancer Consortium (DKTK) Partner Site Freiburg, Freiburg im Breisgau, GermanyDepartment of Radiation Oncology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, GermanyGerman Cancer Consortium (DKTK) Partner Site Freiburg, Freiburg im Breisgau, GermanyDepartment of Radiation Oncology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, GermanyGerman Cancer Consortium (DKTK) Partner Site Freiburg, Freiburg im Breisgau, GermanyDepartment of Nuclear Medicine, Faculty of Medicine, University of Dresden, Dresden, GermanyGerman Cancer Consortium (DKTK), Partner Site Dresden, Dresden, GermanyDepartment of Nuclear Medicine, Faculty of Medicine, University of Dresden, Dresden, GermanyGerman Cancer Consortium (DKTK), Partner Site Dresden, Dresden, GermanyDepartment of Nuclear Medicine, Faculty of Medicine, University of Dresden, Dresden, GermanyGerman Cancer Consortium (DKTK), Partner Site Dresden, Dresden, GermanyGerman Cancer Consortium (DKTK), Partner Site Dresden, Dresden, GermanyDepartment of Radiation Oncology, Faculty of Medicine, University of Dresden, Dresden, GermanyDepartment of Radiation Oncology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, GermanyGerman Cancer Consortium (DKTK) Partner Site Freiburg, Freiburg im Breisgau, GermanyDepartment of Nuclear Medicine, Medical Center—University of Freiburg, University of Freiburg, Faculty of Medicine, Freiburg im Breisgau, GermanyDepartment of Radiology, Medical Center—University of Freiburg, University of Freiburg, Faculty of Medicine, Freiburg im Breisgau, GermanyDepartment of Radiation Oncology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, GermanyGerman Cancer Consortium (DKTK) Partner Site Freiburg, Freiburg im Breisgau, Germany0Tumorbank Comprehensive Cancer Center Freiburg, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany1German Oncology Center, European University Cyprus, Limassol, Cyprus2Berta-Ottenstein-Programme, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, GermanyIntroductionAccurate detection and segmentation of the intraprostatic gross tumor volume (GTV) is pivotal for radiotherapy (RT) in primary prostate cancer (PCa) since it influences focal therapy target volumes and the patients’ cT stage. The study aimed to compare the performance of multiparametric resonance imaging (mpMRI) with [18F] PSMA-1007 positron emission tomography (PET) for intraprostatic GTV detection as well as delineation and to evaluate their respective influence on RT concepts.Materials and MethodsIn total, 93 patients from two German University Hospitals with [18F] PSMA-1007-PET/CT and MRI (Freiburg) or [18F] PSMA-1007-PET/MRI (Dresden) were retrospectively enrolled. Validated contouring techniques were applied for GTV-PET and -MRI segmentation. Absolute tumor volume and cT status were determined for each imaging method. The PCa distribution from histopathological reports based on biopsy cores and surgery specimen was used as reference in terms of laterality (unilateral vs. bilateral).ResultsIn the Freiburg cohort (n = 84), mpMRI and PET detected in median 2 (range: 1–5) and 3 (range: 1–8) GTVs, respectively (p < 0.01). The median GTV-MRI was significantly smaller than the GTV-PET, measuring 2.05 vs. 3.65 ml (p = 0.0005). PET had a statistically significant higher concordance in laterality with surgery specimen compared to mpMRI (p = 0.04) and biopsy (p < 0.01), respectively. PSMA PET led to more cT2c and cT3b stages, whereas cT3a stage was more pronounced in mpMRI. Based on the cT stage derived from mpMRI and PET information, 21 and 23 as well as 59 and 60 patients, respectively, were intermediate- and high-risk according to the National Comprehensive Cancer Network (NCCN) v1.2022 criteria. In the Dresden cohort (n = 9), similar results were observed.ConclusionIntraprostatic GTV segmentation based on [18F] PSMA-1007 PET results in more and larger GTVs compared to mpMRI. This influences focal RT target volumes and cT stage definition, but not the NCCN risk group.https://www.frontiersin.org/articles/10.3389/fonc.2022.880042/fullpositron-emission tomographymultiparametric MRIradiation therapyprostate cancerPSMA |
| spellingShingle | Ioana M. Marinescu Ioana M. Marinescu Simon K. B. Spohn Simon K. B. Spohn Selina Kiefer Peter Bronsert Lara Ceci Lara Ceci Julius Holzschuh Julius Holzschuh August Sigle Cordula A. Jilg Alexander Rühle Alexander Rühle Tanja Sprave Tanja Sprave Nils H. Nicolay Nils H. Nicolay Robert Winzer Robert Winzer Jana Rehm Jana Rehm Jörg Kotzerke Jörg Kotzerke Tobias Hölscher Tobias Hölscher Anca L. Grosu Anca L. Grosu Juri Ruf Matthias Benndorf Constantinos Zamboglou Constantinos Zamboglou Constantinos Zamboglou Constantinos Zamboglou Constantinos Zamboglou Intraindividual Comparison Between [18F] PSMA-1007 PET/CT and Multiparametric MRI for Radiotherapy Planning in Primary Prostate Cancer Patients Frontiers in Oncology positron-emission tomography multiparametric MRI radiation therapy prostate cancer PSMA |
| title | Intraindividual Comparison Between [18F] PSMA-1007 PET/CT and Multiparametric MRI for Radiotherapy Planning in Primary Prostate Cancer Patients |
| title_full | Intraindividual Comparison Between [18F] PSMA-1007 PET/CT and Multiparametric MRI for Radiotherapy Planning in Primary Prostate Cancer Patients |
| title_fullStr | Intraindividual Comparison Between [18F] PSMA-1007 PET/CT and Multiparametric MRI for Radiotherapy Planning in Primary Prostate Cancer Patients |
| title_full_unstemmed | Intraindividual Comparison Between [18F] PSMA-1007 PET/CT and Multiparametric MRI for Radiotherapy Planning in Primary Prostate Cancer Patients |
| title_short | Intraindividual Comparison Between [18F] PSMA-1007 PET/CT and Multiparametric MRI for Radiotherapy Planning in Primary Prostate Cancer Patients |
| title_sort | intraindividual comparison between 18f psma 1007 pet ct and multiparametric mri for radiotherapy planning in primary prostate cancer patients |
| topic | positron-emission tomography multiparametric MRI radiation therapy prostate cancer PSMA |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.880042/full |
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