Reduced Susceptibility to Neuraminidase Inhibitors in Influenza B Isolate, Canada
We identified an influenza B isolate harboring a Gly407Ser neuraminidase substitution in an immunocompromised patient in Canada before antiviral therapy. This mutation mediated reduced susceptibility to oseltamivir, zanamivir, and peramivir, most likely by preventing interaction with the catalytic A...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2019-04-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/25/4/18-1554_article |
| _version_ | 1811223792893034496 |
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| author | Yacine Abed Clément Fage Patrick Lagüe Julie Carbonneau Jesse Papenburg Donald C. Vinh Guy Boivin |
| author_facet | Yacine Abed Clément Fage Patrick Lagüe Julie Carbonneau Jesse Papenburg Donald C. Vinh Guy Boivin |
| author_sort | Yacine Abed |
| collection | DOAJ |
| description | We identified an influenza B isolate harboring a Gly407Ser neuraminidase substitution in an immunocompromised patient in Canada before antiviral therapy. This mutation mediated reduced susceptibility to oseltamivir, zanamivir, and peramivir, most likely by preventing interaction with the catalytic Arg374 residue. The potential emergence of such variants emphasizes the need for new antivirals. |
| first_indexed | 2024-04-12T08:38:51Z |
| format | Article |
| id | doaj.art-a708d162cf084442a4875e640e57d85a |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-04-12T08:38:51Z |
| publishDate | 2019-04-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-a708d162cf084442a4875e640e57d85a2022-12-22T03:39:57ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592019-04-0125483884010.3201/eid2504.181554Reduced Susceptibility to Neuraminidase Inhibitors in Influenza B Isolate, CanadaYacine AbedClément FagePatrick LagüeJulie CarbonneauJesse PapenburgDonald C. VinhGuy BoivinWe identified an influenza B isolate harboring a Gly407Ser neuraminidase substitution in an immunocompromised patient in Canada before antiviral therapy. This mutation mediated reduced susceptibility to oseltamivir, zanamivir, and peramivir, most likely by preventing interaction with the catalytic Arg374 residue. The potential emergence of such variants emphasizes the need for new antivirals.https://wwwnc.cdc.gov/eid/article/25/4/18-1554_articleinfluenza BresistanceneuraminidaseGly407Seroseltamivirzanamivir |
| spellingShingle | Yacine Abed Clément Fage Patrick Lagüe Julie Carbonneau Jesse Papenburg Donald C. Vinh Guy Boivin Reduced Susceptibility to Neuraminidase Inhibitors in Influenza B Isolate, Canada Emerging Infectious Diseases influenza B resistance neuraminidase Gly407Ser oseltamivir zanamivir |
| title | Reduced Susceptibility to Neuraminidase Inhibitors in Influenza B Isolate, Canada |
| title_full | Reduced Susceptibility to Neuraminidase Inhibitors in Influenza B Isolate, Canada |
| title_fullStr | Reduced Susceptibility to Neuraminidase Inhibitors in Influenza B Isolate, Canada |
| title_full_unstemmed | Reduced Susceptibility to Neuraminidase Inhibitors in Influenza B Isolate, Canada |
| title_short | Reduced Susceptibility to Neuraminidase Inhibitors in Influenza B Isolate, Canada |
| title_sort | reduced susceptibility to neuraminidase inhibitors in influenza b isolate canada |
| topic | influenza B resistance neuraminidase Gly407Ser oseltamivir zanamivir |
| url | https://wwwnc.cdc.gov/eid/article/25/4/18-1554_article |
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