Efficacy of different doses of corticosteroids in treating severe COVID-19 pneumonia
Abstract Background To investigate the efficacy of different doses of corticosteroids in treating severe coronavirus disease 2019 (COVID-19) pneumonia. Methods Between May 01, 2023, and June 20, 2023, 48 patients with severe COVID-19 pneumonia were treated at the Department of Respiratory and Critic...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Virology Journal |
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| Online Access: | https://doi.org/10.1186/s12985-024-02345-7 |
| _version_ | 1827301344463028224 |
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| author | Ge zhang Lin Su Wenwen Wu Qing Qiao Shuncui Gao Yan Zhang Yanmei Zhang |
| author_facet | Ge zhang Lin Su Wenwen Wu Qing Qiao Shuncui Gao Yan Zhang Yanmei Zhang |
| author_sort | Ge zhang |
| collection | DOAJ |
| description | Abstract Background To investigate the efficacy of different doses of corticosteroids in treating severe coronavirus disease 2019 (COVID-19) pneumonia. Methods Between May 01, 2023, and June 20, 2023, 48 patients with severe COVID-19 pneumonia were treated at the Department of Respiratory and Critical Care Medicine of Jinan Fourth People's Hospital. The observation group (21 patients) received standard care and high-dose corticosteroids, (high-dose group). The control group (27 patients) received standard care and low-dose corticosteroids (low-dose group). We collected baseline data and recorded inflammatory marker levels after 3 days of treatment, body temperature recovery time, length of stay, and 28-day all-cause mortality. The results of outpatient follow-up were recorded after 1 month. Results There were no significant differences in 28-day mortality and length of stay. The number of days it took for body temperature to return to normal in the high-dose group was less than in the low-dose group. The high-dose group had significantly more reduced inflammatory factors (C-reactive protein (CRP), interleukin-6 (IL-6). A total of 20 discharged patients were given 8–16 mg of methylprednisolone, depending on chest computed tomography (CT) and clinical symptoms after 1 month; in all discharged patients using oral corticosteroids, CT features improved. Conclusion High-dose corticosteroids had a significantly positive effect on the reduction of inflammatory factors and shortening body temperature recovery time. In the treatment of severe COVID-19 pneumonia, early administration of high-dose, short-course corticosteroids should be implemented. |
| first_indexed | 2024-04-24T16:22:37Z |
| format | Article |
| id | doaj.art-a708f15f508143de853dc86de19ba366 |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-04-24T16:22:37Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-a708f15f508143de853dc86de19ba3662024-03-31T11:10:32ZengBMCVirology Journal1743-422X2024-03-012111810.1186/s12985-024-02345-7Efficacy of different doses of corticosteroids in treating severe COVID-19 pneumoniaGe zhang0Lin Su1Wenwen Wu2Qing Qiao3Shuncui Gao4Yan Zhang5Yanmei Zhang6Department of Respiratory and Critical Care Medicine, The Third Affiliated Hospital of Shandong First Medical University, Jinan Fourth People’s HospitalDepartment of Respiratory and Critical Care Medicine, The Third Affiliated Hospital of Shandong First Medical University, Jinan Fourth People’s HospitalDepartment of Respiratory and Critical Care Medicine, The Third Affiliated Hospital of Shandong First Medical University, Jinan Fourth People’s HospitalDepartment of Respiratory and Critical Care Medicine, The Third Affiliated Hospital of Shandong First Medical University, Jinan Fourth People’s HospitalDepartment of Respiratory and Critical Care Medicine, The Third Affiliated Hospital of Shandong First Medical University, Jinan Fourth People’s HospitalDepartment of Respiratory and Critical Care Medicine, The Third Affiliated Hospital of Shandong First Medical University, Jinan Fourth People’s HospitalDepartment of Respiratory and Critical Care Medicine, The Third Affiliated Hospital of Shandong First Medical University, Jinan Fourth People’s HospitalAbstract Background To investigate the efficacy of different doses of corticosteroids in treating severe coronavirus disease 2019 (COVID-19) pneumonia. Methods Between May 01, 2023, and June 20, 2023, 48 patients with severe COVID-19 pneumonia were treated at the Department of Respiratory and Critical Care Medicine of Jinan Fourth People's Hospital. The observation group (21 patients) received standard care and high-dose corticosteroids, (high-dose group). The control group (27 patients) received standard care and low-dose corticosteroids (low-dose group). We collected baseline data and recorded inflammatory marker levels after 3 days of treatment, body temperature recovery time, length of stay, and 28-day all-cause mortality. The results of outpatient follow-up were recorded after 1 month. Results There were no significant differences in 28-day mortality and length of stay. The number of days it took for body temperature to return to normal in the high-dose group was less than in the low-dose group. The high-dose group had significantly more reduced inflammatory factors (C-reactive protein (CRP), interleukin-6 (IL-6). A total of 20 discharged patients were given 8–16 mg of methylprednisolone, depending on chest computed tomography (CT) and clinical symptoms after 1 month; in all discharged patients using oral corticosteroids, CT features improved. Conclusion High-dose corticosteroids had a significantly positive effect on the reduction of inflammatory factors and shortening body temperature recovery time. In the treatment of severe COVID-19 pneumonia, early administration of high-dose, short-course corticosteroids should be implemented.https://doi.org/10.1186/s12985-024-02345-7Severe COVID-19 pneumoniaCorticosteroidInflammatory factorsMortalityChest CT features |
| spellingShingle | Ge zhang Lin Su Wenwen Wu Qing Qiao Shuncui Gao Yan Zhang Yanmei Zhang Efficacy of different doses of corticosteroids in treating severe COVID-19 pneumonia Virology Journal Severe COVID-19 pneumonia Corticosteroid Inflammatory factors Mortality Chest CT features |
| title | Efficacy of different doses of corticosteroids in treating severe COVID-19 pneumonia |
| title_full | Efficacy of different doses of corticosteroids in treating severe COVID-19 pneumonia |
| title_fullStr | Efficacy of different doses of corticosteroids in treating severe COVID-19 pneumonia |
| title_full_unstemmed | Efficacy of different doses of corticosteroids in treating severe COVID-19 pneumonia |
| title_short | Efficacy of different doses of corticosteroids in treating severe COVID-19 pneumonia |
| title_sort | efficacy of different doses of corticosteroids in treating severe covid 19 pneumonia |
| topic | Severe COVID-19 pneumonia Corticosteroid Inflammatory factors Mortality Chest CT features |
| url | https://doi.org/10.1186/s12985-024-02345-7 |
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