The effectiveness of a fecal diverting device for prevention of septic complications in a dog model of ischemic bowel anastomosis
Summary: Objective: A type of bypass tube for a fecal diversion device (FDD) was created to protect colorectal anastomosis. We evaluated the effectiveness of the FDD in an animal study. Methods: The study was performed in an experimental animal laboratory of a tertiary referral center hospital. Thi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Asian Journal of Surgery |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958419300922 |
| _version_ | 1818291777059160064 |
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| author | Sung Il Kang So Hyun Kim Sang Hun Jung Jae Hwang Kim |
| author_facet | Sung Il Kang So Hyun Kim Sang Hun Jung Jae Hwang Kim |
| author_sort | Sung Il Kang |
| collection | DOAJ |
| description | Summary: Objective: A type of bypass tube for a fecal diversion device (FDD) was created to protect colorectal anastomosis. We evaluated the effectiveness of the FDD in an animal study. Methods: The study was performed in an experimental animal laboratory of a tertiary referral center hospital. Thirty mongrel dogs were randomized to the FDD or control group (n = 15, each). An ischemic anastomosis model was used to readily produce anastomotic leakage (AL) in both groups. The FDD was fixed intraluminally at 10 cm above the anastomotic site in the FDD group. No protective methods were used in the control group. The postoperative observation period was 3 weeks. Results: The 3 week-survival rates were higher in the FDD group compare with the control group (80%, 12/15 vs. 40%, 6/15; log-rank, P = 0.024). The incidence of AL causing generalized peritonitis was lower in the FDD group than in the control group (20.0%, 3/15 vs. 60.0%, 9/15; P = 0.025) despite the overall incidence of complications being similar in the both groups (53.3%, 8/15 vs. 66.7%, 10/15; P = 0.456). Colonic wall erosions in the FDD fixing area were seen in two subjects (13.3%) in the FDD group. However, the two subjects survived to the end of the experimental period. In the FDD group, five subjects (33.3%, 5/15) did not retain their FDD, and three among them died from generalized peritonitis. Conclusion: This study shows the effectiveness of the FDD at preventing septic complications in a dog model of ischemic bowel anastomosis. Keywords: Fecal diverting device, Anastomotic leakage, Ischemic bowel anastomosis |
| first_indexed | 2024-12-13T02:49:27Z |
| format | Article |
| id | doaj.art-a7056ad283014102968337fb6cfa92d7 |
| institution | Directory Open Access Journal |
| issn | 1015-9584 |
| language | English |
| last_indexed | 2024-12-13T02:49:27Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj.art-a7056ad283014102968337fb6cfa92d72022-12-22T00:02:06ZengElsevierAsian Journal of Surgery1015-95842020-01-01431251256The effectiveness of a fecal diverting device for prevention of septic complications in a dog model of ischemic bowel anastomosisSung Il Kang0So Hyun Kim1Sang Hun Jung2Jae Hwang Kim3Department of Surgery, College of Medicine, Yeungnam University, Daegu, South KoreaDepartment of Surgery, College of Medicine, Yeungnam University, Daegu, South KoreaDepartment of Surgery, Samil Hospital, Daegu, South KoreaDepartment of Surgery, College of Medicine, Yeungnam University, Daegu, South Korea; Corresponding author. Department of Surgery, Yeungnam University Medical Center, 170, Hyeonchung-ro, Nam-Gu, 42415, Daegu, South Korea. Fax: +82 53 624 1213.Summary: Objective: A type of bypass tube for a fecal diversion device (FDD) was created to protect colorectal anastomosis. We evaluated the effectiveness of the FDD in an animal study. Methods: The study was performed in an experimental animal laboratory of a tertiary referral center hospital. Thirty mongrel dogs were randomized to the FDD or control group (n = 15, each). An ischemic anastomosis model was used to readily produce anastomotic leakage (AL) in both groups. The FDD was fixed intraluminally at 10 cm above the anastomotic site in the FDD group. No protective methods were used in the control group. The postoperative observation period was 3 weeks. Results: The 3 week-survival rates were higher in the FDD group compare with the control group (80%, 12/15 vs. 40%, 6/15; log-rank, P = 0.024). The incidence of AL causing generalized peritonitis was lower in the FDD group than in the control group (20.0%, 3/15 vs. 60.0%, 9/15; P = 0.025) despite the overall incidence of complications being similar in the both groups (53.3%, 8/15 vs. 66.7%, 10/15; P = 0.456). Colonic wall erosions in the FDD fixing area were seen in two subjects (13.3%) in the FDD group. However, the two subjects survived to the end of the experimental period. In the FDD group, five subjects (33.3%, 5/15) did not retain their FDD, and three among them died from generalized peritonitis. Conclusion: This study shows the effectiveness of the FDD at preventing septic complications in a dog model of ischemic bowel anastomosis. Keywords: Fecal diverting device, Anastomotic leakage, Ischemic bowel anastomosishttp://www.sciencedirect.com/science/article/pii/S1015958419300922 |
| spellingShingle | Sung Il Kang So Hyun Kim Sang Hun Jung Jae Hwang Kim The effectiveness of a fecal diverting device for prevention of septic complications in a dog model of ischemic bowel anastomosis Asian Journal of Surgery |
| title | The effectiveness of a fecal diverting device for prevention of septic complications in a dog model of ischemic bowel anastomosis |
| title_full | The effectiveness of a fecal diverting device for prevention of septic complications in a dog model of ischemic bowel anastomosis |
| title_fullStr | The effectiveness of a fecal diverting device for prevention of septic complications in a dog model of ischemic bowel anastomosis |
| title_full_unstemmed | The effectiveness of a fecal diverting device for prevention of septic complications in a dog model of ischemic bowel anastomosis |
| title_short | The effectiveness of a fecal diverting device for prevention of septic complications in a dog model of ischemic bowel anastomosis |
| title_sort | effectiveness of a fecal diverting device for prevention of septic complications in a dog model of ischemic bowel anastomosis |
| url | http://www.sciencedirect.com/science/article/pii/S1015958419300922 |
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