Use of tetraethylammonium (TEA) and Tris loading for blocking TRPM7 channels in intact cells

Use of tetraethylammonium (TEA) and Tris loading for blocking TRPM7 channels in intact cells

Tetraethylammonium (TEA), a quaternary ammonium compound, is a well-known blocker of potassium channels belonging to various subfamilies, such as KV1-3, KCa1, 2 and prokaryotic KcsA. In many cases, TEA acts from the extracellular side by open pore blockade. TEA can also block transient receptor pote...

Full description

Bibliographic Details
Main Authors: Katherine G. Holderby, J. Ashot Kozak
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Pharmacology
Subjects:
lymphocyte
channel-kinase
HEK293
tetramethylammonium ion
tetraethylammonium ion
Tris hydrochloride
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1341799/full

Similar Items

Similar Items