Factors Associated with Increased Morbidity and Mortality of Obese and Overweight COVID-19 Patients
Overweight and obesity are defined as an unnecessary accumulation of fat, which poses a risk to health. It is a well-identified risk factor for increased mortality due to heightened rates of heart disease, certain cancers, musculoskeletal disorders, and bacterial, protozoan and viral infections. The...
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MDPI AG
2020-09-01
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| Online Access: | https://www.mdpi.com/2079-7737/9/9/280 |
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| author | Amany Magdy Beshbishy Helal F. Hetta Diaa E. Hussein Abdullah A. Saati Christian C. Uba Nallely Rivero-Perez Adrian Zaragoza-Bastida Muhammad Ajmal Shah Tapan Behl Gaber El-Saber Batiha |
| author_facet | Amany Magdy Beshbishy Helal F. Hetta Diaa E. Hussein Abdullah A. Saati Christian C. Uba Nallely Rivero-Perez Adrian Zaragoza-Bastida Muhammad Ajmal Shah Tapan Behl Gaber El-Saber Batiha |
| author_sort | Amany Magdy Beshbishy |
| collection | DOAJ |
| description | Overweight and obesity are defined as an unnecessary accumulation of fat, which poses a risk to health. It is a well-identified risk factor for increased mortality due to heightened rates of heart disease, certain cancers, musculoskeletal disorders, and bacterial, protozoan and viral infections. The increasing prevalence of obesity is of concern, as conventional pathogenesis may indeed be increased in obese hosts rather than healthy hosts, especially during this COVID-19 pandemic. COVID-19 is a new disease and we do not have the luxury of cumulative data. Obesity activates the development of gene induced hypoxia and adipogenesis in obese animals. Several factors can influence obesity, for example, stress can increase the body weight by allowing people to consume high amounts of food with a higher propensity to consume palatable food. Obesity is a risk factor for the development of immune-mediated and some inflammatory-mediated diseases, including atherosclerosis and psoriasis, leading to a dampened immune response to infectious agents, leading to weaker post-infection impacts. Moreover, the obese host creates a special microenvironment for disease pathogenesis, marked by persistent low-grade inflammation. Therefore, it is advisable to sustain healthy eating habits by increasing the consumption of various plant-based and low-fat foods to protect our bodies and decrease the risk of infectious diseases, especially COVID-19. |
| first_indexed | 2024-03-10T16:27:47Z |
| format | Article |
| id | doaj.art-a704cb72555c4ce49d56a8f0cc7b09c9 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T16:27:47Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-a704cb72555c4ce49d56a8f0cc7b09c92023-11-20T13:06:00ZengMDPI AGBiology2079-77372020-09-019928010.3390/biology9090280Factors Associated with Increased Morbidity and Mortality of Obese and Overweight COVID-19 PatientsAmany Magdy Beshbishy0Helal F. Hetta1Diaa E. Hussein2Abdullah A. Saati3Christian C. Uba4Nallely Rivero-Perez5Adrian Zaragoza-Bastida6Muhammad Ajmal Shah7Tapan Behl8Gaber El-Saber Batiha9National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada-cho, Obihiro, Hokkaido 080-8555, JapanDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut 71515, EgyptResearcher, Department of Food Hygiene, Agricultural Research Center (ARC), Animal Health Research Institute, Port of Alexandria 26514, EgyptDepartment of Community Medicine & Pilgrims Healthcare, Faculty of Medicine, Umm Al-Qura University Makkah, Mecca 24382, Saudi ArabiaDepartment of Microbiology, Paul University, Awka, Anambra State PMB 6074, NigeriaÁrea Académica de Medicina Veterinaria y Zootecnia, Instituto de Ciencias Agropecuaria, Universidad Autónoma del Estado de Hidalgo, Av. Universidad Km 1, Ex-Hda. de Aquetzalpa, Tulancingo 43600, Hgo, MexicoÁrea Académica de Medicina Veterinaria y Zootecnia, Instituto de Ciencias Agropecuaria, Universidad Autónoma del Estado de Hidalgo, Av. Universidad Km 1, Ex-Hda. de Aquetzalpa, Tulancingo 43600, Hgo, MexicoDepartment of Pharmacognosy, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad 38000, PakistanChitkara College of Pharmacy, Chitkara University, Punjab 140401, IndiaDepartment of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, EgyptOverweight and obesity are defined as an unnecessary accumulation of fat, which poses a risk to health. It is a well-identified risk factor for increased mortality due to heightened rates of heart disease, certain cancers, musculoskeletal disorders, and bacterial, protozoan and viral infections. The increasing prevalence of obesity is of concern, as conventional pathogenesis may indeed be increased in obese hosts rather than healthy hosts, especially during this COVID-19 pandemic. COVID-19 is a new disease and we do not have the luxury of cumulative data. Obesity activates the development of gene induced hypoxia and adipogenesis in obese animals. Several factors can influence obesity, for example, stress can increase the body weight by allowing people to consume high amounts of food with a higher propensity to consume palatable food. Obesity is a risk factor for the development of immune-mediated and some inflammatory-mediated diseases, including atherosclerosis and psoriasis, leading to a dampened immune response to infectious agents, leading to weaker post-infection impacts. Moreover, the obese host creates a special microenvironment for disease pathogenesis, marked by persistent low-grade inflammation. Therefore, it is advisable to sustain healthy eating habits by increasing the consumption of various plant-based and low-fat foods to protect our bodies and decrease the risk of infectious diseases, especially COVID-19.https://www.mdpi.com/2079-7737/9/9/280obesityCOVID-19coronavirusesinfluenzathrombosis |
| spellingShingle | Amany Magdy Beshbishy Helal F. Hetta Diaa E. Hussein Abdullah A. Saati Christian C. Uba Nallely Rivero-Perez Adrian Zaragoza-Bastida Muhammad Ajmal Shah Tapan Behl Gaber El-Saber Batiha Factors Associated with Increased Morbidity and Mortality of Obese and Overweight COVID-19 Patients Biology obesity COVID-19 coronaviruses influenza thrombosis |
| title | Factors Associated with Increased Morbidity and Mortality of Obese and Overweight COVID-19 Patients |
| title_full | Factors Associated with Increased Morbidity and Mortality of Obese and Overweight COVID-19 Patients |
| title_fullStr | Factors Associated with Increased Morbidity and Mortality of Obese and Overweight COVID-19 Patients |
| title_full_unstemmed | Factors Associated with Increased Morbidity and Mortality of Obese and Overweight COVID-19 Patients |
| title_short | Factors Associated with Increased Morbidity and Mortality of Obese and Overweight COVID-19 Patients |
| title_sort | factors associated with increased morbidity and mortality of obese and overweight covid 19 patients |
| topic | obesity COVID-19 coronaviruses influenza thrombosis |
| url | https://www.mdpi.com/2079-7737/9/9/280 |
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