Differential effects of innate immune variants of surfactant protein-A1 (SFTPA1) and SP-A2 (SFTPA2) in airway function after Klebsiella pneumoniae infection and sex differences

Differential effects of innate immune variants of surfactant protein-A1 (SFTPA1) and SP-A2 (SFTPA2) in airway function after Klebsiella pneumoniae infection and sex differences

Abstract Background Surfactant Protein-A (SP-A) is a major protein component of surfactant and plays a role in surfactant-related functions and innate immunity. Human SP-A consists of two functional genes, SFTPA1 and SFTPA2, encoding SP-A1 and SP-A2 proteins, respectively and each is identified with...

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Bibliographic Details
Main Authors: Nithyananda Thorenoor, Xuesheng Zhang, Todd M. Umstead, E. Scott Halstead, David S. Phelps, Joanna Floros
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Respiratory Research
Subjects:
Surfactant protein A1 and A2
Forced oscillation technique (FOT)
Infection
Airway hyperreactivity
Online Access:http://link.springer.com/article/10.1186/s12931-018-0723-1

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